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| 1 | P53与肿瘤代谢的最新研究进展显示文摘由TP53编码的P53蛋白是防止细胞癌变所需的关键因子,有广泛而强大的功能。P53在诱导细胞周期停滞、DNA损伤修复、细胞凋亡和衰老等过程中发挥重要作用,且这些功能的丧失不会使P53失去抑癌活性。新陈代谢是生命的基础,代谢异常导致多种疾病如肿瘤的发生,是癌症进展的主要驱动力之一。最近研究发现P53在调节全身代谢中起关键作用。P53介导的细胞代谢调节是控制肿瘤发生、发展的基本机制,有助于抑制肿瘤活性。本文就P53与葡萄糖、脂肪酸、氨基酸和核苷酸代谢的关系进行综述,并梳理肿瘤发展中P53在这些代谢调控中的复杂机制和最新研究进展。 | 翟海晖 刘元祺 张从政 官立萍 韩涛 | 2023 | 中国癌症杂志2023，33，11： | 1 |
| 2 | Supramolecular host-guest nanosystems for overcoming cancer drug resistance显示文摘Cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients.The emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld,providing a potential solution to this challenge.Compared with conventional chemotherapeutic platforms,supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake,reducing drug efflux,activating drugs,and inhibiting DNA repair.Herein,we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this field.It is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems. | Sha Wu Miaomiao Yan Minghao Liang Wenzhi Yang Jingyu Chen Jiong Zhou | 2023 | Cancer Drug Resistance2023，6，4： | 0 |
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