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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 3 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Strain-independen temperature measurement using a type-land type - ⅡA optical fiber Bragg grating combination显示文摘 | S Pal T Sun K T V Grattan S A Wade S F Collins G W Baxter B Dussardier and G Monnom | 2004 | Rev Sci Instrum2004，75，： | 1 |
| 6 | Detection of chloramphenicol and chloramphenicol glucuronide residues in poultry muscle,honey,prawn and milk using a surface plasmon resonance biosensor and Qflex kit chloramphenicol显示文摘 | Ferguson J Baxter A Young P | 2005 | Anal Chim Acta2005，529，： | 1 |
| 7 | Social and Analytic Scaffolding in Middle School Mathematics: Managing the Dilemma of Telling 显示文摘 | Baxter J A Williams S | 2010 | Journal of Mathematics Teacher Education2010，，13： | 1 |
| 8 | Wettability of porous surfaces 显示文摘 | Cassie A B D Baxter S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 9 | Wettability of porous surface 显示文摘 | CASSIE A B D BAXTER S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 10 | A geostatistical analysis of the spatial variation of soil mineral nitrogen and potentially available nitrogen within an arable field显示文摘 | Baxter S J Oliver M A Gaunt J | 2003 | Precision Agriculture2003，，4： | 1 |
| 11 | Frequency selectivity, multistability, and oscillations emerge from models ofgenetic regulatory systems显示文摘 | SMOLEN P BAXTER D A BYRNE J H | 1998 | Amer J Phys1998，274，： | 1 |
| 12 | Should global burden of disease estimates include depression as a risk factor for coronary heart disease? 显示文摘 | CHARLSON F J STAPELBERG N J BAXTER A J | 2011 | BMC Meal2011，9，： | 1 |
| 13 | Wettability of porous surfaces显示文摘 | CASSIE A B D BAXTER S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 14 | Biosensor assay of sulfadiazine and sulfamethazine residues in pork 显示文摘 | Bjurling P Baxter G A Caselunghe M | 2000 | Analyst2000，125，10： | 1 |
| 15 | Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments显示文摘 | BAXTER B T DAVIS V A Minion D J | 1994 | J Vasc Surg1994，19，： | 1 |
| 16 | Extravasation of radiographic contrast is an independent predictor of death in primary intracerebral hemorrhage显示文摘 | Becker K J Baxter A B Bybee H M | 1999 | Stroke1999，30，10： | 1 |
| 17 | Errors and violations on the roads显示文摘 | Reason J T Manstead A S R Stradling S Baxter J & Campbell K | 1990 | Ergonomics1990，33，1011： | 1 |
| 18 | Wettability of porous surfaces显示文摘 | Cassie A B D Baxter S | | 0，，05： | 1 |
| 19 | Wettability of porous surfaces显示文摘 | Cassie A B D Baxter S | | 0，，： | 1 |
| 20 | Surgical parathyroidectomy versus cinacalcet therapy: in the management of secondary hy- perparathyroidism显示文摘 | ghaai A Baxter P | 2011 | Otolaryngol Head Neck Surg2011，0，： | 1 |
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