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| 1 | MICROVASCULAR DECOMPRESSION FOR HEMIFACIAL SPASM - TECHNICAL NOTES AND COMPLICATION PREVENTION : EXPERIENCE OF 338 CASES显示文摘Objective:To summarize our clinical experience of microvascular decompression(MVD) for medically intractable spasm(HFS) patients with emphasis on microsurgical manipulation and to improve cure rate and avoid surgical complications.Methods:Three hundred and thirty-eight patients with HFS underwent MVD under general anesthesia:With the help of “zero retraction”technique,prosthesis can be properly inserted between offending vessel loop and affected facial nerve REZ in a “rolling ball” fashion under operative microscope.Results :Surgical intervention achieved high relief rate of 91.4% and no major complications,with low recurrence rate of only 3.2% after averaging more than two year's follow-up(M=32 months).Conclusion :It is possible to approach to the facial nerve REZ with“zero retraction”,which is fundamentally important to clear from cranial nerve and cerebellar injury.Skilled microsurgical technique along with correct recognition and mobilization of offending vessels are a must to assure MVD a highly efficacious and low risk treatment of choice for HFS patients. | 赵卫国 濮春华 沈建康 卞留贯 成侃 孙青芳 胡锦清 朱军 | 2003 | Journal of Shanghai Second Medical University(Foreign Language Edition)2003，15，1： | 12 |
| 2 | EFFECTS OF PHYCOCYANIN ON EXPRESSION OF CytC mRNA AND CASPASE-3 mRNA AFTER FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS显示文摘Objective To study the effects of phycocyanin on the expression of Cytochrome C (CytC)genes and Caspase-3 genes after focal cerebral ischemia/reperfusion in rats. Methods A rat middle cerebral ar-tery occlusion (MCAO)/reperfusion model was produced using the intraluminal filament method. The rats were di-vided into three groups: sham operation group, model control group and phycocyanin group. After MCAO, the neu-robehavioral testing of all rats was made. The infarction area was evaluated with the method of 2,3,7-triphenyltet-razolium chloride (TTC) staining. The expression of CytC mRNA and Caspase-3 mRNA were determined by in situhybridization. Results In the sham operation group and the model control group, there was only a few CytC-positive cells were seen in the normal cerebral tissue. In the model control group, the upregulation of CytC mRNAbegan 6h after ischemia, reached a maximum at 12h (cortex) -24h (striatum) , then subsided gradually, but stillin high level. In the phycocyanin group, CytC-positive cells were also mainly in cortex and striatum, but the numberof the cells was significantly lower than the number of the model control group. The time-phase pattern of CytCmRNA in the phycocyanin group was similar to the pattern of the model control group. In the sham operation groupand the model control group, there was only a few Caspase-3-positive cells were seen in the normal cerebral tissue.In the model control group, the upregulation of Caspase-3 mRNA began 6h after ischemia, reached a maximum at24h and subsided at 48h, but still in high level. In the phycocyanin group, Caspase-3-positive cells were also mainlyin the penumbral area, but the number of the cells were significantly lower than the number of the model controlgroup. The time-phase pattern of Caspase-3 mRNA in the phycocyanin group was similar to the pattern of the modelcontrol group. Conclusion The over-expression of CytC mRNA and Caspase-3 mRNA might play a key role inischemic cerebral injury after MCAO. Phycocyanin could inhibit the over-expression of CytC mRNA and Caspase-3mRNA in the cerebral cortex, and might play an important role in the protection of ischemic neurons. | 陈红兵 孙圣刚 童萼塘 郭云良 金丽英 | 2005 | Journal of Shanghai Second Medical University(Foreign Language Edition)2005，17，1： | 4 |
