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| 1 | Eosinophilic gastroenteritis:An unusual type of gastroenteritis显示文摘Eosinophilic gastroenteritis(EGE) is a rare disorder characterized by eosinophilic infiltration of the bowel wall with various gastrointestinal manifestations.Till date only 280 cases have been described in the literature.A high index of suspicion,by excluding other causes of peripheral eosinophilia,is a pre requisite for accurate diagnosis.EGE is an uncommon gastrointestinal disease affecting both children and adults.It was first described by Kaijser in 1937.Presentation may vary depending on location as well as depth and extent of bowel wall involvement and usually runs a chronic relapsing course.This condition can respond to low dose steroid therapy,thereby preventing grave complications like ascites and intestinal obstruction that might need surgical intervention.The natural history of EGE has not been well documented.Eosinophilic gastroenteritis is a chronic,waxing and waning condition.Mild and sporadic symptoms can be managed with reassurance and observation,whereas disabling gastrointestinal(GI) symptom flare-ups can often be controlled with oral corticosteroids.When the disease manifests in infancy and specific food sensitization can be identified,the likelihood of disease remission by late childhood is high.GI obstruction is the most common complication.Fatal outcomes are rare. | Sachin B Ingle Chitra R Hinge(Ingle) | 2013 | World Journal of Gastroenterology2013，19，31： | 47 |
| 2 | Unusual presentations of eosinophilic gastroenteritis:Case series and review of literature显示文摘Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy. | Rafiq A Sheikh Thomas P Prindiville R Erick Pecha Boris H Ruebner | 2009 | World Journal of Gastroenterology2009，15，17： | 43 |
| 3 | 20例嗜酸性粒细胞性胃肠炎临床及内镜特点分析显示文摘目的探讨嗜酸性粒细胞性胃肠炎(EG)患者的临床表现及内镜检查对该病的诊治价值。方法对20例EG患者的临床特点、试验室检查、内镜表现和治疗随诊情况进行分析。结果20例患者中黏膜型12例、浆膜型2例、混合型6例;EG临床表现以腹痛为主,可伴有腹胀、腹泻、腹水、恶心、呕吐;外周血和骨髓中嗜酸性粒细胞计数明显增多(13.5%-50.6%和7.8%-38.5%),腹水中可见大量嗜酸性粒细胞;内镜表现为黏膜充血水肿、糜烂,病理检查可见大量嗜酸性粒细胞浸润;糖皮质激素治疗1-2周内可迅速缓解症状,减量维持,然后逐渐减量至停药;病情可反复,但预后良好。结论EG患者临床和内镜表现无特异性,外周血和腹水中嗜酸性粒细胞计数明显增多,胃肠黏膜组织中嗜酸性粒细胞浸润是诊断的关键,糖皮质激素治疗效果良好。 | 黄焕军 刘瑶 刘南植 田德安 | 2008 | 临床内科杂志2008，25，6： | 29 |
