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1Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a very deadly disease.HCC initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.Activation of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth.In this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years.These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.Fang Wang Peter Breslin S J Wei Qiu 2021Liver Research2021,5,4:3
2Hepatocellular carcinoma diagnosis and treatment: An overview显示文摘For decades,chronic liver disease has remained an increasing global health threat.Despite vaccines and antiviral therapies,both hepatitis B and C remain enormous clinical problems.Hepatic steatosis has become a rapidly increasing worldwide concern that can be appropriately characterized as an evolving epidemic.1 Aroundtheworld alcohol consumption is onthe rise,while autoim-mune conditions and environmental toxins all continue contrib-uting to this seemingly universal health dilemma.The common denominator of chronic liver disease is progressive hepatic inflam-mation leading to fibrosis and cirrhosis.Steven D.Colquhoun Yu-Jui Yvonne Wan 2020Liver Research2020,4,4:1
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