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| 1 | Drug resistance in glioblastoma: from chemo- to immunotherapy显示文摘As the most common and aggressive type of primary brain tumor in adults,glioblastoma is estimated to end over 10,000 lives each year in the United States alone.Stand treatment for glioblastoma,including surgery followed by radiotherapy and chemotherapy(i.e.,Temozolomide),has been largely unchanged since early 2000.Cancer immunotherapy has significantly shifted the paradigm of cancer management in the past decade with various degrees of success in treating many hematopoietic cancers and some solid tumors,such as melanoma and non-small cell lung cancer(NSCLC).However,little progress has been made in the field of neuro-oncology,especially in the application of immunotherapy to glioblastoma treatment.In this review,we attempted to summarize the common drug resistance mechanisms in glioblastoma from Temozolomide to immunotherapy.Our intent is not to repeat the well-known difficulty in the area of neuro-oncology,such as the blood-brain barrier,but to provide some fresh insights into the molecular mechanisms responsible for resistance by summarizing some of the most recent literature.Through this review,we also hope to share some new ideas for improving the immunotherapy outcome of glioblastoma treatment. | Sachin Sharma Oksana Chepurna Tao Sun | 2023 | Cancer Drug Resistance2023，6，4： | 0 |
| 2 | 基于双重类酶活性钯负载氧化石墨烯纳米酶对脑胶质细胞凋亡的影响显示文摘目的:构建钯负载氧化石墨(GO@Pd)纳米酶,探究其类酶活性对脑胶质细胞凋亡的影响。方法:通过原位生长法合成GO@Pd纳米酶并进行表征;体外检测GO@Pd的类超氧化物歧化酶(SOD)活性、类过氧化物酶(POD)活性和消耗谷胱甘肽(GSH)的能力;并利用亚甲基蓝检测其羟基自由基(·OH^(-))的生成;通过细胞增殖试剂盒评价GO@Pd的体外生物安全性;分别将Pd、GO和GO@Pd与人脑星形胶质母细胞瘤(U-118MG)细胞共同孵育,利用DCFH-DA荧光探针检测各组细胞内活性氧(ROS)水平;通过线粒体膜电位染色检测各组细胞内线粒体膜电位变化。结果:经一系列材料表征表明成功制备了大小均一、分散性良好的GO@Pd纳米酶;类酶活性检测结果显示,GO@Pd同时拥有类SOD和类POD双重类酶活性,并且可以催化H_(2)O_(2)生成·OH^(-)和消耗GSH;当GO@Pd浓度在0~100μg/mL之间,C8-D1A细胞的活率保持在90%以上;与空白对照组相比,GO@Pd组的U-118MG细胞内ROS水平显著升高(P<0.001),并且其线粒体膜电位染色结果红色/绿色荧光强度比值显著降低(P<0.0001)。结论:成功制备了具有双重酶样活性的GO@Pd纳米酶,且其可以通过促进胶质瘤细胞内ROS生成,诱导线粒体损伤,从而引发胶质瘤细胞凋亡。 | 肖洁 梁超怡 张李泽艾 刘斯佳 | 2023 | 广西医科大学学报2023，40，4： | 0 |
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