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| 1 | Efficacy and safety of vildagliptin in clinical practice-results of the PROVIL-study显示文摘AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T2DM) previously on oral monotherapy were selected by their treating physician to receive either vildagliptin addon to metformin(cohort 1),vildagliptin+metformin single-pill combination(SPC)(cohort 2)or another dual combination therapy with oral antidiabetic drugs(OADs)(cohort 3).According to routine clinical practice,interim examinations occurred every 3 mo:at baseline,after approximately 3 mo and after approximately 6 mo.Parameters documented in the study included demographic and diagnostic data,history of T2DM,data on diabetes control,vital signs,relevant prior and concomitant medication and disease history.Efficacy was assessed by changes in HbA1c and fasting plasma glucose(FPG)3 mo and 6 mo after initiation of dual combination therapy.Safety was assessed by adverseevent reporting and measurement of specific laboratory values(serum creatinine,total bilirubin,alanine aminotransferase,aspartate aminotransferase,creatine kinase).RESULTS:Between October 2009 and January 2011,a total of 3881 patients were enrolled in this study.Since 47 patients were withdrawn due to protocol violations,3834 patients were included in the statistical analysis.There were no relevant differences between the three cohorts concerning age,body weight and body mass index.Average diabetes duration was approximately 6 years and mean HbA1c was between 7.6%and 7.9% at baseline.Antidiabetic treatment was recorded in 3648 patients.Patients were treated with vildagliptin add-on to metformin(n=603),vildagliptin+metformin(SPC)(n =2198),and other oral OADs including combinations of metformin with sulfonylurea(n=370),with glitazones(n =123),other dipeptidyl peptidase-4 inhibitors(n=99).After 6 mo of treatment,the absolute decrease in HbA1c(mean±SE)was significantly more pronounced in patients receiving vildagliptin add-on to metformin(-0.9% ±0.04%)and vildagliptin+metformin(SPC)(-0.9%± 0.03%)than in patients receiving other OADs(-0.6% ±0.04%;P<0.0001).In addition,significant cohort differences were observed for the improvement in FPG after 6 mo treatment(vildagliptin add-on to metformin:-291 mg/L±18.3 mg/L;vildagliptin+metformin(SPC):-305 mg/L±9.6 mg/L;other antidiabetic drugs:-209 mg/L±14.0 mg/L for(P<0.0001).Moderate decreases in body weight(absolute difference between last control and baseline:mean±SE)were observed for patients in all cohorts(vildagliptin add-on to metformin:-1.4 kg ±0.17 kg;vildagliptin+metformin(SPC):-1.7 kg± 0.09 kg;other OADs:?0.8 kg±0.13 kg).No significant differences in adverse events(AEs)and other safety measures were observed between the cohorts.When performing an additional analysis by age(patients<65 years vs patients≥65 years),there was no relevant difference in the most common AEs between the two age groups and the AE profile was similar to that of the overall patient population.CONCLUSION:Clinical practice confirms that vildagliptin is an effective and well-tolerated treatment in combination with metformin in T2DM patients. | Matthias Blüher Ira Kurz Simone Dannenmaier Markus Dworak | 2012 | World Journal of Diabetes2012，3，9： | 9 |
| 2 | Comparison of dark energy models:A perspective from the latest observational data显示文摘We compare some popular dark energy models under the assumption of a flat universe by using the latest observational data including the type Ia supernovae Constitution compilation,the baryon acoustic oscillation measurement from the Sloan Digital Sky Survey,the cosmic microwave background measurement given by the seven-year Wilkinson Microwave Anisotropy Probe observations and the determination of H0 from the Hubble Space Telescope.Model comparison statistics such as the Bayesian and Akaike information criteria are applied to assess the worth of the models.These statistics favor models that give a good fit with fewer parameters.Based on this analysis,we find that the simplest cosmological constant model that has only one free parameter is still preferred by the current data.For other dynamical dark energy models,we find that some of them,such as the αdark energy,constant w,generalized Chaplygin gas,Chevalliear-Polarski-Linder