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		题名	作者	年代	出处	被引量
	1	Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease显示文摘Selective Ig M deficiency(s IGMD)is very rare;it may be associated with celiac disease(CD).We present the case of an 18-year-old man with s IGMD masking seronegative CD.Symptoms included abdominal pain,diarrhea and weight loss.Laboratory tests showed reduced Ig M,DQ2-HLA and negative anti-transglutaminase.Villous atrophy and diffuse immature lymphocytes were observed at histology.Tissue transglutaminase m RNA mucosal levels showed a 6-fold increase.The patient was treated with a gluten-free diet(GFD)and six months later the symptoms had disappeared,the villous architecture was restored and mucosal tissue transglutaminase m RNA was comparable to that of healthy subjects.After 1 year of GFD,a complete restoration of normal Ig M values was observed and duodenal biopsy showed a reduction of immature lymphocytes and normal appearance of mature immune cells.	Lucia Montenegro Domenico Piscitelli Floriana Giorgio Claudia Covelli Maria Grazia Fiore Giuseppe Losurdo Andrea Iannone Enzo Ierardi Alfredo Di Leo Mariabeatrice Principi	2014	World Journal of Gastroenterology2014，20，46：	0

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