| 4 | Endoscopic findings in a patient with Henoch-Schonlein purpura显示文摘Hcnoch Schoenlein purpura (HSP) is a systemic vasculitis of the small vessels of the skin,joints,GI tract, and kidney.It preferentially affects children but may also occur in adults.We report a 60-rear-old man with HSP who presented with colicky abdominal pain,blondy diarrhea,arthralgia,and skin rash.The gastrointestinal tract was viewed by upper endoscopy and colonoscopy.We found characterislic endoscopic findings in the stomach,cecum and sigmoid colon,the combination of which has rarely been demonstrated in one patient.Histologic examination of skin biopsy specimens revealed leukocytoclastic vasculitis with positive staining for IgA in the capillaries.Endoscopy appears to have substantial diagnostic utility in patients suspected of having HSP,especially when abdominal symptoms precede the cutaneous lesions. | Ming-Jen Chen Tsang-En Wang Wen-Hsiung Chang Shu-Jung Tsai | 2005 | World Journal of Gastroenterology2005，11，15： | 24 |
| 5 | Eosinophilic gastroenteritis:Approach to diagnosis and management显示文摘Eosinophilic gastroenteritis(EGE) is a rare and benign inflammatory disorder that predominantly affects the stomach and the small intestine.The disease is divided into three subtypes(mucosal,muscular and serosal) according to klein's classification,and its manifestations are protean,depending on the involved intestinal seg-ments and layers.Hence,accurate diagnosis of EGE poses a significant challenge to clinicians,with evidence of the following three criteria required:Suspicious clinical symptoms,histologic evidence of eosinophilic infiltration in the bowel and exclusion of other pathologies with similar findings.In this review,we designed and applied an algorithm to clarify the steps to follow for diagnosis of EGE in clinical practice.The management of EGE represents another area of debate.Prednisone remains the mainstay of treatment;however the disease is recognized as a chronic disorder and one that most frequently follows a relapsing course that requires maintenance therapy.Since prolonged steroid treatment carries of risk of serious adverse effects,other options with better safety profiles have been proposed;these include budesonide,dietary restrictions and steroid-sparing agents,such as leukotriene inhibitors,azathioprine,anti-histamines and mast-cell stabilizers.Single cases or small case series have been reported in the literature for all of these options,and we provide in this review a summary of these various therapeutic modalities,placing them within the context of our novel algorithm for EGE management according to disease severity upon presentation. | Antoine Abou Rached Weam El Hajj | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 24 |
