共被期刊论文引用了2次
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| 1 | Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers显示文摘Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy. | Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 10 |
| 2 | 纳米活性炭对中药或植物活性成分的吸附与缓释研究进展显示文摘文章综述药物缓释制剂的作用和种类,评述纳米活性炭作为活性成分缓释载体的理化特性,归纳近年来国内外对纳米活性炭作为中药或植物活性成分缓释制剂载体的研究进展,指出纳米活性炭的制备以及纳米活性炭作为活性成分缓释制剂遇到的技术瓶颈和今后的研究方向。 | 曾朝彦 李湘洲 张胜 黄丹 | 2016 | 食品与机械2016，32，9： | 2 |
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