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| 1 | Carbon Nanotubes in Biology and Medicine:In vitro and in vivo Detection,Imaging and Drug Delivery显示文摘Carbon nanotubes exhibit many unique intrinsic physical and chemical properties and have been intensively explored for biological and biomedical applications in the past few years.In this comprehensive review,we summarize the main results from our and other groups in this field and clarify that surface functionalization is critical to the behavior of carbon nanotubes in biological systems.Ultrasensitive detection of biological species with carbon nanotubes can be realized after surface passivation to inhibit the non-specific binding of biomolecules on the hydrophobic nanotube surface.Electrical nanosensors based on nanotubes provide a label-free approach to biological detection.Surface-enhanced Raman spectroscopy of carbon nanotubes opens up a method of protein microarray with detection sensitivity down to 1 fmol/L.In vitro and in vivo toxicity studies reveal that highly water soluble and serum stable nanotubes are biocompatible,nontoxic,and potentially useful for biomedical applications.In vivo biodistributions vary with the functionalization and possibly also size of nanotubes,with a tendency to accumulate in the reticuloendothelial system(RES),including the liver and spleen,after intravenous administration.If well functionalized,nanotubes may be excreted mainly through the biliary pathway in feces.Carbon nanotube-based drug delivery has shown promise in various In vitro and in vivo experiments including delivery of small interfering RNA(siRNA),paclitaxel and doxorubicin.Moreover,single-walled carbon nanotubes with various interesting intrinsic optical properties have been used as novel photoluminescence,Raman,and photoacoustic contrast agents for imaging of cells and animals.Further multidisciplinary explorations in this field may bring new opportunities in the realm of biomedicine. | Zhuang Liu Scott Tabakman Kevin Welsher Hongjie Dai | 2009 | Nano Research2009，2，2： | 50 |
| 2 | 碳纳米管与蛋白质相互作用的机制及其生物效应显示文摘由于碳纳米管本身具有诸多优异的物理化学性质,已经在生物学和医学领域展现出潜在的应用前景.从纳米科技的长期发展而言,碳纳米管的安全应用及其潜在的毒理学评价显得非常重要.众所周知,碳纳米管用于载药、诊断或成像等生物医学领域时,会与生物体内的各种蛋白质产生相互作用,进而会改变碳纳米管自身的理化性质和影响蛋白质的构象及功能,从而引发不同的生物反应.而通过将蛋白质连接到碳纳米管上制备的生物器件,既降低了碳纳米管潜在毒性又为其安全生物应用开拓了市场.因此深入阐述碳纳米管-蛋白质相互作用的机制及后续的生物效应,对发展碳纳米管的安全应用具有重要意义. | 杜江锋 葛翠翠 | 2015 | 科学通报2015，60，31： | 2 |
| 3 | Boron nitride nanotube growth via boron oxide assisted chemical vapor transport-deposition process using LiNO3 as a promoter显示文摘高纯净的直、分离的 multiwalled 硼氮化物 nanotubes (BNNT ) 作为一个倡导者用浮雕 3 与氨经由硼氧化物蒸汽反应被种。硼氧化物的仅仅踪迹数量被精力散的 X 光检查(EDX ) 和拉曼光谱学在 BNNT 作为杂质检测。硼氧化物蒸汽从 B 的混合物被产生, FeO ,吗并且 MgO 粉末加热了到 1,150 爠灥潲畤楣汢?湡?楨桧祬愠瑣癩??卒攠晦'太B?獕湩?桴?牵档湩氭歩?杁??牡慲獹愠??卒猠'T瑳慲整?ㄠ????猯灵￣?楤畢祴?桰桴污瑡?愨洠浥敢?景瀠慬瑳捩穩牥?慦業祬?湡??‵殣?岣僫篤蔿藏????鐿???????脿???鯀魈鱋??︿????????????璣阿??鲣??觎????鑔鍽???????????恘? 恘 ?? | Andrei T. Matveev Konstantin L. Firestein Alexander E. Steinman Andrey M. Kovalskii Oleg I. Lebedev Dmitry V. Shtansky Dmitri Golberg | 2015 | Nano Research2015，8，6： | 2 |
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