| 6 | Eosinophilic ascites,an unusual presentation of eosinophilic gastroenteritis:A case report and review显示文摘Eosinophilic ascites(EA)is a rare disorder of unknown etiology that has been reported in both adult and pediatric patients.It is a part of the syndrome of eosinophilic gastroenteritis,which is characterized by eosinophilic infiltration of any or all layers of the gut wall and may involve any segment of the gastrointestinal tract.Peripheral eosinophilia may or may not be present.We report a case of EA that developed post partum. | Iryna S Hepburn Subbaramiah Sridhar Robert R Schade | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 22 |
| 7 | 嗜酸细胞性胃肠炎临床分析显示文摘背景:嗜酸细胞性胃肠炎(EG)是一种少见的良性消化道疾病,临床表现无特异性,误诊率较高。目的:通过对EG的一般情况、发病诱因、临床表现、辅助检查、诊断分型、误诊情况以及治疗和预后进行分析,以提高对该病的认识,避免误诊误治,减少患者痛苦。方法:对中国人民解放军总医院消化疾病中心的4例EG以及以'嗜酸细胞,胃肠炎'为关键词在中国医院知识仓库医学专题全文数据库(CHKD)中检索得到的1997~2007年发表的文献中169例EG的临床特点进行分析。结果:本组资料显示,44.5%的EG与过敏有关,常见临床表现为腹痛(94.2%)、腹泻(60.7%)、恶心(56.1%)、呕吐(51.5%)、腹胀(38.2%)、腹水(28.3%)。嗜酸性粒细胞(EOS)升高在外周血、骨髓和腹水中的阳性率分别为74.0%、98.2%和90.3%。胃镜和结肠镜黏膜活检发现EOS浸润胃黏膜和肠黏膜分别占88.2%和64.6%。诊断以黏膜型EG最为多见(65.3%),误诊率为40.5%。77.5%的EG患者接受糖皮质激素治疗,疗效良好。结论:EG是一种易误诊的少见病,临床表现无特异性,确诊应从提高对该病的认识、适时行血常规、骨髓和腹水EOS检查、胃肠道黏膜活检病理检查等方面入手。糖皮质激素治疗EG有效,预后良好。 | 聂艳孝 侯鹏 杨云生 吴志强 殷健 汪涛 郭旭 | 2008 | 胃肠病学2008，13，5： | 23 |
| 8 | 嗜酸粒细胞性胃肠炎临床分析24例显示文摘目的:分析嗜酸粒细胞性胃肠炎的临床特点、诊断要点、治疗及预后.方法:对本院确诊的24例嗜酸粒细胞性胃肠炎患者的病史、临床表现、实验室检查、内镜检查、病理检查、治疗及随访情况进行系统分析.结果:本组资料显示,有过敏史者占37.5%,过敏诱因者占25%.腹痛(87.5%)为最常见的临床表现.83.3%患者外周血嗜酸粒细胞计数升高,为(4.59±3.69)×109/L.内镜下主要表现为黏膜充血水肿、糜烂,以十二指肠最为明显,活检可证实大量嗜酸粒细胞浸润.腹水为渗出液,可见嗜酸粒细胞.激素治疗可在lwk内迅速缓解症状,并使嗜酸粒细胞恢复正常.病情可有反复,但预后良好.结论:外周血嗜酸粒细胞计数、过敏史对诊断嗜酸粒细胞性胃肠炎有提示作用,内镜下黏膜活检和腹水嗜酸粒细胞增多是诊断的关键.糖皮质激素治疗优于饮食治疗,预后良好. | 李静 王邦茂 张洁 姜葵 方维丽 程静 沈阳 苏帅 | 2009 | 世界华人消化杂志2009，17，36： | 21 |
| 9 | Eosinophilic gastroenteritis presenting as small bowel obstruction: A case report and review of the literature显示文摘Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract. Recently, the authors experienced a case of eosinophilic gastroenteritis presenting as small bowel obstruction. A 51-year old woman was admitted to our hospital complaining of abdominal pain and vomiting. Physical examination revealed a distended abdomen with diffuse tenderness. Complete blood count showed mild leukocytosis without eosinophilia. Computed tomography confirmed a dilatation of the small intestine with ascites. An emergency laparotomy was performed for a diagnosis of peritonitis due to intestinal obstruction. Segmental resection of the ileum and end to end anastomosis were performed. Histologically, there was a dense infiltration of eosinophils throughout the entire thickness of ileal wall and eosinophilic enteritis was diagnosed. The patient recovered well, and was free from gastrointestinal symptoms at the time when we reported her disease. | Min Young Yun Young Up Cho In Suh Park Sun Keun Choi Sei Joong Kim Seok Hwan Shin Kyung Rae Kim | 2007 | World Journal of Gastroenterology2007，13，11： | 19 |
