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| 1 | The synthesis of 6-(tert-butyl)-8-fluoro-2,3-dimethylquinoline carbonate derivatives and their antifungal activity against Pyricularia oryzae显示文摘A series of novel 6-(/er/-butyl)-8-fluoro-2,3- dimethylquinoline carbonate derivatives were designed and synthesized. Bioassay results showed that some of them exhibited good activity against Pyricularia oryzae (P. oryzae). It was found that the compound 5q (benzyl (6-(tert-butyl)-8-fluoro-2,3-dimethylquinolin-4-yl) carbonate) possessed good activity against P. oryzae whatever protective activity (10 mg·L^-1) or curative activity (25 mg·L^-1), which was better than that of control tebufloquin. In addition, the frontier molecular orbit results revealed that the compound held higher activity against P. oryzae when the total energy was low and the ClogP was high, which may provide useful information for further design novel fungicides. | Long Cheng Ruirui Zhang Hongke Wu Xinghai Liu Tianming Xu | 2019 | Frontiers of Chemical Science and Engineering2019，13，2： | 8 |
| 2 | Novel indole and quinoline alkaloids from Melodinus yunnanensis显示文摘6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-vincamenine(5)were isolated from Melodinus yunnanensis.All structures were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.The isolation of monoterpenoid indole,quinoline,and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole.Compound 2 was cytotoxic against several human cancer cell lines. | Xiang-Hai CAI Yan LI Jia SU Ya-Ping LIU Xiao-Ning LI Xiao-Dong LUO | 2011 | Natural Products and Bioprospecting2011，1，1： | 4 |
| 3 | 聚(4-乙烯基吡啶丁烷磺酸)硫酸氢盐:一个高效的多相聚(离子液体)固体酸催化剂用于无溶剂条件下一锅法合成1-酰氨基-2-萘酚和取代喹啉(英文)显示文摘Poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate has been used as an efficient dual acidic catalyst for the one-pot preparation of 1-amidoalkyl-2-naphthols and substituted quinolines under solvent-free conditions.The catalyst was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and thermo-gravimetric analysis. The results revealed several advantages to our new catalyst system,including its reusability,facile work-up procedure, eco-friendly reaction conditions,short reaction time,and high product yields. | Ali Reza Kiasat Arash Mouradzadegun Seyyed Jafar Saghanezhad | 2013 | 催化学报2013，34，10： | 3 |
| 4 | Removal of Basic Nitrogen Compounds from Diesel Fraction with NMP-0.5ZnCl_(2) Coordinated Ionic Liquid显示文摘An inexpensive coordinated ionic liquid NMP-0.5ZnCl_(2) was synthesized by reacting N-methyl-pyrrolidone with anhydrous ZnCl_(2),and its structure was characterized with FT-IR spectroscopy.The performance of IL for removing basic nitrogen compounds from model oil containing quinoline and actual coker diesel was studied.Experimental results showed that the IL,NMP-0.5ZnCl_(2),exhibited a good denitrogenation performance,which can be attributed to its low viscosity and unoccupied orbitals of Zn ion,while obtaining a 99.68%quinoline removal efficiency under conditions covering a temperature of 50℃,an IL/model oil mass ratio of 1:2,and a reaction time of 30 min.In the case of coker diesel,above a 91%basic N-removal efficiency(with N-content reduced from 536μg/g to 47μg/g)was realized by the IL after 5-stage extraction.Moreover,the quinoline extraction efficiency could still reach 96.73%during four recycles of the IL. | Li Wenshen Ren Yongqi Li Jianxiang Zhao Zhijun Liu Jie | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 3 |
| 5 | Quinoline alkaloids isolated from Scolopendra subspinipes mutilans显示文摘Objective: To study the quinoline alkaloids from the ethanol extract of Scolopendra subspinipes mutilans(SSM).Methods: The chemical constituents were isolated and purified by macroporous resin column, medium pressure preparation chromatography, and semi-preparative HPLC. Their structures were elucidated by IR,MS, and NMR experiments.Results: Three quinolone alkaloids were obtained and identified as 3-hydroxy-4-methoxyquinolin-8-yl hydrogen sulfate(1), jineol-8-sulfate(2), and jineol(3), respectively.Conclusion: Compound 1 is a new compound from SSM. | Yan-fang Li Wu-zhan Liu Jian-wei Fan Chuan-liang Huang Li-hua Deng Hui-fang Zhuang Yong-xia Guan | 2019 | Chinese Herbal Medicines2019，11，3： | 2 |
