GDNF to the rescue:GDNF delivery effects on motor neurons and nerves,and muscle re-innervation after peripheral nerve injuries

查看全文 作　　者：Alberto F.Cintrón-[1]Colón;Gabriel Almeida-[1]Alves;Juliana [1]M.VanGyseghem;John [1]M.Spitsbergen

机构地区：[1]Biological Sciences Department,Western Michigan University,Kalamazoo,MI,USA

出　　处：《Neural Regeneration Research》索引2022年第17卷第4期,共6页

基　　金：funded by the NIH Grant 1R15AG022908-01A2 and the Western Michigan University(to JMS)。 摘　　要：Peripheral nerve injuries commonly occur due to trauma,like a traffic accident.Peripheral nerves get severed,causing motor neuron death and potential muscle atrophy.The current golden standard to treat peripheral nerve lesions,especially lesions with large(≥3 cm)nerve gaps,is the use of a nerve autograft or reimplantation in cases where nerve root avulsions occur.If not tended early,degeneration of motor neurons and loss of axon regeneration can occur,leading to loss of function.Although surgical procedures exist,patients often do not fully recover,and quality of life deteriorates.Peripheral nerves have limited regeneration,and it is usually mediated by Schwann cells and neurotrophic factors,like glial cell line-derived neurotrophic factor,as seen in Wallerian degeneration.Glial cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite outgrowth.Glial cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy,sciatic nerve crush,and compression,thus creating great interest to explore this protein as a potential treatment for peripheral nerve injuries.Exogenous glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve injuries.In this review,we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor,the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries,delivery systems,and complementary treatments(electrical muscle stimulation and exercise).Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients'quality of life. 关键词：electrical muscle stimulation exercise glial cell line-derived neurotrophic factor glial cell line-derived neurotrophic factor delivery motor neuron nerve gap neurotrophic factor peripheral nerve injury Schwann cells skeletal muscle atrophy

相关文献

参考文献（68）
引证文献（11）
耦合文献（29）

参考文献(68)

引证文献(11)

耦合文献(29)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

GDNF to the rescue:GDNF delivery effects on motor neurons and nerves,and muscle re-innervation after peripheral nerve injuries

参考文献(68)

引证文献(11)

耦合文献(29)

用户提示