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1不同领域现实世界临床研究证据转化的应用策略显示文摘参考已发布的政策法规指导意见,通过文献检索现实世界研究相关的专家共识指南,总结国内外现实世界临床研究不同领域的研究现况,归纳不同领域现实世界临床研究证据转化的观点,结合典型案例,为现实世界数据转化为现实世界证据的应用提供策略支持。李昱佳 陈垂雄 黄丽红 汪旻晖 李晨 邱婧君 赵杨 谢海棠 王陵 2021中国临床医学2021,28,5:2
2The glycosylation in SARS-CoV-2 and its receptor ACE2显示文摘Coronavirus disease 2019(COVID-19),a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected more than 235 million individuals and led to more than 4.8 million deaths worldwide as of October 52021.Cryo-electron microscopy and topology show that the SARS-CoV-2 genome encodes lots of highly glycosylated proteins,such as spike(S),envelope(E),membrane(M),and ORF3a proteins,which are responsible for host recognition,penetration,binding,recycling and pathogenesis.Here we reviewed the detections,substrates,biological functions of the glycosylation in SARS-CoV-2 proteins as well as the human receptor ACE2,and also summarized the approved and undergoing SARS-CoV-2 therapeutics associated with glycosylation.This review may not only broad the understanding of viral glycobiology,but also provide key clues for the development of new preventive and therapeutic methodologies against SARS-CoV-2 and its variants.Yanqiu Gong Suideng Qin Lunzhi Dai Zhixin Tian 2021Signal Transduction and Targeted Therapy2021,6,12:0
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