| 6 | Bioaugmentation: a new strategy for removal of recalcitrant compounds in wastewater—a case study of quinoline显示文摘IntroductionInrecentyearsxenobioticshavecaughtworldsattentionbecausetheyarepoorlybiodegradableandthreatenpublichealthifhandle... | HAN Li\|ping\+*, WANG Jian\|long, SHI Han\|chang, QIAN Yi (State Key Joint Laboratory of Environmental Simulation and Pollution Control, Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China) Foundation item | 2000 | Journal of Environmental Sciences2000，12，1： | 2 |
| 7 | Quasi-continuous synthesis of cobalt single atom catalysts for transfer hydrogenation of quinoline显示文摘Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synthesis S,N co-doped carbon supported Co single atom catalysts(Co/SNC),which was used for transfer hydrogenation of quinoline with formic acid as the hydrogen donor.Given the unique ge-ometric and electronic properties of the Co single atoms,the excellent catalytic activity,selectivity and stability were observed.Benefiting from the quasi-continuous synthesis method,the as-obtained cata-lysts provide a reference for the large-scale preparation of single atom catalysts without amplification ef-fect.Highly catalytic performances and quasi-continuous preparation process,demonstrating a new and promising approach to rational design of atomically dispersed catalysts with maximum atomic efficiency in industrial. | Liyun Huang Hao Zhang Yujie Cheng Qingdi Sun Tao Gan Qian He Xiaohui He Hongbing Ji | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 8 | Charge effects on quinoline hydrodenitrogenation catalyzed by Ni-Mo-S active sites-A theoretical study by DFT calculation显示文摘The charge distribution on Ni-Mo-S active sites can affect hydrodenitrogenation(HDN)activity.In this study,a series of model Ni-Mo-S were developed with various charge distributions.For comparison,the charge distribution effects on quinoline HDN were studied.The results show that a lack of electrons and extra protons can both lower the orbital eigenvalue of the Ni-Mo-S,leading to stronger adsorption of nitrogen-containing compounds and inhibition of ammonia desorption.Electron deficiency will improve the generation of active hydrogen on the active sites but inhibit hydrogen transfer to the nitrogen compounds;extra protons can provide H^(+)to the nitrogen compounds,which will flexibly transfer between the nitrogen compound and active sites,thus improving the cleavage of the C-N bond. | Si-Jia Ding Shao-Zhong Peng Zuo-Jie Yan Ji-Feng Wang Shu-Jiao Jiang Zhan-Lin Yang | 2022 | Petroleum Science2022，19，1： | 1 |
| 9 | Breaking the activity limitation of iridium single-atom catalyst in hydrogenation of quinoline with synergistic nanoparticles catalysis显示文摘Single-atom catalysts(SACs)with the advantages of homogeneous and heterogeneous catalysts have become a hot-spot in catalysis field.However,for lack of metal–metal bond in SACs,H_(2)has to go through heterolytic dissociation pathway,which has higher barrier than homolytic dissociation pathway,and thus limits the hydrogenation activity of SACs.Herein,we propose and demonstrate through constructing synergistic iridium single atoms and nanoparticles co-existed catalyst(denoted as Ir_(1+NPs)/CMK)to boost the catalytic activity of quinoline hydrogenation.Both experimental and density functional theory calculation results confirm that Ir_(1)single sites activate quinoline,while Ir nanoparticles boost hydrogen dissociation.H atoms generated at Ir nanoparticles migrate to the quinoline bounded Ir_(1)single sites to complete hydrogenation.The Ir_(1+NPs)/CMK catalyst exhibits much higher reactivity with turnover frequency of 7,800 h^(−1)than those counterpart Ir_(1)/CMK and IrNPs/CMK catalysts,and is 20,000 times higher activity of commercial Ir/C benchmark catalyst for hydrogenation of quinoline under the same reaction conditions.This synergistic catalysis strategy between single atoms and nanoparticles provides a solution to further improve the performance of SACs for hydrogenation. | Qikai Shen Hongqiang Jin Peipei Li Xiaohu Yu Lirong Zheng Weiguo Song Changyan Cao | 2022 | Nano Research2022，15，6： | 0 |
