A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

查看全文 作　　者：Yinghua [1]Zhao;Liyan [1]Sui;Ping [2]Wu;Wenfang [3]Wang;Zedong [1]Wang;Yang [4]Yu;Zhijun [2]Hou;Guangyun [1]Tan;Quan [1,2,5,6]Liu;Guoqing [3]Wang

机构地区：[1]Center for Pathogen Biology and Infectious Diseases,Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education,The First Hospital of Jilin University,State Key Laboratory of Human-Animal Zoonotic infectious Diseases,Changchun,China;[2]College of Wildlife and Protected Area,Northeast Forestry University,Harbin,China;[3]Department of Pathogenbiology,The Key Laboratory of Zoonosis,Chinese Ministry of Education,College of Basic Medicine,Jilin University,Changchun,China;[4]Hospital of Stomatology,Jilin University,Changchun,China;[5]School of Life Sciences and Engineering,Foshan University,Foshan,China;[6]Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Guangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第10期,共14页

基　　金：supported by grant from National Natural Science Foundation of China(81972873,81871699,82072330);the Pearl River Talent Plan in Guangdong Province of China(2019CX01N111);the Science and Technology Innovation Project in Foshan and Guangzhou,Guangdong Province,China(2020001000151,202103000008);the Foundation of Jilin Province Science and Technology Department(172408GHO10234983 and 20200301001RQ);the 68th batch of first-class funding from China Postdoctoral Science Foundation(2020M680044). 摘　　要：The recently emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is the causative agent of ongoing global pan demic of COVID-19,may trigger imm uno suppression in the early stage and overactive immune resp onse in the late stage of infection;However,the un derlying mecha nisms are not well understood.Here we dem on strated that the SARS-CoV-2 nucleocapsid(N)protein dually regulated innate immune responses,i.e.,the low-dose N protein suppressed type I interferon(IFN-I)signaling and inflammatory cytokines,whereas high-dose N protein promoted IFN-I signaling and inflammatory cytokines.Mechanistically,the SARS-CoV-2 N protein dually regulated the phosphorylation and nuclear translocation of IRF3,STAT1,and STAT2.Additi on ally,low-dose N protein combined with TRIM25 could suppress the ubiquitination and activatio n of retinoic acidinducible gene I(RIG-I).Our findings revealed a regulatory mechanism of innate immune responses by the SARS-CoV-2 N protein,which would contribute to understanding the pathogenesis of SARS-CoV-2 and other SARS-like coronaviruses,and development of more effective strategies for controlling COVID-19. 关键词：INTERFERON RESPIRATORY ACUTE

相关文献

参考文献（48）
引证文献（8）
耦合文献（599）

参考文献(48)

引证文献(8)

耦合文献(599)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

参考文献(48)

引证文献(8)

耦合文献(599)

用户提示