Polymorphism of the DNA repair gene XPA and susceptibility to lung cancer

查看全文 作　　者：Jinfu [1]Zhu;Zhibin [2]Hu;Hongxia [2]Ma;Xiang [2]Huo;Lin [3]Xu;Jiannong [3]Zhou;Hongbing [2]Shen;Yijiang [1]Chen 机构地区：[1]Department of Thoracic & Cardiac Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;[2]Department of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University,Nanjing 210029, China;[3]Department of Thoracic Surgery, Jiangsu Cancer Hospital,Nanjing 210009, China 出　　处：《Journal of Nanjing Medical University》索引2005年第19卷第4期,共4页 基　　金：NationalNaturalScienceFoundationofChina(30371240)andInnovativeFoundationofNanjingMedicalUniversity(CX2003005)Received23/11/04 摘　　要：Objective: To study the relationship between one polymorphism in the promoter of the DNA repair gene XPA and the susceptibility to lung cancer. Methods: Genotypes were determined by the PCR-restriction fragment length polymorphism (PCR-RFLP) method in 310 histologically-confirmed lung cancer cases and 341 age and sex frequency-matched cancer-free controls. Results: The XPA A23G genotype frequencies were 27.1% (AA), 42.9% (AG), and 30.0% (GG) in case patients and 21.1% (AA), 52.8% (AG), and 26.1% (GG) in control subjects. Multivariate logistic regression analysis revealed that individuals carrying at least one 23G variant allele (AG+GG genotypes) had a significantly decreased risk for lung cancer (adjusted OR=0.66; 95%CI=0.44-0.98) compared with the wild-type genotype (23AA). Stratified analysis showed that the protective effect was more evident in subjects with a family history of cancer. Conclusion: These results suggest that the XPA A23G polymorphism may have a role in lung cancer susceptibility in this study population. 关 键 词：基因多态性 DNA修复基因 XPA 易感性 肺癌