| 10 | AuPt bimetallic nanoalloys supported on SBA-15:A superior catalyst for quinoline selective hydrogenation in water显示文摘The structure and size of bimetallic catalysts play a crucial role in many important chemical transformations.Controlled synthesis of bimetallic nanoparticles avoiding overgrowth and aggregation can be achieved by surfactants,which are always detrimental to catalytic performances and understanding of structure-property relationship.Preparation of surface-clean bimetallic catalysts with uniform size and well-defined structure is still challenging.Herein the Au-Pt bimetallic nanoparticles immobilized on SBA-15 were prepared by facile adsorption-reduction method.Characterizations showed that Au-Pt bimetallic nanoparticles were evenly confined within the mesopores of SBA-15,possessing the uniform size of 6.0 nm and existing in the form of alloy structure.For the first time the Au-Pt bimetallic nanoalloys with Au-to-Pt molar ratio of 5:1(Au5Pt1@SBA-15)exhibited a lot higher activity than monometallic Au@SBA-15 and Pt@SBA-15 catalysts with excellent selectivity towards 1,2,3,4-tetrahydroquinoline for chemoselective hydrogenation of quinoline in water under very mild conditions.It was superior to other heterogeneous catalysts reported to date.The observed properties were related to the synergic effect between Au and Pt.The Pt sites of high electron density originated from the electron transfer between Au and Pt enhanced the ability of H_(2) dissociation and then provided a new and main approach to H_(2) splitting,while the Au sites accounted for the adsorption and activation of quinoline.This precise synthetic strategy will be very helpful to explore surface-clean gold-based bimetallic catalysts with high performance for selective hydrogenations. | Jianbo Zhao Haifeng Yuan Guang Yang Yingfan Liu Xiaomei Qin Zheng Chen Cheong Weng-Chon Liming Zhou Shaoming Fang | 2022 | Nano Research2022，15，3： | 0 |
| 11 | Clinical Use of COX-2 Inhibitors Containing Quinoline Heterocycle as a Selective Therapeutic Agents for Complementary Medicine显示文摘Inflammation represents an initial response of immune system and is involved in a number of biochemical inci-dents.Such incidents may multiply and further develop the provocative response.Over the past 15 years,various classes of secondary metabolites that were isolated from plant and marine sources have been described as natural cyclooxygenase(COX)inhibitors.The majority of natural COX inhibitors could be used as a selective therapeutic agent for complementary medicine and clinical applications.Currently,the inflammation is commonly treated by non-steroidal anti-inflammatory drugs(NSAIDs),several medications of which,however,have been linked to renal and gastrointestinal side effects.A variety of inhibitors of COX-2 that are selective(celecoxib,rofecoxib,valdecoxib and others)have been designed as NSAIDs mostly with enhanced stomach safety profiles.This helps to improve the compliance and functions in the geriatric patients as they have so many complications and problems associated with the diseases.The use of complementary medicine in combination with clinical therapy might give better results than medicine alone.Some disease condition like cancer which shows the COX-2 expressions could also have treatment related problems in such cases the selective inhibitors used as a complementary medicine.On the other hand,elevated cardiovascular risks have brought increasing worries about the safety of using specific inhibitors of COX-2.This current review focuses on how quinoline heterocycle was used for creation of inhibitors of COX-2 since 2009 along with its clinical significance in complementary medicine.These agents included the variety of substituents on the ring or ring attached to other heterocycles.As a result,the quinoline heterocycle will be used for creating and finding anti-inflammatory COX-2 medicines. | Megha P.Ambatkar Nilesh R.Rarokar Pramod B.Khedekar | 2023 | Clinical Complementary Medicine and Pharmacology2023，3，3： | 0 |