| 3 | BIOAVAILABILITY AND PHARMACOKINETICS OF ANASTROZOLE IN HEALTHY MALE VOLUNTEERS显示文摘Objective To evaluate bioavailability and pharmacokinetics of domestic and imported anastrozole tablets.Methods Twenty Chinese healthy male volunteers were enrolled in a randomized crossover study with a single oral dose of 2mg of the two formulations respectively. The anastrozole in plasma was measured by gas chromatography with electron-capture detection. The linear range was 1. 325-106ng /ml plasma. The extraction recovery rates for plasma concentration of 5.3, 21.2 and 53. 0ng/ml were 76.8%,87.0% and 78.7%, respectively. Inter-day and intra-day precisions of the method were < 9%. Area underconcentration-time curve ( AUC0-1), maximum plasma concentration (Cmax) and reach peak time (Tmax) were evaluated by variance analysis and two one-side t-test . Results A two-compartment model was adopted in anastrozole plasma concentration-time data analysis. The main pharmacokinetic parameters of domestic and imported anastrozloe tablets such as Cmax, Tmax, AUC0 - 1 and T1/2β were (36.5± 6.9) ng /ml and (35.6±9.4)ng/ml, (1.56 ±0.41)h and(1.53 ±0.49)h, (1403.6± 321.2)ng·h/ml and (1371.6±329.4)ng.h/ml, ( 42.57 ±10.15) h and ( 43.41 ±8.59 ) h, respectively, and there were no significant differences be-tween the two formulations. Conelusion Domestic and imported anastrozole tablets were of bioequivalence.The relative bioavailability of the domestic tablet was ( 102.7± 5.6 )%. | 安富荣 崔岚 刘晓琰 王平全 祝德秋 曹惠明 | 2002 | Journal of Shanghai Second Medical University(Foreign Language Edition)2002，14，2： | 2 |
| 4 | INHIBITION OF HUMAN EXPERIMENTAL GASTRIC CARCINOMA METASTASIS IN VIVO BY P-SELECTIN MONOCLONAL ANTIBODY显示文摘Objective To study the role of cell adhesion molecule P-selectin monoclonal antibody (MAb) in tumor metastasis of an orthotopic metasta tic model. Methods SUD mice were implanted orthotopically SGC-7901 human gastric cancer tissue. 3d later, animals received i. v. injections of PBS or P-selectin MAb (100μg/injection) twice weekly for 3 weeks. 42d after operation, all animals were sacrificed. Tissues from all organs were obtained for histopathological evaluation. Results 10 of the animals ( n = 11) treat-ed with PBS were found to develop metastatic tumors in the regional lymph nodes, liver, and lung. In contrast, 2 of the animals ( n = 9) treated with P-selectin MAb developed metastatic tumors in the organs examined. The expression of P-selectin mRNA in gastric cancer tissue of SCID mice with tumor metastasis was higher than that without such metastasis. Conclusion P-selectin expression is associated with tumor metastasis, and the metastasis may be inhibited by the MAb. | 陈金联 陈维雄 朱金水 陈尼维 姚明 周同 | 2001 | Journal of Shanghai Second Medical University(Foreign Language Edition)2001，13，1： | 2 |
| 5 | EFFECT OF TITANIUM-ALLOY PARTICLES ON EXPRESSION OF MEDIATING-RELATED GENES IN HUMAN OSTEOBLASTS显示文摘Objective To study mRNA expression of the mediating-related genes in osteoblasts after exposure to Titanium-alloy particles and cytochalasin-D. Methods Human osteoblasts were isolated from trabecular fragments and exposed to 0.01% (v/v) titanium-alloy particles for 8h. Pretreatment of osteoblasts with cytochalasin-D( 5μmol/L ) to prevent phagocytosis prior to the addition of Titanium-alloy particles, mRNA expression of RANKL, OPG, and IL-6 was semi-quantified by RT-PCR. Results Expressions of RANKL, OPG, and IL-6 mRNA at respective levels were found in osteoblasts under normal condition, which did not show significant changes in the samples treated with cytochalasin-D but without particles. Exposure of osteoblasts to particles after being treated with or without cytochalasin-D altered mRNA expression of these genes, however, an increase in the ratio of RANKL/OPG mRNA was only found in samples without cytochalasin-D treatment. Conclusion Changes of expression of RANKL, OPG, and IL-6 mRNA in osteoblasts after exposure to titanium-alloy particles were independent of phagocytosis, whereas phagocytosis has a direct effect on their ability to stimulate osteoclast differentiation and function. | 杨旭 杨庆铭 邓廉夫 许福平 张玥 | 2004 | Journal of Shanghai Second Medical University(Foreign Language Edition)2004，16，1： | 2 |
