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| 1 | 低浓度过氧化氢预处理骨髓间充质干细胞对创面愈合的促进作用显示文摘目的:观察低浓度过氧化氢(H2O2)预处理骨髓间充质干细胞(BMSCs)移植到大鼠组织缺损创面后BMSCs在创面的存活情况及其对创面的促愈合作用。方法:75只SD大鼠,于背部中线靠颈侧制备直径1cm的圆形全层皮肤缺损。按随机数字表法分为3组(每组25只):生理盐水组、单纯BMSCs组和H2O2预处理BMSCs组。在伤后即刻,分别经尾静脉注射等体积(0.5ml)的生理盐水、CM-Dil标记的BMSOs悬液或50umol/LH2O2预处理12h并经CM—Dil标记的BMSCs。伤后0~15d创面拍照,用ImageProplus5.0图像分析软件分析图像,计算刨面愈合率;伤后1、2、5d荧光显微镜下观察两BMSCs组创面BMSCs的数量;CD31免疫组化染色观察创面微血管密度的变化。结果:①创面干细胞数量:移植H2O2预处理的BMSCs后,创面干细胞数量明显多于单纯BMSCS移植组(P〈0.05和P〈0.01)。与伤后第1天比较,单纯BMSCs组伤后第2天和第5天创面干细胞数量显著减少(P〈0.05);而预处理组创面干细胞数量虽然也呈进行性减少,但3个时相点创面的干细胞数量差异没有显著性(P〉0.05)。②创面愈合率:创伤后5~15d,单纯BMSCs组和H2O2预处理BMSOs组创面愈合率均明显高于生理盐水组(P〈0.05或P〈0.01);创伤后5~10d,H2O2预处理组创面愈合率明显高于单纯BMSOs组(P〈0.05)。③创面微血管数量:CD31免疫组化结果显示,伤后3d,两BMSOs治疗组之间血管数量差异无显著性;伤后5、7、10d,H2O2预处理组创面微血管数量显著多于单纯BMSCs组(P〈0.05)。结论:BMSCs经低浓度H2O2预处理再移植到创面,可以延长移植干细胞在创面的存活时间,并具有更好的促进创面愈合和血管生成的修复潜能。 | 梁东兰 黄宏 荆昭 徐祥 刘晓萍 | 2016 | 感染.炎症.修复2016，17，3： | 2 |
| 2 | Macrophage Polarization in Skin Wound Healing:Progress in Biology and Therapeutics显示文摘The morphological and functional barriers caused by pathological scars are extremely painful for patients.Up to now,pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists worldwide.Macrophage polarization has shown a non-negligible effect on wound healing and scar formation.However,the role of macrophages in wound healing and pathological scar formation is still controversial.To summarize the latest data on probing biological functions of macrophage polarization in wound healing and scar formation and target macrophages in wound healing,we particularly paid attention to studies on different groups of macrophages,the transition among those groups,and modulators regulating the transition process.A comprehensive understanding of macrophage polarization in wound healing is certain to facilitate the development of new and efficient therapeutic modalities for pathological scar. | 陈露 程丽英 陈田 张余光 张建明 | 2022 | Journal of Shanghai Jiaotong university(Science)2022，27，2： | 0 |
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