parametrization,and holographic dark energy models,can provide good fits to the current data,and three of them,namely,the Ricci dark energy,agegraphic dark energy,and Dvali-Gabadadze-Porrati models,are clearly disfavored by the data. | LI Miao1,2,LI XiaoDong2,3 & ZHANG Xin1,4 1Kavli Institute for Theoretical Physics China,Chinese Academy of Sciences,Beijing 100190,China 2Key Laboratory of Frontiers in Theoretical Physics,Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190,China 3Interdisciplinary Center for Theoretical Study,University of Science and Technology of China,Hefei 230026,China 4Department of Physics,College of Sciences,Northeastern University,Shenyang 110004,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，9： | 7 |
| 3 | Hepatitis B or C viral infection and risk of pancreatic cancer: A meta-analysis of observational studies显示文摘AIM: To investigate if there is an association between hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the risk of pancreatic cancer. METHODS: All relevant studies published before 11 October, 2012 were identified by a systematic search of MEDLINE, EMBASE, BIOSIS Previews and the Cochrane Library databases and with cross-referencing. The observational studies that reported RR or OR estimates with 95%CIs for the association between HBV or HCV and pancreatic cancer were included. A random-effects model was used to summarize meta-analytic estimates. The Newcastle-Ottawa quality assessment scale was applied to assess the quality of the methodology in the included studies. RESULTS: A total of 8 eligible studies were selected for meta-analysis. Overall, chronic hepatitis B and inactive hepatitis B surface antigen (HBsAg) carrier state (HBsAg positive) had a significantly increased risk of pancreatic cancer with OR of 1.20 (95%CI: 1.01-1.39), especially in the Chinese population (OR = 1.30, 95%CI: 1.05-1.56). Past exposure to HBV (possible occult HBV infection) had an increased OR of pancreatic cancer risk (OR = 1.24, 95%CI: 1.05-1.42), especially among those patients without natural immunity [anti hepatitis B core (HBc) positive/hepatitis B surface antibody (anti HBs) negative], with OR of 1.67 (95%CI: 1.13-2.22). However, past exposure to HBV with natural immunity (anti-HBc positive/anti-HBs positive) had no association with pancreatic cancer development, with OR 0.98 (95%CI: 0.80-1.16), nor did the HBV active replication (hepatitis B e antigen positive status), with OR 0.98 (95%CI: 0.27-1.68). The risk of pancreatic cancer among anti-HBs positive patients was significantly lower than among anti-HBs negative patients (OR = 0.54, 95%CI: 0.46-0.62). Past exposure to HCV also resulted in an increased risk of pancreatic cancer (OR = 1.26, 95%CI: 1.03-1.50). Significant between-study heterogeneity was observed. Evidence of publication bias for HBV/HCV infection-pancreatic cancer association was not found. CONCLUSION: Chronic HBV and HCV infection increases pancreatic cancer risk. Our findings underscore the need for more studies to confirm this potential relationship. | Jian-Hua Xu Jin-Jian Fu Xiao-Li Wang Jia-Yong Zhu Xiao-Hua Ye Si-Dong Chen | 2013 | World Journal of Gastroenterology2013，19，26： | 6 |
| 4 | 临床数据向通用数据模型转换研究及应用实践显示文摘目的:通过参与OHDSI(ObservationalHealthDataSciencesandInformatics)研究,挖掘临床大数据的价值,评估OHDSI研究在国内的可行性,并探讨OHDSI研究的有效方法。方法:建立标准化的OMOP通用数据模型(CDM),并成功导入临床数据,在此基础上建设了临床医疗大数据科研分析平台,选择高血压、2型糖尿病、抑郁症三个慢病进行分析研究。结果:分析了高血压、2型糖尿病、抑郁症的治疗路径(用药品种与顺序),并进行了数据可视化,生成图形与图表。结论:通用数据模型的使用,既可实现全院级的科研数据的整合,也在充分保护患者隐私的前提下,为跨医院、跨区域的科研数据共享提供了一个良好的基础,可借助大数据技术开展大规模的合作式科研。 | 张昕 缪姝妹 戴作雷 殷悦楚楚 王忠民 王理 王强 刘云 | 2018 | 中国数字医学2018，13，10： | 6 |
| 5 | EVALUATION OF THE PARAMETERIZATION SCHEMES AND NUDGING TECHNIQUES IN GRAPES FOR WARM SECTOR TORRENTIAL RAINS USING SURFACE OBSERVATIONS显示文摘Sensitivities of parameterization schemes were conducted based on the Global/Regional Assimilation and Prediction System(GRAPES) model. Surface observations were used to evaluate the simulations and to improve the model’s ability to simulate the extreme precipitation over southern China on 20 July 2016. The results showed that GRAPES captured the large-scale precipitation over southern China but failed to predict the extreme precipitation over Xinyi. The model showed a systematic cold biases by adopting different parameterization