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| 1 | 大鼠骨髓来源的c-met^+β_2m^-细胞向肝细胞样细胞诱导分化的实验研究显示文摘为了观察大鼠骨髓来源的c-met+β2m-细胞在体内外是否可定向诱导分化为肝细胞样细胞,将雄性F344大鼠的c-met+β2m-细胞通过肝门静脉移植入由丙烯醇诱导损伤的F344雌鼠体内,观察移植细胞在受鼠肝内整合、增殖、分化、成熟以及损伤后的修复作用;通过模拟丙烯醇肝损伤大鼠体内微环境,将c-met+β2m-细胞与损伤肝细胞共培养,观察了c-met+β2m-细胞的形态变化,并检测了肝细胞特异性蛋白的表达和肝细胞特异性功能的变化.结果表明,大鼠 c-met+β2m-细胞在体内外均可以分化为成熟的有功能的肝细胞,提示微环境在成体干细胞定向诱导分化中起决定性作用,这为骨髓成体干细胞移植治疗各种原因引发的肝功能障碍提供了新的途径. | 南雪 王韫芳 尉承泽 梁峰 张锐 岳慧敏 岳文 裴雪涛 | 2006 | 自然科学进展2006，16，1： | 3 |
| 2 | Differentiation of human embryonic stem cells along a hepatocyte lineage and its application in liver regeneration显示文摘Hepatocyte transplantation and bioartificial liver (BAL) as alternatives to liver transplantation offer the possibility of effective treatment for many inherited and acquired hepatic disorders. Unfortunately, the limited availability of donated livers and the variability of their derived hepatocytes make it difficult to obtain enough viable human hepatocytes for the hepatocyte-based therapies. Embryonic stem cells (ESCs), which could be isolated directly from the blastocyst inner cell mass, have permanent self-renewal capability and developmental pluripotency and therefore might be an ideal cell source in the treatment of hepatic discords. However, differentiation of hESCs into hepatocytes with significant numbers remains a challenge. This review updates our current understanding of differentiation of ESCs into hepatic lineage cells, their future therapeutic uses and problems in liver regeneration. | PEI HaiYun WANG YunFang PEI XueTao | 2008 | Chinese Science Bulletin2008，53，1： | 2 |
| 3 | Therapeutic applications of bone marrow-derived stem cells in liver transplantation for end-stage liver diseases显示文摘Today, liver transplantation (LT) is the only established treatment for end-stage liver diseases. The de- velopment of LT, including OLT, cadaveric LT, split LT, living donor LT (LDLT), brings hopes to patients with these diseases. However, increasing donor shortage, rejection and life-long immunosuppression with its side effects are the major limitations of this therapy strategy. Bone marrow-derived stem cells (BMDSCs) are capable of differentiating into hepatocyte-like cells and contribute to liver injury repair. The microenvironment of liver injury caused by rejection, ischemia/reperfusion, loss of liver mass, recurrence of HCV and 'small-for-size syndrome' after LT can attract a variety of bone marrow-derived stem cell population to the peripheral circulation and then migration to the injury liver to promote the hepatic function restoration. Additionally, BMDSCs can also take part in the functional regeneration of living donor liver after LDLT. This participation in liver regeneration may be associated to the interac- tion between SDF-1and its receptor CXCR4, involving HGF, IL-8, MMP9, and VEGF/VEGFR-2. BMDSC with its bio-characteristics could maintain the allograft tolerance from different angles and in different ways. In conclusion, BMDSCs transplantation, as a new assistant therapeutic method for LT, will ex- pand the space of LT, and provide more survival opportunities for the patients suffering liver diseases in the future. | LUO HaiYing WANG YunFang KONG Wei PEI XueTao | 2007 | Chinese Science Bulletin2007，52，18： | 0 |
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