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| 1 | Osteoporosis in primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC) is an autoimmune cholestatic liver disease with multiple debilitating complications. Osteoporosis is a common complication of PBC resulting in frequent fractures and leading to significant morbidity in this population, yet evidence for effective therapy is lacking. We sought to summarize our current understanding of the pathophysiology of osteoporosis in PBC, as well as current and emerging therapies in order to guide future research directions. A complete search with a comprehensive literature review was performed with studies from Pub Med, EMBASE, Web of Science, Cochrane database, and the Countway Library. Osteoporosis in PBC is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Despite this fundamental difference, current treatment recommendations are based primarily on experience with postmenopausal osteoporosis. Trials specific to PBC-related osteoporosis are small and have not consistently demonstrated a benefit in this population. As it stands, prevention of osteoporosis in PBC relies on the mitigation of risk factors such as smoking and alcohol use, as well as encouraging a healthy diet and weight-bearing exercise. The primary medical intervention for the treatment of osteoporosis in PBC remains bisphosphonates though a benefit in terms of fracture reduction has never been shown. This review outlines what is known regarding the pathogenesis of bone disease in PBC and summarizes current and emerging therapies. | Christopher J Danford Hirsh D Trivedi Konstantinos Papamichael Elliot B Tapper Alan Bonder | 2018 | World Journal of Gastroenterology2018，24，31： | 13 |
| 2 | Land surface temperature andcharacteristics for a raingarden insoil moisture distributionFitzroy Gardens, Melbourne显示文摘To better understand the cooling effect of araingarden in Fitzroy Gardens, Melbourne, as well as itsbenefits for an urban microclimate, two rounds of 36-hmicroclimate monitoring at the raingarden were conducted.Land surface temperature and soil moisture were analyzedaccording to monitoring data. The results show a clearraingarden cooling effect in summer. The largest difference ofland surface temperatures inside and outside the raingarden Canreach 23.6 ℃, and the diurnal variation in temperature insidethe raingarden was much less than that outside the raingarden.The soil moisture increased rapidly after irrigation, with theincrease in the volumetric water content (VWC) of 2% to3.6%. The soil moistures of adjacent irrigated garden bedsand grass were higher than those inside the raingarden.Monitoring soil moisture helps guide raingarden irrigation. | Miao Shujiang Nigel Tapper | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 3 |
| 3 | Variation within isolates of Acremonium endophytes from perennial ryegrass显示文摘 | Christensen M J Latch G C M Tapper B A | 1991 | Mycology Research1991，95，： | 1 |
| 4 | Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study 显示文摘 | Ciomei CD Tapper H Bjartell A | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 5 | Optimization of a precision-cut trout liver slice assay as a screen for vitellogenin induction:comparison of slice in incubation techniques显示文摘 | Schmieder P Tapper M Linnum A | 2000 | Aquatic Toxicol2000，49，： | 1 |
| 6 | Haplotypic analysis of the MMP-9 gene in relation to coronary artery disease显示文摘 | Morgan AR Zhang B Tapper W | | 0，，05： | 1 |
| 7 | Characteristics influencing the variability of urban CO2 fluxes in melbourne,Australia显示文摘 | COUTTS A M BERINGER J TAPPER N J | | 0，，01： | 1 |
| 8 | The need for clarity in occult HBV infection显示文摘 | Tapper EB Lau DT | 2011 | J Viral Hepat2011，18，10： | 1 |
| 9 | Positive matrix factorization-a nonnegative factor model with optimal utilization of error-estimates of data values 显示文摘 | Paatero P Tapper U | 1994 | Environmetrics1994，5，： | 1 |
| 10 | The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Soxl0 显示文摘 | Mou Z Tapper AR Gardner PD | 2009 | J Biol Chem2009，284，13： | 1 |
| 11 | Positive Matrix Factorization: A Nonnegative Factor Model with Optimal Utilization of Error Estimates of Data Values显示文摘 | Paatero P Tapper U | 1994 | Environmetries1994，5，2： | 1 |
| 12 | A comparison of air particulate matter and associated polycyelic aromatic hydrocarbons in some tropical and temperate urban environments显示文摘 | Panther B C Hooper M A Tapper N J | 1999 | Atmos Environ1999，33，： | 1 |
| 13 | Analysis of different modes of factor analysis as least squares fit problem 显示文摘 | Paatero P Tapper U | 1993 | Chemometrics and Intelligent Laboratory Systems1993，18，2： | 1 |
| 14 | Surface modification of atmos- pheric plasma activated BOPP by immobilizing chitosan显示文摘 | Vartiainen J Tapper U | 2005 | Polymer Bulletin2005，54，45： | 1 |
| 15 | Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer显示文摘 | Improgo M R Tapper A R Gardner P D | | 0，，8： | 1 |
| 16 | Climate ex- tremes: progress and future directions显示文摘 | Alexander L V Tapper N Zhang X eta | 2009 | International Journal of Climatology2009，29，3： | 1 |
| 17 | Importance of MEK in neutrophil microbicidal responsiveness显示文摘 | Downey GP Butler JR Tapper H | 1998 | J Immunol1998，160，1： | 1 |
| 18 | KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes显示文摘 | Andelfinger G Tapper AR Welch RC | 2002 | Am J Hum Genet2002，71，3： | 1 |
| 19 | Estimation of PAHsdry deposition and BaP toxic equivalency factors (TE-Fs) study at urban, industry park and rural samplingsites in central Taiwan, Taichung 显示文摘 | Fang G C Chang K F Tapper N J | 2004 | Chemosphere2004，55，6： | 1 |
| 20 | Study of the interaction of sulphate-reducing bacteria exopolymers with iron using X-ray photoelectron spectroscopy and time-of-flight secondary ionisation mass spectrometry显示文摘 | I.B Beech V Zinkevich R Tapper R Gubner R Avci | 1999 | Journal of Microbiological Methods1999，，1： | 1 |
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