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| 1 | 侵及中枢神经系统的单形性亲上皮性肠道T细胞淋巴瘤1例并文献复习显示文摘目的提高对侵及中枢神经系统(CNS)的单形性亲上皮性肠道T细胞淋巴瘤(MEITL)的认识。方法回顾性分析哈尔滨医科大学附属肿瘤医院2019年11月收治的1例MEITL治疗后出现侵及CNS的临床病理资料,并复习相关文献。结果患者为59岁女性,因肠穿孔急诊入院治疗,结合病理检查结果诊断为MEITL。予CHOP方案治疗3个疗程,中断治疗3个月后出现脑转移,患者拒绝继续治疗,于2020年5月因呼吸循环衰竭死亡。结论MEITL临床罕见。目前MEITL缺乏规范、有效的治疗措施,在治疗的同时应加强对CNS侵犯的预防。 | 王歆雅 徐秋婷 于晓宇 陈雪 全丽娜 | 2022 | 白血病.淋巴瘤2022，31，12： | 0 |
| 2 | 以腹泻为主要临床表现的肠病相关T细胞淋巴瘤1例显示文摘目的:探讨以长期腹泻为主要临床表现的肠病相关T细胞淋巴瘤(EATL)的病程进展、诊断方法及预后。方法:观察和分析1例EATL患者临床资料、实验室检查、影像学评估及病理学特征。结果:EATL可表现为长期腹泻伴有体质量下降。累及部位不仅限于小肠,还可以累及结肠和直肠。结论:EATL是一种非常罕见的来源于T细胞小肠上皮内淋巴细胞的肿瘤。在腹泻患者诊治过程中,常规治疗无效且未能明确病因时,需要多部位获取胃肠道病理标本,并且应考虑存在EATL的可能。 | 杨林 韩真 何池义 周爽 王巍 | 2023 | 皖南医学院学报2023，42，2： | 0 |
| 3 | Surgical management of monomorphic epitheliotropic intestinal Tcell lymphoma followed by chemotherapy and stem-cell transplant:A case report and review of the literature显示文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity.MEITL patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy.Currently,there are no standardized treatment protocols,and the optimal therapy remains unclear.CASE SUMMARY We report a case of MEITL that was initially considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one cycle.The 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 pounds.Within 2 wk,the size of the mass considerably increased on computed tomography scans.The patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative pathology.Immunophenotypically,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and TIA-1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian patients.Immediate laparotomy should then be carried out followed by chemotherapy and stem-cell transplant. | Abdul Saad Bissessur Ji-Chun Zhou Ling Xu Zhao-Qing Li Si-Wei Ju Yun-Lu Jia Lin-Bo Wang | 2022 | World Journal of Gastrointestinal Oncology2022，14，11： | 0 |
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