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| 1 | Astrocytes in depression and Alzheimer’s disease显示文摘Astrocytes are an abundant subgroup of cells in the central nervous system(CNS)that play a critical role in controlling neuronal circuits involved in emotion,learning,and memory.In clinical cases,multiple chronic brain diseases may cause psychosocial and cognitive impairment,such as depression and Alzheimer’s disease(AD).For years,complex pathological conditions driven by depression and AD have been widely perceived to contribute to a high risk of disability,resulting in gradual loss of self-care ability,lower life qualities,and vast burden on human society.Interestingly,correlational research on depression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease.As a kind of multifunctional glial cell in the CNS,astrocytes maintain physiological function via supporting neuronal cells,modulating pathologic niche,and regulating energy metabolism.Mounting evidence has shown that astrocytic dysfunction is involved in the progression of depression and AD.We herein review the current findings on the roles and mechanisms of astrocytes in the development of depression and AD,with an implication of potential therapeutic avenue for these diseases by targeting astrocytes. | Yang Liao Qu Xing Qianqian Li Jing Zhang Ruiyuan Pan Zengqiang Yuan | 2021 | Frontiers of Medicine2021，15，6： | 4 |
| 2 | 脑内星形胶质细胞-神经元相互作用参与抑郁症发病研究进展显示文摘经典的观点认为星形胶质细胞是神经元的支持细胞,在大脑信息处理中没有直接作用。而越来越多的证据表明神经元-与星形胶质细胞之间相互作用功能障碍可能与各种神经和神经退行性疾病的病理学有关,近年来也逐渐成为抑郁症发病机制研究的热点。本文总结了星形胶质细胞-神经元相互作用参与抑郁症脑氧化防御、突触可塑性、脑能量代谢、神经炎症、谷氨酸循环等过程障碍的重要证据,这些证据表明星形胶质细胞-神经元之间的相互作用障碍是抑郁症发病的重要机制之一。本文还对星形胶质细胞-神经元参与抑郁症发病的新观点,以及研究中存在的问题进行了讨论,以便为后续研究提供思路和借鉴。 | 刘燕 彭梦薇 张文娴 杨铁柱 吴耀松 刘俊 任闪闪 陈玉龙 | 2023 | 中国比较医学杂志2023，33，3： | 0 |
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