| 12 | 一种功能性轴向配位基的合成显示文摘二氧四胺大环(macrocyclic dioxotetraanine)配体因其独特的结构特点和性质而受到广泛的重视和关注.本文合成了一种溴代杂环8—溴代甲基喹淋,并作为功能性轴向给体侧臂成功地引入到十三员、十四员二氧四胺大环骨架上,发现喹啉侧臂的引入。 | 安道利 | 1997 | 晋中学院学报1997，20，1： | 0 |
| 13 | SYNTHESIS OF 2-OXOALKYLPHOSPHONATES显示文摘α, β-Unsaturated ketones (Ⅱ) can be prepared by the Horner-Emmons-Wittig condensation of the sodio derivative of 2-oxoalkylphosphonates (Ⅰ) with aldehydes or ketones. The condensation is often carried out under mild conditions with double bond formed in trans orientation. The reaction is quite useful in the synthesis of | 吴元鎏 金碧燕 胡家玉 杨光中 | 1984 | Chinese Science Bulletin1984，29，2： | 0 |
| 14 | NEW AND SIMPLE CORRELATIONS FOR ESTIMATING CRITICAL TEMPERATURES显示文摘Ⅰ. INTRODUCTION Critical temperature of pure substance is one of the most important physical properties in theoretical scientific studies and various engineering fields. However, the critical temperatures of most substances must now be estimated from certain | 王乃绪 | 1983 | Chinese Science Bulletin1983，28，5： | 0 |
| 15 | Naphthalimide and quinoline derivatives as inhibitors for insect N-acetyl-β-D-hexosaminidase显示文摘Insect chitinolyticβ-N-acetyl-D-hexosaminidase,such as OfHex1 from Ostrinia furnacalis,is a potential target for insecticide design.Among the known OfH ex1 inhibitors,Q2 is of great interest because it is the first non-carbohydrate inhibitor.In this study,we designed and synthesized a series of Q2 derivatives by replacing the thiadiazole and naphthalimide groups and changing the linker length.Compound 3 m showed the best inhibitory activity with a Kivalue of 0.34 mmol/L against OfHex1,which is about onequarter that of Q2(K_i=1.4 mmol/L).Compound 6 a showed the best inhibitory activity among the quinoline-containing derivatives(K_i=2.3 mmol/L).Molecular docking indicated that although 3 m,6 a,and Q2 binding the active pocket of OfHex1 in similar mode,compound 3 m engaged better than the other compounds in intermolecular interaction with OfH ex1. | Huibin Yang Huitang Qi Tian Liu Xusheng Shao Qing Yang Xuhong Qian | 2019 | Chinese Chemical Letters2019，30，5： | 0 |
| 16 | SYNTHESIS AND COMPLEXATION PROPERTIES OF NEW DIOXO TETRAAMINE LIGANDS WITH 8-METHYL QUINOLINE AS FUNCTIONAL PENDANT(S)显示文摘SYNTHESIS AND COMPLEXATION PROPERTIES OF NEW DIOXO TETRAAMINE LIGANDS WITH 8-METHYL QUINOLINE AS FUNCTIONAL PENDANT(S)SYNTHES... | Dao Li AN Xian He BU Hua Kuan LIN Yu LIU and Yun ti CHEN (Department of Chemistry, Nankai University, Tianjin 300071) | 1994 | Chinese Chemical Letters1994，5，6： | 0 |
| 17 | Biodegradation Kinetics and Mechanism of a Typical Coal Gasification Pollutant:Quinoline显示文摘A strain Pseudomonas sp.PP1 was isolated from activated sludge and characterized by morphological observation,biochemical and physiological identification as well as 16 S rRNA gene sequence analysis.It was a gram-negative,non-motile,rod-shaped with colonies which were white,opaque,small and wrinkled on solid quinoline-MSM.The strain was negative for catalase,gelatin liquefaction,M.R and V.P tests and was unable to reduce / restore nitrate.The 1406 bp 16 S rRNA gene fragment of PP1 was more than 99% identical to the Pseudomonas sp.Biodegradation of quinoline as single substrate was conducted in batch experiments at different temperatures( 15- 40 ℃) and p H values( 5- 10).The results indicate that the optimum conditions for the degradation of quinoline by PP1 were 30 ℃ and p H 7.Pseudomonas sp.PP1 was able to degrade 97.1%,95.4%,94.8%,63.6% and 40.4% quinoline when initial concentrations of quinoline were 50,100,200,300,and 400 mg / L,respectively,and lag phases were prolonged from 2 h to 10 h.The maximum degradation rate( q) was obtained at an initial quinoline concentration( S0) of about 100 mg/L with q of 0.082.The experimentally obtained q values at various initial S0 were fitted by Haldane model,Yano model,Aiba model,Edward model and Webb model,and the results demonstrated that Haldane model gives the best fit for strain PP1 with coefficient of determination,R2= 0.9124 and SDavg= 0.0113208.Five metabolic intermediates were identified by high performance liquid chromatograph( HPLC) and GC / MS.Finally,a possible pathway containing 5,6-dihydroxy-2-oxo-1,2-dihydroquinoline as an intermediate was proposed for the first time. | Peng Xu Hong-Jun Han Sheng-Yong Jia Bao-Lin Hou Hai-Feng Zhuang Qian Zhao | 2014 | Journal of Harbin Institute of Technology(New Series)2014，21，6： | 0 |
