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| 1 | 外用Nr-CWS治疗高危型HPV持续感染及宫颈癌前病变合并高危型HPV感染的效果显示文摘目的:探究外用红色诺卡氏菌细胞壁骨架(Nr-CWS)治疗高危型HPV持续感染及宫颈癌前病变合并高危型HPV感染的效果。方法:选取2020年3月—2021年5月我院收治的116例宫高危型人乳头瘤病毒(HPV)持续感染及宫颈癌前病变合并HPV感染患者作为观察对象,并根据患者的意愿将其分为试验组、对照组A、对照组B以及空白组,各29例。试验组采取外用Nr-CWS治疗,对照组A采取保妇康栓置于阴道治疗,对照组B采取重组人干扰素α-2b置于阴道治疗,空白组不予处理。对比组间患者临床疗效及不良反应情况。结果:停止治疗3个月后,试验组有效率与HPV转阴率显著高于其他3组(P<0.05);停止治疗6个月后,试验组HPV转阴率显著高于空白组(P<0.05),试验组、对照组A及对照组B有效率均显著高于空白组(P<0.05)。治疗期间,组间出现腰痛、白带异常、下腹坠胀及特殊气味等不良反应情况对比,差异无统计学意义(P>0.05)。结论:外用Nr-CWS治疗高危型HPV持续感染及宫颈癌前病变合并高危型HPV感染,临床疗效显著,患者可耐受,值得推广。 | 王君霞 吴璇 段艳 | 2023 | 医学理论与实践2023，36，11： | 0 |
| 2 | Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis显示文摘Mesenchymal stem cell(MSC)-derived exosomes(Exos)were reported to a prospective candidate in accelerating diabetic wound healing due to their pro-angiogenic effect.MSCs pretreated with chemistry or biology factors were reported to advance the biological activities of MSC-derived exosomes.Hence,this study was designed to explore whether exosomes derived from human umbilical cord MSCs(hucMSCs)preconditioned with Nocardia rubra cell wall skeleton(Nr-CWS)exhibited superior proangiogenic effect on diabetic wound repair and its underlying molecular mechanisms.The results showed that Nr-CWS-Exos facilitated the proliferation,migration and tube formation of endothelial cells in vitro.In vivo,Nr-CWS-Exos exerted great effect on advancing wound healing by facilitating the angiogenesis of wound tissues compared with Exos.Furthermore,the expression of circIARS1 increased after HUVECs were treated with Nr-CWS-Exos.CircIARS1 promoted the pro-angiogenic effects of Nr-CWS-Exos on endothelial cells via the miR-4782-5p/VEGFA axis.Taken together,those data reveal that exosomes derived from Nr-CWS-pretreated MSCs might serve as an underlying strategy for diabetic wound treatment through advancing the biological function of endothelial cells via the circIARS1/miR-4782-5p/VEGFA axis. | LI Qiang GUO Lei WANG Jian TAO Shengjun JIN Peisheng | 2023 | Chinese Journal of Natural Medicines2023，21，3： | 0 |
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