schemes. In particular, the ECMWF analyses data showed a strong cold bias over Guangdong province and Guangxi region. Observational nudging results showed that the surface temperature could largely help to alleviate the cold bias. The alleviation in the warm sector accounted for main improvement by the nudging scheme, and the RMSE was reduced by 1.56 degree from 3.25 degree to 1.69 degree by 1-h simulation and with 1.3 degree alleviation by 2-h simulation. Sensitivities using different parameterizations and the nudging scheme showed that the model’s underestimation of the precipitation was still present despite improvements in the predictions of surface temperature. | 钟水新 杨帅 陈子通 | 2019 | Journal of Tropical Meteorology2019，25，3： | 6 |
| 6 | INTRACLOUD LIGHTNING DISCHARGES IN THE LOWER PART OF THUNDERCLOUD显示文摘From analysis of observational data of thunderstorms in Gansu,China,it was deduced that the electricstructure of thunderclouds in this region is often positive charge in the upper,main negative in the middlelayer and another positive charge,large in magnitude and extensive in dimension,in the lower part.Intra-cloud discharges often take place between the main negative charge and lower positive charge instead of upper.Case analysis of 6 intracloud discharges in two storms on August 3 and 4,1986 shows that the centers of thesedischarges and the dipole moments destroyed were at the altitude of 3.8—6 km msl(7.6—-13.5℃)and 18—40 C km,respectively. | 刘欣生 叶宗秀 邵选民 王才伟 言穆弘 郭昌明 | 1989 | Acta meteorologica Sinica1989，3，2： | 6 |
| 7 | Observational Study on the Onset of the South China Sea Southwest Monsoon显示文摘ObservationalStudyontheOnsetoftheSouthChinaSeaSouthwestMonsoonYanJunyue(阎俊岳)NationalClimateCenter,Beijing100081ReceivedNovemb... | 阎俊岳 | 1997 | Advances in Atmospheric Sciences1997，14，2： | 5 |
| 8 | Factors associated with seeking western or Chinese medical treatment for fertility among women with breast cancer in Taiwan显示文摘OBJECTIVE: To examine and describe the use of Western and Chinese Medicine for pregnancy preparation among women with breast cancer after cancer-related treatment in Taiwan.METHODS: Women of reproductive age(20-49years) women who were treated for breast cancer from January 2011 through June 2015 in a Taiwan Residents city participated in the study. Of 306 eligible study participants, interviews were completed in197(64%). Participants were asked about sociodemographic variables, disease and treatment characteristics, their desire for fertility, and their use of Western or Chinese Medicine.RESULTS: The proportions of women who planned to use Western or Chinese Medicine to help achieve pregnancy were 17.3% and 14.7%, respectively. The result of binary logistic regression showed that current employment and lack of children were factors predictive of the use of Western Medicine. Younger age and the use of Chinese Medicine before treatment were predictors of using Chinese Medicine. While the desire for fertility preservation was related to the use of Western Medicine,the desire for pregnancy was related to the use of Chinese Medicine.CONCLUSION: Various characteristics guided the women's decisions to use Western or Chinese Medicine. Health care providers should learn patients' preferences for fertility preservation and provide appropriate advice, referring them to safe providers of their desired method of fertility treatment. | Ping-Ho Chen Sheng-Miauh Huang Jerry Cheng-Yen Lai Chen-Jei Tai Li-Yin Chien Yun-Hsiang Lee | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 2 |
| 9 | Research on performances of back-illuminated scientific CMOS for astronomical observations显示文摘To evaluate performances of a back-illuminated scientific CMOS(sCMOS)camera for astronomical observations,comparison tests between Andor Marana s CMOS and Andor iKon-L 936 CCD cameras were conducted in a laboratory and on a telescope.The laboratory tests showed that the readout noise of the sCMOS camera is about half lower,the dark current is about 17 times higher,the dynamic range is lower in the 12-bit setting and higher in the 16-bit setting,and the linearity and bias stability are comparable relative to those of the CCD camera.In field tests,we observed the open cluster M67 with the sCMOS and CCD cameras on a 60 cm telescope.Unlike the CCD