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| 1 | 钩藤有效成分防治帕金森病药理机制研究进展显示文摘帕金森病是常见的中老年神经系统变性疾病,严重影响患者的生活质量,其发病机制多样,临床尚缺乏明确有效的治疗药物。钩藤作为治疗脑系病症的常用中药之一,具有息风定惊、清热平肝的功效。现代药理研究发现,钩藤的主要成分包括生物碱类、黄酮类、萜类、酯类等,其有效成分具有抗氧化、抗炎、免疫调节等药理作用,能通过抗氧化应激、减少神经元细胞凋亡、调节自噬、抗神经炎症等方式对帕金森病起到防治作用。目前关于钩藤防治帕金森病的药理机制研究主要集中在动物实验,缺乏足够的临床验证,且钩藤有效成分药理作用和不同剂型对其有效成分的影响有待深入研究,同时其药理机制中涉及的信号通路和调控分子较多且复杂,其关键的调控靶点亦不明确。下一步可从上述方面入手进行实验研究,为帕金森病的临床用药和新药开发提供更多参考。 | 高伶俪 徐冰 李涛 王颍 王莎 | 2023 | 江苏中医药2023，55，10： | 1 |
| 2 | Targeting autophagy and beyond:Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy显示文摘AbstracBteclin-1 is the firstly-identified mammalian protein of the autophagy machinery,which functions as a molecular scaffold for the assembly of PI3KC3(class II phosphatidylinositol 3 kinase)complex,thus controlling autophagy induction and other cellular trafficking events.Notably,there is mounting evidence establishing the implications of Beclin-1 in diverse tumorigenesis processes,including tumor suppression and progression as well as resistance to cancer therapeutics and CSC(cancer stem-like cell)maintenance.More importantly,Beclin-1 has been confirmed as a potential target for the treatment of multiple cancers.In this review,we provide a comprehensive survey of the structure,functions,and regulations of Beclin-1,and we discuss recent advances in understanding the controversial roles of Beclin-1 in oncology.Moreover,we focus on summarizing the targeted Beclin-1-regulating strategies in cancer therapy,providing novel insights into a promising strategy for regulating Beclin-1 to improvecancer therapeutics in thefuture. | Jing Ye Jin Zhang Yanghui Zhu Lian Wang Xian Jiang Bo Liu Gu He | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
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