| 6 | STUDY ON THE RELATIONSHIP OF ARSENIC TRIOXIDE-INDUCED BIOLOGICAL EFFECTS AND DEGRADATION OF PML PROTEINS显示文摘Objective: To understand whether arsenic trioxide (As2O3 )-induced biological effects are associated with degradation of PML proteins. Methods Acute promyelocytic leukemia (APL) cell line NB4, acute T-lymphocytic leukemia cell line Jurkat, acute myeloid leukemia cell line U937, and chronic myelocytic leukemia blast crisis cell line K562 were used as in vitro models In different cell lines, the As2O3-induced biological effects were determined by cell growth, cell viability, cell morphology, and flow cytometry assay on sub G1 cell content. The alteration of PML proteins was analyzed by immunofluorescence Results in terms of growth inhibition and apoptosis induction, 1. 0μmol/L As2O3 had different effects on different cell lines. However, degradation of PML proteins occurred in all the cell lines with As2O3 treatment. Conclusion As2O3-indued biological effects may be independent of PML protein-degradation. | 陈竺 王振义 蔡循 陈国强 余韵 贾培敏 | 2001 | Journal of Shanghai Second Medical University(Foreign Language Edition)2001，13，2： | 2 |
| 7 | APOPTOSIS IN GASTRIC CANCER INDUCED BY TRICHOSANTHIN AND RELATIONSHIP OF THIS APOPTOSIS WITH EXPRESSION OF C-MYC显示文摘Objective To investigate the apoptosis in gastric cancer induced by trichosanthin (TCS) and the relationship between this apoptosis and expression of c-myc. Methods In in vitro experiment, morphologic test and TUNEL staining method were used to detect quantitatively and qualitatively the apoptosis status of gastric adenocarcinoma cell line SGC-7901 before and after the treatment of 0.1μg/ml TCS. Immunohistochemical staining method and Northern Blot hybridization were used to detect the expression status of apoptosis-related genes c-myc before and after TCS treatment. Results Some typical apoptotic morphologic changes appeared after 36h treated by TCS. The apoptotic indexes increased significantly in the TCS treated group than those of the untreated group after 36h,42h and 48h (P<0.01). After 24h treated by TCS, an increased expression of c-myc protein product occurred, the staining density was increased from + or ++ to +++ (P< 0.01), and the expression of c-myc RNA increased significantly (P<0.05). Conclusion TCS is able to induce the apoptosis in gastric cancer. This apoptosis may be mediated by up-expression of apoptosis-regulated gene c-myc. | 胡梅洁 张曙 吴裕忻 吴云林 乔敏敏 章永平 符华 | 2002 | Journal of Shanghai Second Medical University(Foreign Language Edition)2002，14，1： | 2 |
| 8 | RELATIONSHIP BETWEEN SOMATOSTATIN RECEPTORS AND ACTIVATION OF HEPATIC STELLATE CELL显示文摘To investigate the relationship between expression of somatostatin receptors (SSTRs) and activation of rat hepatic stellate cell (HSC). Methods HSCs were isolated from rats by in situ perfusion and single-step density gradient centrifugation, and then SSTR1-5 mRNA levels in the differentiated frst passage HSCs were detected by means of reverse transcription polymerase chain reaction. On the other hand, hepatic fibrosis was induced in adult male Sprague-Dawley rats by carbon tetrachloride intoxication, and the expression of SSTR1-5 in normal as well as fibrotic liver was measured by immunohistochemical staining. Results SSTR mRNA and SSTR couM not be found in freshly isolated rat HSCs and normal rat liver. But SSTR1-3 mRNA appeared as HSCs became wholly activated, and SSTR1-3 could also be identified on the membrane of activated HSCs in the perisinusoid space, fibrous septa, etc. Conclusion The expression of SSTRt -3 in the rat HSC is closely related to its activation. This may reflect one of the main negative regulation mechanisms in the course of HSC activation. | 潘勤 李定国 陆汉明 尤汉宁 徐芹芳 陆良勇 | 2004 | Journal of Shanghai Second Medical University(Foreign Language Edition)2004，16，2： | 2 |
