共被期刊论文引用了3次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The formation and repair of DNA double-strand breaks in mammalian meiosis显示文摘Programmed DNA double-strand breaks(DSBs)are necessary for meiosis in mammals.A sufficient number of DSBs ensure the normal pairing/synapsis of homologous chromosomes.Abnormal DSB repair undermines meiosis,leading to sterility in mammals.The DSBs that initiate recombination are repaired as crossovers and noncrossovers,and crossovers are required for correct chromosome separation.Thus,the placement,timing,and frequency of crossover formation must be tightly controlled.Importantly,mutations in many genes related to the formation and repair of DSB result in infertility in humans.These mutations cause nonobstructive azoospermia in men,premature ovarian insufficiency and ovarian dysgenesis in women.Here,we have illustrated the formation and repair of DSB in mammals,summarized major factors influencing the formation of DSB and the theories of crossover regulation. | Wei Qu Cong Liu Ya-Ting Xu Yu-Min Xu Meng-Cheng Luo | 2021 | Asian Journal of Andrology2021，23，6： | 1 |
| 2 | Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites显示文摘Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are affected by various physical and chemical factors.With the development of industrialization,environmental pollutants have caused great harm to public health.Phthalates,as a class of endocrine-disrupting chemicals(EDCs),are synthesized and used in large quantities as plasticizers due to their chemical properties.They are easily released into environment because of their noncovalent interactions with substances,causing human exposure and possibly impairing ovary.In recent years,more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases.And it is urgent to study the role of methylation,gene imprinting,miRNA,and other epigenetic mechanisms in reproductive toxicology. | Hua-hua JIANG Yao-yao DU Yu-feng LI | 2021 | Current Medical Science2021，41，2： | 0 |
| 3 | Crossover patterns under meiotic chromosome program显示文摘Repairing DNA double-strand breaks(DSBs)with homologous chromosomes as templates is the hallmark of meiosis.The critical outcome of meiotic homologous recombination is crossovers,which ensure faithful chromosome segregation and promote genetic diversity of progenies.Crossover patterns are tightly controlled and exhibit three characteristics:obligatory crossover,crossover interference,and crossover homeostasis.Aberrant crossover patterns are the leading cause of infertility,miscarriage,and congenital disease.Crossover recombination occurs in the context of meiotic chromosomes,and it is tightly integrated with and regulated by meiotic chromosome structure both locally and globally.Meiotic chromosomes are organized in a loop-axis architecture.Diverse evidence shows that chromosome axis length determines crossover frequency.Interestingly,short chromosomes show different crossover patterns compared to long chromosomes.A high frequency of human embryos are aneuploid,primarily derived from female meiosis errors.Dramatically increased aneuploidy in older women is the well-known“maternal age effect.”However,a high frequency of aneuploidy also occurs in young women,derived from crossover maturation inefficiency in human females.In addition,frequency of human aneuploidy also shows other age-dependent alterations.Here,current advances in the understanding of these issues are reviewed,regulation of crossover patterns by meiotic chromosomes are discussed,and issues that remain to be investigated are suggested. | Shunxin Wang Yongliang Shang Yanlei Liu Binyuan Zhai Xiao Yang Liangran Zhang | 2021 | Asian Journal of Andrology2021，23，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员