The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies

查看全文 作　　者：Adriana Octaviana [1]Dulamea

机构地区：[1]Department of Neurology, Fundeni Clinical Institute, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania

出　　处：《Neural Regeneration Research》索引2017年第12卷第12期,共6页

摘　　要：Oligodencrocytes(OLs) are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis(MS), there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells(OPCs) and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies. 关键词：multiple sclerosis oligodencrocytes oligodendrocyte progenitor cells DEMYELINATION REMYELINATION semaphorin basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2 leucin-rich repeat and immunoglobulin-like-domain-containing nogo receptor-interacting protein 1 canonical Notch signaling endocrine receptors

相关文献

参考文献(106)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费