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| 1 | Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro显示文摘Purified avian infectious bronchitis virus (IBV) was used to screen a random phage dis-play peptide library. After the fourth panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells and blocked IBV haemagglutination. One linear peptide “GSH HRH VHS PFV” from the positive phages with the highest neutralization titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development of antiviral therapeutics for IBV and studying the determinants for viral and cell interac-tion. | PENG Bo1, CHEN Hanyang1, TAN Yadi1,2, JIN Meilin1,2, CHEN Huanchun1,2 & GUO Aizhen1,2 1. Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China 2. National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China | 2006 | Science China(Life Sciences)2006，49，2： | 3 |
| 2 | Genome sequence variationanalysis of two SARS coronavirus isolates afterpassage in Vero cell culture显示文摘SARS coronavirus is an RNA virus whose rep- lication is error-prone, which provides possibility for escape of host defenses, and even leads to evolution of new viral strains during the passage or the transmission. Lots of varia- tions have been detected among different SARS-CoV strains. And a study on these variations is helpful for development of efficient vaccine. Moreover, the test of nucleic acid characterization and genetic stability of SARS-CoV is im- portant in the research of inactivated vaccine. The whole genome sequences of two SARS coronavirus strains after passage in Vero cell culture were determined and were com- pared with those of early passages, respectively. Results showed that both SARS coronavirus strains have high ge- netic stability, although nearly 10 generations were passed. Four nucleotide variations were observed between the sec- ond passage and the 11th passage of Sino1 strain for identi- fication of SARS inactivated vaccine. Moreover, only one nucleotide was different between the third passage and the 10th passage of Sino3 strain for SARS inactivated vaccine. Therefore, this study suggested it was possible to develop inactivated vaccine against SARS-CoV in the future. | JINWeiwu HULiangxiang DUZhenglin GAOQiang GAOHong NINGYe FENGJidong ZHANGJiansan YINWeidong LINing | 2004 | Chinese Science Bulletin2004，49，17： | 1 |
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