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| 1 | 基于模板技术的生物信息软件Web自动发布系统显示文摘随着人类基因组计划的完成,涌现了大量旨在从生物数据中分析和挖掘有关知识的生物信息软件,对这些软件进行Web发布以提供共享服务也就变得日益重要。采用B/S模式、模板技术以及Java相关技术,设计和实现了一个生物信息软件Web自动发布系统(简称BSWAP),它能方便地将本地软件发布到Internet,提供软件的在线计算、实时下载等服务。该系统已应用于人类遗传基因信息数据整合及共享信息平台(简称HGRP)。 | 何莹 唐九飞 | 2007 | 计算机工程与设计2007，28，17： | 2 |
| 2 | Glia Maturation Factor Gamma (GMFG): A Cytokine-Responsive Protein During Hematopoietic Lineage Development and Its Func-tional Genomics Analysis显示文摘Human hematopoiesis was evaluated using the techniques of controlled stem cell differentiation, two-dimensional gel electrophoresis-based proteomics, and functional genomics. We provide the first report that glia maturation factor gamma (GMFG) is a cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimulating factor-induced hematopoietic lineage development. Results from global functional genomics analysis indicate that GMFG possesses several other features: hematopoietic tissue-specific gene expression, a promoter concentrated with high-score hematopoiesis-specific transcription factors, and pos- sible molecular coevolution with a rudimentary blood/immune system. On the basis of our findings, we hypothesize that GMFG is a hematopoietic-specific pro- tein that may mediate the pluripotentiality and lineage commitment of human hematopoietic stem cells. | Ying Shi Ling Chen Lance A. Liotta Hong-Hui Wan Griffin P. Rodgers | 2006 | Genomics, Proteomics & Bioinformatics2006，4，3： | 2 |
| 3 | 基于功能的疾病基因预测系统设计与应用显示文摘针对与某种特定器官组织相关的疾病,利用新基因识别、基因功能预测以及疾病基因预测等技术,提出并实现一个基于基因功能信息的疾病候选基因预测系统。将其用于心血管疾病相关基因的大规模分析与预测,结果证明,该系统可以对疾病候选区间的已知基因进行致病可能性的鉴别,发现新基因,并判定新基因与疾病的相关程度。 | 袁芳 王瑞春 管明祥 周艳红 | 2010 | 计算机工程2010，36，12： | 2 |
| 4 | 水稻基因结构分析与预测建模显示文摘将水稻基因结构预测问题划分为基因级、元件级和特征级等多个层次上的一系列较简单子问题,分析了各特征与序列C+G含量之间的依赖关系,通过采用从简单到复杂逐级优化的策略建立了不同序列C+G含量的水稻基因结构模型,设计了基因结构寻优的动态规划算法,开发了水稻基因结构预测软件Rice-GenePRE.采用测试数据集OsSNG550对该软件进行测试的结果显示:RiceGenePRE在核苷酸、外显子和基因水平上的预测效果均优于水稻基因结构预测系统FGENESH. | 周艳红 朱建丽 马闯 程遥 | 2008 | 华中科技大学学报(自然科学版)2008，36，4： | 0 |
| 5 | Identification of true EST alignments and exon regions of gene sequences显示文摘Expressed sequence tags (ESTs), which have piled up considerably so far, provide a valuable resource for finding new genes, disease-relevant genes, and for recogniz- ing alternative splicing variants, SNP sites, etc. The prereq- uisite for carrying out these researches is to correctly ascer- tain the gene-sequence-related ESTs. Based on analysis of the alignment results between some known gene sequences and ESTs in public database, several measures including Identity Check, Gap Check, Inclusion Check and Length Check have been introduced to judge whether an EST alignment is re- lated to a gene sequence or not. A computational program EDSAc1.0 has been developed to identify true EST align- ments and exon regions of query gene sequences. When tested with human gene sequences in the standard dataset HMR195 and evaluated with the standard measures of gene prediction performance, EDSAc1.0 can identify protein- coding regions with specificity of 0.997 and sensitivity of 0.88 at the nucleotide level, which outperform that of the coun- terpart TAP. A web server of EDSAc1.0 is available at http://gffzz1e27d934a2c544d2hq9fqqu95u9qw6p0b.ffgz.tsg.suse.edu.cn. | ZHOUYanhong JINGHui LIYanen LIUHuailan | 2004 | Chinese Science Bulletin2004，49，23： | 0 |
| 6 | Predicting disease genes for familial dilated cardiomyopathy based on the codon usage bias显示文摘Familial dilated cardiomyopathy (FDC) is a common monogenic disease mostly with autosomal dominant inheritance. Fifteen different loci for autosomal dominant FDC have been mapped; however, only eight FDC genes have been found, and it is still a big challenge to identify ad-ditional seven FDC genes in their chromosomal regions. We found that the codon usage frequencies in most of known FDC gene sequences are consistently biased, and significantly different from the average codon usage frequencies of human genes. This unique feature of codon usage was used to de-velop a novel approach to predicting FDC genes. Leave-one- out cross-validation results demonstrate that this approach can effectively detect FDC genes from numbers of genes in their chromosomal regions. Another advantage of this ap-proach is that it is solely based on DNA sequences and there-fore has the ability to identify potential FDC genes whose functions are completely unknown. Further, this approach has been used to analyze the seven FDC loci in which the FDC genes are still unknown. Both the detailed prediction results and the prediction program are available at http:// infosci.hust.edu.cn, which might provide help for relevant experimental researches to find new FDC genes. | ZHOU Yanhong ZHOU Quanxiong LIU Huailan WAN Honghui | 2005 | Chinese Science Bulletin2005，50，18： | 0 |
| 7 | 基于特征融合的选择性剪切外显子预测显示文摘基因在转录的过程中,mRNA前体常常会经过一个选择性剪切的过程,它包括多种选择性剪切形式。选择性剪切的鉴别在生命科学的研究和医学上都有重要意义。由于选择性剪切的内在限制,同类的预测选择性剪切的模型或者算法只能预测出特殊的选择性剪切事件的类别。本文在研究序列本身特征的基础上,考虑了碱基的保守性,并结合支持向量机建立的预测模型对选择性剪切外显子进行预测。性能测试结果显示,相比同类预测模型该方法在性能方面有了一定提高。 | 袁芳 范金坪 | 2014 | 计算机与数字工程2014，42，11： | 0 |
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