| 9 | EXPERIMENT AND RESEARCH ON DEVELOPMENT AND CHARACTERIZATIONS OF ANODIC ALUMINA MEMBR-ANE FOR USE IN HEMODIALYSIS显示文摘Objective The correlation between various formative conditions and the pore characterizationsof the anodic alumina membrane is investigated to seek the optimal conditions for the formation of anodic aluminamembrane. Methods High purity aluminum foils are used as the starting materials. The anodization is conduc-ted in three types of electrolytes, 3% sulfuric acid, 5% sulfuric acid and 2. 7% oxalic acid, respectively, with dif-ferent voltages at for 48h. The characterizations of the pore size, the effective porosity and the pore porosity areobserved and determined by scanning electron microscopy. The hydraulic conductances of the membranes are meas-ured to confirm that the pores are open and evaluate the permselectivity of the membranes. Results The experi-mental result shows that the ordered pore arrays are obtained for oxidation under our experimental conditions. Withthe increasing of the voltage, the pore size and pore porosity increased significantly (P <0.05) , while the effectiveporosity decreased significantly (P <0.05) with the same electrolyte. The pore size formed in 3% sulfuric acid or5% sulfuric acid is much smaller than in 2. 7% oxalic acid as an electrolyte. The hydraulic conductance of anodicalumina membrane that formed under our experimental condition is higher than those of the membranes are availablecurrently used in clinical. Conclusion The results suggest that the optimal conditions for the formation of anodicalumina membrane that used in hemodialysis are in 3% or 5% sulfuric acid with 12. 5V to 17. 5V at for 48h. | 张伟明 钱家麒 黄忠平 余建平 高大勇 | 2005 | Journal of Shanghai Second Medical University(Foreign Language Edition)2005，17，1： | 2 |
| 10 | Locus of Learning and Affective Strategy Use: Two Factors Affecting Success in Self-Instructed Language Learning 显示文摘 | Bown J | 2006 | Foreign Language Journal2006，，4： | 1 |
| 11 | Reflections on theoretical pragmatics显示文摘 | Huang Yah (2001a) | 2001 | Waiguoyu (Journal of Foreign Languages)2001，131，： | 1 |
| 12 | The effect of blog peer review and teacher feedback on the revisions of EFL writers显示文摘 | Wu W S | 2006 | Journal of Education and Foreign Languages and Literature2006，，3： | 1 |
| 13 | AN EPIDEMIOLOGICAL SURVEY OF CHOLELITHIASIS IN SHANGHAI显示文摘Objective:To obtain a general overview of gallstone disease in Shanghai.Methods 3415 citizens aged>20 in the community of Shanghai were randomly selected to undergo a clinical epidemiological study and an ultrasound examination to screen for cholielithiasis.Results:Overall prevalence rate of gallstones was 6.5% (8.6% in women and 5.1% in men).Among the 3415 persons investigated,65 had already undergone cholecystectomy.The perecentage of aymptomatic gallistone was 70.5%.Prevalence of gallstone diseases(gallstones plus cholecystectomy) increased with age significantly.Conclusion:Compared to the research in Shang hai ten years ago,especially for the persons older than 50 years.the gallstone disease has become more frequent.The proportion of asymptomatic gallstones and the awareness is increasing. | 叶忻 韩天权 王保钢 肖志坤 | 2003 | Journal of Shanghai Second Medical University(Foreign Language Edition)2003，15，1： | 1 |
| 14 | Foreign language learning anxiety in Japanese EFL university classes:Causes, coping and lo- cus of control 显示文摘 | Williams K E Andrade M R | 2008 | Electronic Journal of Foreign Language Teaching2008，5，2： | 1 |
| 15 | STUDY ON OBESITY RELATED FACTORS: FFA, LEPTIN AND ADIPONECTIN IN SUBJECTS WITH VARYING GLUCOSE TOLERANCE显示文摘Objective To study the fasting serum levels of obesity related factors: FFA, leptin and adi-ponectin in subjects with varying glucose tolerance and their relationship with BMI, insulin sensitivity index and isletbeta-cell function. Methods Serum levels of FFA, leptin and adiponectin in 24 normal, 32 simple obese, 34IGT and 36 T2DM subjects were measured by ACS-ACOD assay or RIA. Results The serum levels of leptin andFFA in three groups:simple obese, IGT and DM were much higher than those in normal control (P <0. 001). Incontrast, serum level of adiponectin of simple obese, IGT and DM groups were significant lower than that of normalcontrol, among them DM subjects had the lowest level (P <0. 001). Correlation analysis showed that FFA was pos-itively correlated to BMI, WHR, FBG, fasting insulin level and negatively correlated to SI; adiponectin was negativelycorrelated to BMI, WHR, FBG, PBG, but positively correlated to SI and AIRg; and leptin was positively correlated toBMI, fasting insulin and AIRg when negatively correlated to FBG and SI. None of them was correlated to age.Conclusion Subjects with insulin resistance have high serum FFA and leptin levels but low serum adiponectin level.With the glucose tolerance deterioration, serum FFA level increases much higher while the adiponectin deceases muchlower. Unlike insulin, none of these obesity related factors can be used as the simple indicating or determining factorof SI, though each of them, to different extent, takes part in the development of insulin resistance. | 顾卫琼 洪洁 张翼飞 宁光 陈名道 唐金凤 | 2005 | Journal of Shanghai Second Medical University(Foreign Language Edition)2005，17，1： | 1 |
