共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dimeric G-quadruplex DNA Structure in the Proximal Promoter of VEGFR-2 Reveals a New Drug Target to Inhibit Tumor Angiogenesis显示文摘Vascular endothelial growth factor(VEGF)regulates tumor angiogenesis,which is active on the endothelium via VEGF receptor 2(VEGFR-2).The proximal promoter region of VEGFR-2(termed as VEGFR-2 DNA)is guanine-rich,forming G-quadruplex(G4)structures.Here,we demonstrate that VEGFR-2 DNA consists of one symmetrically dimeric 14-mer G4-DNA and one 12-mer sequence-palindromic dsDNA.This G4-DNA adopts an unprecedented folding with five stacked tetrads linked by four broken strands.Its 5’-end part contains an A-tetrad A^(1)•A^(4)•A^(1’)•A^(4’)and one G-tetrad G^(3)•G^(5)•G^(3’)•G^(5’)with two V-shaped loops and two one-nt edge-type loops.Its 3’-end part includes three G-tetrads G^(10)•G^(6)•G^(10’)•G^(6’),G^(11)•G^(7)•G^(11’)•G^(7’)(central)and G^(12)•G^(8)•G^(12’)•G^(8’)spanned by two double-chain-reversal one-nt(C^(9)or C^(9’))loops.Bases G^(13)and G^(13’)stack with G-tetrad G^(12)•G^(8)•G^(12’)•G^(8’).These characteristics make this G4-DNA more stable than reported VEGFR-17T G4 structure.The dsDNA connects with G4-DNA without any interactions,generating a linear assembly with G4-DNA structural bulges.These studies uncover new structural features of VEGFR-2 DNA as a potential drug target by inhibiting VEGFR-2 expression,thereby tumor angiogenesis. | Yipeng Zhang Wenxian Lan Chunxi Wang Hongjuan Xue Chunyang Cao | 2022 | Chinese Journal of Chemistry2022，40，18： | 0 |
| 2 | 靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展显示文摘肿瘤基因MYC在人类70%癌细胞中高表达,抑制其转录是治疗肿瘤的有效手段.c-MYC启动子区P1近端的核酸酶超敏元件III1(NHE III1)控制MYC基因近90%的转录激活.NHE III1区域富含碱基G序列并且形成G-四链体(G4),调控c-MYC基因转录,是抗肿瘤药物靶标.但G4-DNA和G4-RNA的三维结构高度相似,小分子与其他G4(如端粒G4、mRNA G4、c-Kit G4等)的非特异性作用会产生小分子药物“脱靶”效应,同时小分子药物会诱导其他G4形成从而干扰正常细胞的功能,造成靶向c-MYC G4抗癌药物设计困难.本文综述了近些年靶向肿瘤因子c-MYC G4-DNA的小分子药物研究进展,及核磁共振(NMR)技术在G4-DNA和G4-RNA结构确定中的作用,为靶向c-MYC G4-DNA的小分子药物设计等相关研究工作提供参考. | 胡晓东 蓝文贤 王春喜 曹春阳 | 2021 | 波谱学杂志2021，38，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员