Further Investigation on the Role of Selenium Deficiency in the Aetiology and Pathogenesis of Keshan Disease

查看全文 作　　者：XU GUANG-LU;WANG SHI-CHEN;GU BAI-QI;YANG YU-XUN;SONG HONG-BIN;XUE WEN-LAN;LIANG WEN-SHENG, AND ZHANG PEI-Yl(Research Laboratory of Keshan Disease, Xi’ an Medical University,Xi’ an 710061, China;Department of Pathology, Shanghai Medical University, Shan 出　　处：《Biomedical and Environmental Sciences》索引1997年第10卷第2期,共11页 摘　　要：Selenium supplements were not able to restore the ultrastructural changes in the myocardiurn of latent Keshan disease patients taken by using cardiac catheter endomyocardial biopsy. Observations on the changes of seleniurn status and the incidence of Keshan disease showed that new latent and naturally-occurring chronic cases were found in the endemic area even after selenium levels had been elevated in the residents to the levels typical in the non-endemic area. These results indicate that although selenium deficiency might be a primary pathogenetic geogen in the occurrence of Keshan disease, it is rather a conditional predisposing factor than a specific or initiative aetiologic factor for the occurrence of Keshan disease. Selenium supplmentation could apparently alleviate the higher platelet responsiveness of residents in the endemic area, which might contribute to eliminating the basis for the occurrence of the multifocal perivascular necroses in myocardium of acute and subacute Keshan 关 键 词：发病机制 病因 克山病 硒