| 16 | Study of politeness in Chinese and English cultures显示文摘 | He Zhaoxiong (1995) | 1995 | Journal of Foreign Languages1995，5，： | 1 |
| 17 | Locus of learning and affective strategy use : two factors affecting success in self-instructed language learning显示文摘 | Bown J | 2006 | Foreign Language Journal2006，39，4： | 1 |
| 18 | Cognitive Poetics and Speaking the Unspeakable 显示文摘 | Tsur R | 2008 | Journal of Foreign Language2008，，04： | 1 |
| 19 | EFFECT OF FK224 ON THE BRONCHOCONSTRIC TIONINDUCED BY ISOCAPNIC HYPERPNEA IN GUINEA PIGS显示文摘Objective To evaluate effect of Neurokinin receptor antagonist on the prevention from hyper-pnea-induced bronchoconstriction using a dual Neurokinin receptor antagonist FK224. Methods 12 pathogen-free Hartley guinea pigs were divided into two groups randomly-. Dimethyl sulfoxide (DMSO) control group (n =6)and FK224 group (n =6). Guinea pigs were anesthetized with pentobarbital sodium. A cervical tracheostomy wasperformed and a polyethylene tube was inserted into the trachea. After measuring baseline value of the lung resist-ance (RL) and dynamic compliance of respiratory system (Cdyn), DMSO (0.3 ml/kg) and FK224 (1mg/kg) wereadministered by injection through jugular vein respectively. A rodent respirator with dry 5% CO2-95% O2 mixture atroom temperature provided mechanical ventilation ( VT 8ml/animal, 100breaths/min) for 5min. RL and Cdyn of 2groups were measured after isocapnic hyperpnea challenge. Results In DMSO control group, isocapnic hyper-pnea of dry gas elicited a marked increase in RL and decrease in Cdyn. RL and Cdyn of FK224 group did not changesignificantly. Conclusion FK224 can inhibit the increase in RL and decrease in Cdyn caused by isocapnic hy-perpnea in guinea pigs. And antagonists of tachykinins receptors might have effect on prophylaxis and treatment inexercise-induced asthma. | 陶梦非 梁永杰 | 2005 | Journal of Shanghai Second Medical University(Foreign Language Edition)2005，17，1： | 1 |
| 20 | MECHANISM OF PATHOLOGICAL CHANGES OF INTRAVENTRICULAR HEMORRHAGE IN DOGS显示文摘Objective To probe the mechanism of pathological changes of intraventricular hemorrhage (IVH). Methods The evaluation of neurological status, serial CT scans and pathological examination were applied on the canine model of lVH. The ventricular volume and blood clot volume were measured based on the CT images. Results The normal adult canine ventricle tend to be slitlike. After injection, the ventricle was obviously dilated by the blood clot. The linear regression of ventricular volume against blood clot volume was significant in the first week. From then on, however, while the clots continued to shrink, the ventricular volume showed progressive elargement. The clots were lysed completely within 3 to 4 weeks. The linear regression of the degree of ventricular dilatation against the first clot volume was also significant. In the pathological examination ,we found the ependyrnal lining of ventricular system was destroyed and neurons in the subependymal areas developed acidophil necrosis, which was prominent around Sylvian aqueduct. Conclusion Hemorrhagic ventricular dilatation (HVD) is a prominent feature of IVH and also is a strong indicator for poor prognosis. lschemic changes of periventricular neurons in some important structures may be the most direct cause for poor outcome of IVH. It may be induced by periventricular vascular structures compressed by HVD, increased intracranial pressure, cerebral vasospasm and others. | 戴炯 李善泉 李骁雄 徐斌斌 熊文浩 王勇 张晓华 沈加林 | 2004 | Journal of Shanghai Second Medical University(Foreign Language Edition)2004，16，1： | 1 |
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