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| 1 | 三阴性乳腺癌遗传易感性研究进展显示文摘三阴性乳腺癌(TNBC)是一类治疗困难、预后较差、术后早期易复发且易转移的乳腺癌。发病呈低龄化趋势,种族差异大,具有明显的遗传易感性,因此迫切需要阐明TNBC的遗传风险因素,找到精准的治疗靶点。不同亚型的TNBC之间很难找到可靠的特征性基因及其多态性。为制定有效的TNBC预防策略及找寻有效的治疗靶点,现系统综述近年来与不同亚型TNBC相关的易感基因及其多态性,以期找到可靠的生物标志物,为针对特定分子途径的药物研发提供新的思路。 | 张丽佳 刘佳芮 张沅 陈薪宇 王信 张怡 | 2023 | 肿瘤防治研究2023，50，8： | 0 |
| 2 | Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer显示文摘Sentinel lymph nodes(SLNs)are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage.The pathological status of these LNs can predict that of the entire axillary lymph node.Therefore,the accurate identification of SLNs is necessary for sentinel lymph node biopsy(SLNB)to replace axillary lymph node dissection(ALND).The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs.Some of the SLN tracers that have been identified include radioisotope,nano-carbon,indocyanine green(ICG),and methylene blue(MB).However,these tracers have certain limitations,such as pigmentation,radiation dangers,and the requirement for costly detection equipment.Ultrasound contrast agents(UCAs)have good specificity and sensitivity,and thus can compensate for some shortcomings of the mentioned tracers.This technique is also being applied to SLNB in patients with breast cancer,and can even provide an initial judgment on SLN status.Contrast-enhanced ultrasound(CEUS)has the advantages of high distinguishability,simple operation,no radiation harm,low cost,and accurate localization;therefore,it is expected to replace the traditional biopsy methods.In addition,it can significantly enhance the accuracy of SLN localization and shorten the operation time. | Qiuhui YANG Yeqin FU Jiaxuan WANG Hongjian YANG Xiping ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，11： | 0 |
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