| 1 | A global assessment of recent trends in gastrointestinal cancer and lifestyle-associated risk factors显示文摘Background:Gastrointestinal(GI)cancers were responsible for 26.3%of cancer cases and 35.4%of deaths worldwide in 2018.This study aimed to analyze the global incidence,mortality,prevalence,and contributing risk factors of the 6 major GI cancer entities[esophageal cancer(EC),gastric cancer(GC),liver cancer(LC),pancreatic cancer(PC),colon cancer,and rectal cancer].Methods:Using the Global Cancer Observatory and the Global Health Observatory databases,we reviewed the current GI cancer incidence,prevalence,and mortality,analyzed the association of GI cancer prevalence with national human development indices(HDIs),identified the contributing risk factors,and estimated developing age-and sex-specific trends in incidence and mortality.Results:In 2020,the trend in age-standardized rate of incidence of GI cancers closely mirrored that of mortality,with the highest rates of LC,EC,and GC in Asia and of colorectal cancer(CRC)and PC mainly in Europe.Incidence and mortality were positively,but the mortality-to-incidence ratio(MIR)was inversely correlated with the national HDI levels.High MIRs in developing countries likely reflected the lack of preventive strategies and effective treatments.GI cancer prevalence was highest in Europe and was also positively correlated with HDIs and lifestyle-associated risk factors,such as alcohol consumption,smoking,obesity,insufficient physical activity,and high blood cholesterol level,but negatively correlated with hypertension and diabetes.Incidences of EC were consistently and those of GC mostly decreasing,whereas incidences of CRC were increasing in most countries/regions,especially in the younger populations.Incidences of LC and PC were also increasing in all age-gender populations except for younger males.Mortalities were decreasing for EC,GC,and CRC in most countries/regions, and age-specific trends were observed in PC and LC with adecrease in the younger but an increase in the older population.Conclusions: On the global scale, higher GI cancer burden was accompanied,for the most part, by factors associated with the so-called Western lifestylereflected by high and very high national HDI levels. In countries/regionswith very high HDI levels, patients survived longer, and increasing GI cancercases were observed with increasing national HDI levels. Optimizing GI cancer prevention and improving therapies, especially for patients with comorbidmetabolic diseases, are thus urgently recommended. | Lili Lu Christina S.Mullins Clemens Schafmayer Sebastian Zeißig Michael Linnebacher | 2021 | Cancer Communications2021，41，11： | 6 |
| 2 | 2型糖尿病患者血清糖化血红蛋白水平与甲状腺癌发病风险的关系显示文摘目的:检测2型糖尿病(T2DM)患者血清糖化血红蛋白(HbA1c)水平,探讨血清HbA1c水平与甲状腺癌发病风险的关系。方法:选取2017年1月至2019年6月在本院收治的T2DM患者(观察组)328例作为研究对象,其中未并发甲状腺癌T2DM患者(未并甲状腺癌组)297例,并发甲状腺癌T2DM患者(并甲状腺癌组)31例,选取同期健康体检者(对照组)330例作为对照。采集受试者清晨空腹外周血并提取血清,全自动生化分析仪检测血清HbA1c、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)以及低密度脂蛋白胆固醇(LDL-C)水平;Pearson法分析T2DM患者血清HbA1c水平与TC、TG、HDL-C、LDL-C水平的相关性;采用多因素Logistic回归分析影响T2DM患者并发甲状腺癌的因素。结果:与对照组相比,观察组T2DM患者血清HbA1c、TC、TG、LDL-C水平、甲状腺癌发病率均明显升高(P<0.05),HDL-C水平明显降低(P<0.05);T2DM患者血清HbA1c水平与TC、TG水平明显正相关(P<0.05),与HDL-C水平明显负相关(P<0.05);与未并甲状腺癌组相比,并甲状腺癌组T2DM患者血清HbA1c、TC、TG水平明显升高(P<0.05),HDL-C水平明显降低(P<0.05),LDL-C水平无明显变化(P>0.05);血清HbA1c、TC、TG水平均为影响T2DM患者并发甲状腺癌的危险因素(P<0.05),血清HDL-C水平为影响T2DM患者并发甲状腺癌的保护因素(P<0.05)。结论:T2DM患者并发甲状腺癌可能与血清HbA1c水平升高有关,HbA1c可能通过调控血脂水平,增加T2DM患者并发甲状腺癌的风险,可作为临床上判断T2DM患者并发甲状腺癌风险的依据。 | 常杰 朴金龙 谢莉莉 | 2020 | 现代肿瘤医学2020，28，15： | 5 |
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