camera,the sCMOS camera has a dual-amplifier architecture.Since a 16-bit image of the sCMOS camera is composed of two 12-bit images sampled with 12-bit high gain and low gain amplifiers simultaneously,it is not real 16-bit output data.The evaluation tests indicated that the dual-amplifier architecture of the s CMOS camera leads to a decline of photometric stability by about six times around specific pixel counts.For photometry of bright objects with similar magnitudes that require high frame rates,the s CMOS camera under 12-bit setting is a good choice.Therefore,the sCMOS camera is fitted with survey observations of variable objects requiring short exposure times,mostly less than 1 s,and high frame rates.It also satisfies the requirements for an offset guiding instrument owing to its high sensitivity,high temporal resolution and high stability. | Peng Qiu Yong Zhao Jie Zheng Jian-Feng Wang Xiao-Jun Jiang | 2021 | Research in Astronomy and Astrophysics2021，21，10： | 2 |
| 10 | Two-Step Coronal Transport of Solar Flare Particles from Magnetic Multipolarity Sources in a Flare Region显示文摘The transport of solar flare particles in the corona is studied.Considering the problems in terms of the characteristics of a sunspot group producing solar cosmic rays and solar flare processes,we find that formation of the fast propagation process is associated with annihilation of sunspots in the group with magnetic multipolarity.The slower propagation process depends on magnetic irregularities in the corona,and the evolution of the transport is related to the flare processes.Equations for the coronal transport are proposed and their initial and boundary conditions are given.The predicted results agree with the main observational features. | 黄永年 王世金 | 2001 | Chinese Physics Letters2001，18，2： | 2 |
| 11 | International normalized ratio and Model for End-stage Liver Disease score predict short-term outcome in cirrhotic patients after the resolution of hepatic encephalopathy显示文摘BACKGROUND In patients with cirrhosis,hepatic encephalopathy(HE)indicates a poor prognosis despite the use of artificial liver and liver transplantation,presenting as frequent hospitalizations and increased mortality rate.AIM To determine predictors of early readmission and mid-term mortality in cirrhotic patients discharged after the resolution of HE.METHODS From January to February 2018,213 patients were enrolled in this observational study assessing all the successive patients with cirrhosis discharged from Department of Gastroenterology and Department of Infectious and Liver Diseases,Second Affiliated Hospital of Chongqing Medical University after the resolution of HE.The patients were followed for 6 mo.For each subject,demographic,clinical,and laboratory variables were assessed at the time of diagnosis of HE,during hospital stay,at discharge,and during follow-up.The primary endpoints were incidence of early readmission and mid-term mortality.RESULTS During follow-up,65(31%)patients experienced an early readmission.International normalized ratio(INR)[odds ratio(OR)=2.40;P=0.003)at discharge independently predicted early readmission.The incidence of early readmission was significantly higher in patients with an INR>1.62 at discharge than in those with an INR≤1.62(44%vs 19%;P<0.001).Model for End-stage Liver Disease(MELD)score(OR=1.11;P=0.048)at discharge proved to be an independent predictor of early readmission caused by HE.Hemoglobin(OR=0.97;P=0.005)at discharge proved to be an independent predictor of non-early readmission.During 6 months of follow-up,34(16%)patients died.Artificial liver use(hazard ratio=6.67;P=0.021)during the first hospitalization independently predicted mid-term mortality.CONCLUSION INR could be applied to identify fragile cirrhotic patients,MELD score could be used to predict early relapse of HE,and anemia is a potential target for preventing early readmission. | Xiao-Peng Hu Jian Gao | 2019 | World Journal of Gastroenterology2019，25，26： | 2 |