| 18 | Quinoline-based aggregation-induced delayed fluorescence materials for highly efficient non-doped organic light-emitting diodes显示文摘Three new emitters,namely 10,10’-(quinoline-2,8-diyl)bis(10 H-phenoxazine)(Fene),10,10’-(quinoline-2,8-diyl)bis(10 H-phenothiazine)(Fens) and 10,10’-(quinoline-2,8-diyl)bis(9,9-dimethyl-9,10-dihydroacridine)(Yad),featuring quinoline as a new electron acceptor have been designed and conveniently synthesized.These emitters possessed small singlet-triplet splitting energy(ΔEst) and twisted structures,which not only endowed them show thermally activated delayed fluorescence(TADF)properties but also afforded a remarkable aggregation-induced emission(AIE) feature.Moreover,they also showed aggregation-induced delayed fluorescence(AIDF) property and good photoluminescence(PL) property,which are the ideal emitters for non-doped organic light-emitting diodes(OLEDs).Furthermore,high-performance non-doped OLEDs based on Fene,Fens and Yad were achieved,and excelle nt maximum external quantum efficiencies(EQEmax) of 14,9%,13.1% and 17,4%,respectively,were obtained.It was also found that all devices exhibited relatively low turn-on voltages ranging from 3.0 V to3.2 V probably due to their twisted conformation and the AIDF properties.These results demonstrated the quinoline-based emitters could have a promising application in non-doped OLEDs. | Liang Zhang Yin-Feng Wang Meng Li Qing Yu Gao Chuan-Feng Chen | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 19 | Removal of Basic and Non-Basic Nitrogen Compounds from Model Oil by FeCl_(3)-Based Ionic Liquids显示文摘The low-viscosity FeCl_(3)-based ionic liquids(ILs)prepared from the interaction of anhydrous FeCl_(3) and alkyl imidazolium bromide([1-alkyl-3-methyl-imidazolium]Br,alkyl=ethyl,butyl,hexyl,octyl)are highly effective for the denitrogenation of model oil containing quinoline or indole.The results indicate that the chain length of the alkyl group on the imidazolium cation has little influence on the N-extraction efficiency.With the selected IL[Bmim]Br/FeCl_(3),up to 99.1%of N-extraction efficiency from model oil containing quinoline can be attained at an extraction temperature of 30°C with an IL/oil mass ratio of 1/7 and an extraction time of 30 min.The indole extraction efficiency reaches 98.9%at an IL/oil mass ratio of 1:1.Moreover,the quinoline extraction efficiency remains as high as 92.3%after the IL has been recycled four times. | Li Wenshen Liu Jie | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，4： | 0 |
| 20 | Synthesis and Photoelectrical Properties of D-A Type Carbazole-quinoline显示文摘The key issues concerning the design and synthesis of high fluorescent efficiency, good thermal stability of organic blue materials should be solved urgently in organic light emitting diodes. In this article, three D-A type blue emitters based on carbazole and phenylquinoline with flexible chains were prepared through Friedlander condensation reaction in relatively high yield. The photoelectric properties of all compounds were studied by UV-vis absorption, emission spectra and cyclic voltammograms. Density functional theory calculations(DFT) were performed to obtain a better understanding of the electronic structures. Interestingly, compound a3 with the highest fluorescence quantum yield of 0.53 can be applied into blue light emission materials on account of good thermal performance. Furthermore, a1~a3 with narrow band gap make them become potential candidates in the fields of OLED, solar cells and OFET. | 刘山 | 2018 | Chinese Journal of Structural Chemistry2018，37，4： | 0 |
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