| 10 | Fecal microbiota transplantation and prednisone for severe eosinophilic gastroenteritis显示文摘Eosinophilic gastroenteritis is a rare disease of unknown etiology.It is characterized by patchy or diffuse eosinophilic infiltration of the bowel wall to a variable depth and various gastrointestinal manifestations.We describe a case of severe eosinophilic gastroenteritis presenting as frequent bowel obstruction and diarrhea in a 35-year-old man.The patient was misdiagnosed and underwent surgery because of intestinal obstruction when he was first admitted to a local hospital.Then he was misdiagnosed as having Crohn’s disease in another university teaching hospital.Finally,the patient asked for further treatment from our hospital because of the on-going clinical trial for treating refractory Crohn’s disease by fecal microbiota transplantation.Physical examination revealed a slight distended abdomen with diffuse tenderness.Laboratory investigation showed the total number of normal leukocytes with neutrophilia as 90.5%,as well as eosinopenia,monocytopenia and lymphocytopenia.Barium radiography and sigmoidoscopy confirmed inflammatory stenosis of the sigmoid colon.We diagnosed the patient as having eosinophilic gastroenteritis by multi-examinations.The patient was treated by fecal microbiota transplantation combined with oral prednisone,and was free from gastrointestinal symptoms at the time when we reported his disease.This case highlights the importance of awareness of manifestations of a rare disease like eosinophilic gastroenteritis. | Yi-Xuan Dai Chuan-Bing Shi Bo-Ta Cui Min Wang Guo-Zhong Ji Fa-Ming Zhang | 2014 | World Journal of Gastroenterology2014，20，43： | 18 |
| 11 | 儿童嗜酸性粒细胞性胃肠炎的诊断与治疗进展显示文摘嗜酸性粒细胞性胃肠炎(EGE)是一种儿童相对少见的良性慢性胃肠道炎性疾病,以胃肠道嗜酸性粒细胞(EOS)浸润为特征,临床表现因浸润部位及层次不同而呈多样性,内镜下表现无特异性,EGE的确诊主要依据消化道症状、大量EOS组织学浸润,以及除外引起胃肠道组织EOS浸润的其他疾病。治疗包括膳食疗法、糖皮质激素、抗过敏药物、免疫调节疗法等。尽管膳食疗法和糖皮质激素治疗可改善大多数患儿的临床症状,但常需要长期地维持治疗和随访,以防止复发。出现并发症者,如狭窄、穿孔、梗阻等,则需要外科干预。 | 徐樨巍 李东丹 | 2018 | 中华实用儿科临床杂志2018，33，7： | 14 |
| 12 | 小儿嗜酸细胞性胃肠炎的临床研究进展显示文摘小儿嗜酸细胞 (EC)性胃肠炎是一种比较少见的胃肠道疾病。发病机制不甚明确 ,可能是对外源性或内源性过敏原的全身或局部变态反应所致。以EC浸润从食管到直肠的全胃肠道壁的黏膜层、黏膜下层、肌层甚至浆膜层为典型特点。EC浸润的范围和深度决定了该病临床表现的多样化。诊断的金标准取决于内镜活检、腹水找EC、腹腔镜检查、外科手术活检。治疗主要有饮食治疗、激素治疗及其他药物治疗。近年来 ,随着内镜技术在儿科临床的广泛应用 ,对该病的认识及诊治提出了许多新观点 。 | 李在玲 | 2004 | 国外医学(儿科学分册)2004，31，3： | 11 |
| 13 | 嗜酸细胞性胃肠炎16例临床分析显示文摘目的:探讨嗜酸细胞性胃肠炎(eosinophilicgastroenteritis,EG)临床特点和治疗。方法:检索我院1997-2005年共收治的16例EG患者,对他们的临床特点、实验室检查、内镜表现和治疗随访情况进行系统分析。结果:(1)EG患者的临床表现多样,包括腹痛、腹泻、腹胀、恶心、呕吐、低热及体重下降等,其主要取决于病变累及的范围和程度。(2)外周血和骨髓中嗜酸细胞计数随着症状的缓解而下降。(3)内镜下表现多为黏膜糜烂和水肿,缺乏特异性,以胃窦和回盲部最常受累,活检可见大量嗜酸细胞浸润。(4)激素为治疗EG的一线药物,可迅速缓解症状,并使嗜酸细胞恢复正常。(5)病情可反复,反复复发的患者可考虑延长激素的治疗时间或应用免疫抑制剂。结论:EG在诊断上极易造成误诊,最后的诊断需要依靠活组织检查来证实。 | 曹珊 王晶桐 | 2007 | 实用医学杂志2007，23，1： | 9 |
