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| 1 | Role of potassium in acid secretion显示文摘Potassium (K+) ions are critical for the activation and catalytic cycle of the gastric H+,K+-ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus. As both symptom, severity and esophageal mucosal damage in gastro-esophageal reflux disease (GERD) are related to the degree of acid exposure, K+ is a logical target for approaches to inhibit acid production.The probable K+ binding site on the gastric H+,K+-ATPase has recently been described and studies are elucidating how K+ activates the enzyme. K+ channels in the apical membrane of the parietal cell are implicated in the recycling of K+ and, to date, three potential K+ channels (KCNQ1, Kir2.1 and Kir4.1) have been identified. The channels represent theoretical sites for agents to control acid secretion but it will be difficult to develop selective blockers. An alternative strategy is to prevent K+ from activating gastric H+,K+-ATPase; the potassiumcompetitive acid blocker (P-CAB) class inhibits acidsecretion by binding at or near the K+ binding site.Ongoing research is further defining the role of K+ in the functioning of the gastric H+,K+-ATPase, as well as determining the clinical utility of agents directed toward this important cation. | John P Geibel | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | 质子泵抑制剂对心血管疾病发生风险的研究进展显示文摘质子泵抑制剂(PPIs)是有效的胃酸抑制剂,广泛用于胃酸相关性疾病。一般来说,PPIs的安全性好。但在PPIs的长期应用过程中,其安全性及药效受到了多方面的质疑。在心血管疾病治疗领域,PPIs和氯吡格雷之间的药物相互作用,使其联合运用在急性冠状动脉综合征患者中得到了特别的关注。目前,应用PPIs导致的心血管疾病高发人群可能已经从冠状动脉疾病患者中扩展到了普通人群。本文通过对普通人群的PPIs使用所发生心血管疾病的风险,及其潜在的生理机制进行综述,以期为临床治疗疾病提供新的思维。 | 黄冠东 仲伟喜 封启明 | 2018 | 海南医学2018，29，6： | 5 |
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