| 12 | Ultra-low noise L-band cryogenic astronomical receiver for the FAST telescope显示文摘This paper presents an ultra-low noise L-band radio astronomical cryogenic receiver for the Fivehundred-meter Aperture Spherical radio Telescope(FAST) telescope. The development of key low noise microwave parts of coupling low noise amplifier(Coupling-LNA) and conical quad-ridge orthogonal mode transducers(OMT) and reasonable system integration achieve outstanding performance of receiver. It covers the frequency range of 1.2 GHz to 1.8 GHz. Novel cryogenic Coupling-LNAs with low noise, large return loss, high dynamic range and the function of coupling calibration signals are developed for the proposed receiver. Amplification and coupling function circuits are integrated as a single Coupling-LNA with full noise temperature of 4 K at the physical temperature of 15 K. Its return loss is more than 18 d B, and output1 d B compression power is +5 d Bm. A cryogenic dewar is fabricated to provide 55 K and 15 K cryogenic environment for OMT and Coupling-LNAs, respectively. The receiver's system noise temperature is below9 K referred to feed aperture plane. Benefiting from optimal design and precise mechanical treatment, good scattering performance of OMT and equalized radiation patterns of horn are achieved with an antenna efficiency above 75%. | 刘鸿飞 何川 王进 姜鹏 王生旺 伍洋 张航 宋金友 石向玮 郭明雷 | 2021 | Research in Astronomy and Astrophysics2021，21，7： | 2 |
| 13 | The Mathematic Models of the Kalman Filtering for Across-Fault Measurement显示文摘This paper makes a probe into the application of the Kalman filtering method to the data processing of across-fault measurements.On the basis of statistical regression,the mathematic and stochastic models of filtration are established by combining the regression method with Kalman filtering.In the filtering computation,not only the randomness of fault movements but also the time-dependent variation of environmental effects have been taken into consideration.By use of the adaptive filtering method,an estimation of the dynamic noise variance matrix is obtained through iteration.Models for one measuring line(leveling line or baseline),two measuring lines(both leveling lines or both baselines)and four measuring lines(two leveling lines and two baselines)are derived and established systematically.By means of these models,the data of across-fault measurements can be processed dynamically in real-time to provide the filtered values of height difference between benchmarks or baseline length at different time | You Lilan,Liu Dajie,Huang Jia’na,Liu Xue and Zhou KechangInstitute of Crustat Dynamics,SSB,Beijing 100085,China Wuhan Technical University of Surveying and Mapping,Wuhan 430070,China National Center for Seismic Data and Inforraanon,SSB,Beijing 100045,China | 1994 | Earthquake Research in China1994，8，3： | 1 |
| 14 | A new sequential data assimilation method显示文摘A new sequential data assimilation method named 'Monte Carlo H ∞ filter' is introduced based on H ∞ filter technique and Monte Carlo method in this paper. This method applies to nonlinear systems in condition of lacking the statistical properties of observational errors. In order to compare the as- similation capability of Monte Carlo H ∞ filter with that of the ensemble Kalman filter (EnKF) in solving practical problems caused by temporal correlation or spatial correlation of observational errors, two numerical experiments are performed by using Lorenz (1963) system and shallow-water equations re- spectively. The result is that the assimilation capability of the new method is better than that of EnKF method. It is also shown that Monte Carlo H ∞ filter assimilation method is effective and suitable to nonlinear systems in that it does not depend on the statistical properties of observational errors and has better robustness than EnKF method when the statistical properties of observational errors are varying. In addition, for the new method, the smallest level factor founded by search method is flow-dependent. | HAN YueQi ZHANG YaoCun WANG YunFeng YE Song FANG HanXian | 2009 | Science China(Technological Sciences)2009，52，4： | 1 |
| 15 | THERMAL STATE OF THE TANGGULA REGION显示文摘In a previous article, we have reported some results of our study of the radiation in the Tanggula region; and in the present one, we are presenting some results of our study of the thermal state of the region.In our study of the thermal state we used the same observation stations we had used in our observation of radiation and the time was also the same. The | 陆龙骅 戴加洗 | 1980 | Chinese Science Bulletin1980，25，6： | 1 |