| 14 | 嗜酸性粒细胞性胃肠炎临床特点分析显示文摘目的探讨嗜酸性粒细胞性胃肠炎(EG)的临床特征。方法对21例EG患者的临床资料进行回顾性分析。结果 21例EG患者中,最常见的临床症状为腹痛(76.2%),以及恶心呕吐、腹胀、腹泻、纳差等。20例外周血嗜酸性粒细胞增高(95.2%),内镜检查见炎症最常累及胃窦及十二指肠球部,组织活检可见嗜酸性粒细胞浸润。黏膜型13例,混合型(黏膜型合并浆膜型)8例。腹腔积液阳性者(7例),混合型所占比例、合并电解质紊乱例数及CRP水平均高于腹腔积液阴性者(14例)。21例确诊后均予饮食调节和去除过敏原治疗,同时给予抑酸、保护胃黏膜、调节胃肠动力和肠道菌群等药物,其中15例予泼尼松治疗。治疗后患者嗜酸性粒细胞计数低于治疗前,症状得到改善。结论 EG临床表现无特异性,超敏反应病史、外周血嗜酸性粒细胞计数增高、胃肠道组织嗜酸性粒细胞浸润有助于诊断,确诊依靠组织活检。合并腹腔积液者较无腹腔积液者病情重。治疗主要是去除过敏原及对症治疗,对于症状较重者可加用糖皮质激素。 | 牛薇 弓艳霞 唐艳萍 | 2014 | 山东医药2014，54，2： | 9 |
| 15 | 嗜酸性粒细胞性胃肠炎24例临床分析显示文摘背景:嗜酸性粒细胞性胃肠炎(EGE)是一种少见的胃肠道疾病,以胃肠壁内嗜酸性粒细胞(EOS)浸润为特征。迄今为止,国内外对于EGE的认识主要源于个案报道和一些小型病例分析。目的:分析EGE的临床、内镜、组织病理学特点以及治疗和复发情况。方法:对2008年11月—2018年6月西京消化病医院收治的24例EGE患者进行回顾性分析。结果:24例EGE患者确诊时平均年龄44.4岁,男性多于女性(1.4∶1);5例(20.8%)有过敏性疾病和(或)过敏史;13例(54.2%)发病有明显诱因,其中11例与饮食因素有关。临床表现以腹痛(66.7%)、腹泻(58.3%)为主。14例(58.3%)外周血EOS计数升高。腹部超声/CT检查提示3例大量腹水。内镜下表现多为黏膜点、片状充血水肿、糜烂、溃疡。内镜活检结直肠(80.0%)、回肠末端(80.0%)、十二指肠(75.0%)EOS浸润阳性率最高;根据浸润深度,黏膜型19例(79.2%),肌层型2例(8.3%),浆膜型3例(12.5%)。糖皮质激素联合对症支持治疗可迅速缓解症状,但约半数患者因饮食不当或停药复发。结论:EGE临床少见,糖皮质激素联合对症支持治疗有效但易复发。当怀疑EGE时应同时完善胃镜和结肠镜检查,并多部位、多点取活检,尤其是在结直肠、回肠末端和十二指肠取活检以提高诊断率。 | 刘佳 张志文 丁杰 王新 | 2019 | 胃肠病学2019，24，6： | 9 |
| 16 | 儿童嗜酸细胞性胃肠炎研究进展显示文摘儿童嗜酸细胞性胃肠炎(EG)是一种少见的胃肠道疾病。目前发病机制不甚明确,可能是对外源性或内源性变应原的全身或局部变态反应所致。嗜酸性粒细胞浸润的范围和深度导致该病临床表现的多样化。诊断的金标准取决于内镜多点活检、腹水找嗜酸性粒细胞及腹腔镜检查等。治疗主要有激素治疗及其他药物治疗。近年来对该病的临床诊治有许多新的观点,现就儿童EG临床研究进展作一综述。 | 张劼为 胡志红 | 2011 | 实用儿科临床杂志2011，26，19： | 5 |
| 17 | 嗜酸粒细胞性胃肠炎内镜特征及诊治分析(附21例报道)显示文摘目的探讨嗜酸粒细胞性胃肠炎(EGE)的临床表现,观察其多样性,减少误诊漏诊,提高临床诊治率。方法回顾性分析该院2008年-2016年消化内科住院诊治的EGE患者临床资料,对其临床表现、诊断经过及方法、确诊依据及治疗进行分析、总结。结果最终确诊21例患者临床表现无特异性,分别以腹痛、腹泻,腹胀、伴恶心和呕吐等就诊入院;多数有哮喘病史、皮肤或药物食物过敏史。临床分型以黏膜型为主16例,浆膜型3例,混合型2例。外周血中性粒细胞百分比及嗜酸性粒细胞比例增高;部分骨髓增生活跃,嗜酸性粒细胞比例增高;腹水化验嗜酸性粒细胞比例增高;胃肠镜见黏膜充血、糜烂和溃疡等表现;腹部CT亦可见肠壁增厚、可见腹水;19例患者激素治疗有效治愈。结论 EGE是可以治愈的疾病,因其临床表现多样性,需得到更多临床医生及病理科医师的认识及关注,以尽早诊断及治疗,避免误诊及漏诊。 | 丛春莉 王丽萍 陈平 | 2018 | 中国内镜杂志2018，24，1： | 5 |
| 18 | 嗜酸细胞性胃肠炎的诊治显示文摘嗜酸细胞性胃肠炎(eosinophilic gastroenteritis,EG),亦称嗜酸性胃肠炎,是一种以胃肠道组织中嗜酸性粒细胞异常浸润为主要特征的罕见胃肠道疾病,细胞浸润可以是弥散性或局限性的,病变可累及从食管到直肠整个胃肠道壁各层,临床表现多样,缺乏特异性,易误诊漏诊。 | 康晋 秦耿 | 2012 | 中日友好医院学报2012，26，4： | 4 |
| 19 | 小儿嗜酸细胞性胃肠炎1例显示文摘 | 程子禾 | 2008 | 国际内科学杂志2008，35，6： | 4 |
| 20 | 小肠粘膜活检对9例嗜酸细胞性小肠炎患者的诊断价值显示文摘目的探讨小肠粘膜活检对嗜酸细胞性小肠炎的诊断价值。方法回顾性分析9例嗜酸细胞性胃肠炎患者的一般资料、临床表现、实验室检查、内镜和小肠造影表现。结果9例患者中,男性4例,女性5例。平均年龄43.7岁。临床主要表现为腹痛9例,腹泻5例,腹胀4例,恶心4例,呕吐4例,腹水2例。9例嗜酸细胞性小肠炎,1例病变同时累及食道,5例累及胃,5例累及十二指肠,3例累及结肠。结论小肠粘膜活检病理检查对嗜酸粒细胞性小肠炎具有重要的诊断价值。 | 王爱英 于莉莉 孟灵梅 | 2005 | 临床内科杂志2005，22，8： | 4 |
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