| 16 | Significance of the neutrophil-lymphocyte ratio in elderly type 2 diabetic patients with coronary heart disease显示文摘Objective To evaluate the value of the neutrophillymphocyte ratio(NLR)in elderly type 2 diabetic patients(T2DM)with coronary heart disease(CHD).Methods We performed a retrospective observational study on 228 patients undergoing coronary angiography | Dept Endocrinol,Guizhou Prov People’s Hosp | 2016 | China Medical Abstracts(Internal Medicine)2016，33，2： | 1 |
| 17 | Constraints on brane inflation after Planck 2015: Impacts of the latest local measurement of the Hubble constant显示文摘We investigate the observational constraints on three typical brane inflation models by considering the latest local measurement of the Hubble constant in the global fit. We also employ other observational data, including the Planck 2015 CMB data, the BICEP2/Keck Array B-mode data, and the baryon acoustic oscillations data, in our analysis. Previous studies have shown that the addition of the latest local H_0 measurement favors a larger spectral index, and can exert a significant influence on the model selection of inflation. In this work, we investigate its impacts on the status of brane inflation models. We find that, when the direct H_0 measurement is considered, the prototype model of brane inflation is still in good agreement with the current observational data within the 2σ level range. For the KKLMMT model, the consideration of the H_0 measurement allows the range of the parameter β to be amplified to O(10^(-2)), which slightly alleviates the fine-tuning problem. For the IR DBI model, the addition of the H_0 measurement does not provide a better fit. These results show that the consideration of the new H_0 prior can exert a considerable influence on the brane inflation models. At last, we show that, when β≤1.1, the equilateral non-Gaussianity in the IR DBI inflation model is compatible with the current CMB data at the 1σ level. | Rui-Yun Guo Lei Zhang Jing-Fei Zhang Xin Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 1 |
| 18 | SIGNIFICANCE TESTS FOR THE SECULAR POLAR MOTION DURING THE YEARS 1949—1976显示文摘When secular polar motion and variation of latitude are expressed as: | 李正心 | 1982 | Chinese Science Bulletin1982，27，9： | 1 |
| 19 | Climatological analysis of the seeing at Fuxian Solar Observatory显示文摘There is a significant seasonal variation in the seeing of Fuxian Solar Observatory(FSO). The seeing in summer and autumn is better than that in winter and spring. The overall seeing is divided into the boundary layer seeing and free atmosphere seeing to investigate the climatic phenomena or meteorological events that might lead to seasonal variation in the seeing. The overall seeing was measured by the solar difference image motion monitor(SDIMM). The boundary layer seeing is calculated from the temperature difference between air and water. The analysis results show that the seasonal variation in seeing is caused by the alternation of subtropical high and westerly jet. The decrease of seeing in winter and spring at FSO is probably related to the westerly jet. A complete analysis of the seeing at FSO is given in this paper. It is also the first time to describe FSO's boundary layer seeing and its measurement method. | Li-Hui Chen Zhong Liu Dong Chen | 2019 | Research in Astronomy and Astrophysics2019，19，1： | 1 |
| 20 | Relationship between the Interannual Variations of Total Ozone in the Northern Hemisphere and the QBO of Basic Flow in the Tropical Stratosphere显示文摘The harmonic analyses of monthly mean total ozone in the atmosphere over the Northern Hemisphere for 26 years (1960-1985) are made by using the Fourier expansion. The analysed results show that there is obviously a quasi-biennial oscillation (QBO) in the interannual variations of the amplitudes of total ozone. Generally, the amplitudes of wavenumber 1 and 2 during the westerly of the equatorial QBO are larger than those during the easterly. In the early winter, the amplitude of wavenumber 1 during the easterly phase is larger, and in the late winter, it is larger during the westerly phase. These are in good agreement with the observational distributions. | 黄荣辉 王连英 | 1990 | Advances in Atmospheric Sciences1990，7，1： | 0 |
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