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| 1 | 调脂通脉中药对动脉粥样硬化兔模型内皮细胞标志物的影响显示文摘目的观察动脉粥样硬化兔模型内皮细胞标志物的变化及调脂通脉中药的干预作用。方法采用高脂饲料饮食和球囊损伤颈动脉的方法复制动脉粥样硬化兔模型,随机分为正常组、模型组、假手术组、西药组(阿托伐他汀,1.1 mg/kg)和中药组(调脂通脉中药,7.3 g/kg)组,共5组,选择治疗后第6周、12周为观察点。在两个时间点,检测血脂水平;HE染色检测颈总动脉、肝脏形态学变化;ELISA检测内皮细胞标志物内皮素(ET-1)、一氧化氮合酶(e NOS)、前列环素2(PGI2)、血栓素A2(TXA2)的变化。结果两个时间点,模型组ET-1、TXA2表达增加(P<0.05)、e NOS、PGI2表达下降(P<0.05)。调脂通脉中药能够降低ET-1、TXA2水平(P<0.01),且升高e NOS、PGI2表达(P<0.05)。结论调脂通脉中药能够改善血管内皮细胞损伤,减轻动脉粥样硬化。 | 张璐 孙晴 郭书文 郑敏 苏兆铎 武建功 刘文臣 陈曦 | 2018 | 中国中医急症2018，27，10： | 5 |
| 2 | Autophagosome activity in macrophage for atherosclerotic plaques in ApoE^-/-mice enhanced by Tiaozhi Tongmai Granules显示文摘Objective:Atherosclerosis is the fundamental pathophysiologic component of cardiovascular disease,and Tiaozhi Tongmai Granules show great efficiency in the treatment of the disease.However,the mechanism of Tiaozhi Tongmai Granules is still unclear.In this study,we have combined experiments with network pharmacology to explore the antiatherosclerosis mechanism of Tiaozhi Tongmai Granules.Method:120 male ApoE/mice were randomly divided into three groups:the model group,Chinese herb group and Atorvastatin group.The model group,Atorvastatin group and Chinese herb group were fed with a high-fat diet,a high-fat diet plus atorvastatin(5.1 mg/kg/d)and a high-fat diet plus Tiaozhi Tongmai Granules(16.5 g/kg/d)for 16 weeks,respectively.Atherogenesis was identified by H&E staining.The colocalization of neutral lipid stain BODIPY and microtubule-associated protein 1 light chain 3(LC3)and the colocalization of BODIPY and lysosomal-associated membrane protein 1(LAMP1)within ApoE/mice aortic plaques were tested using fluorescence confocal microscopy and the Pearson’s coefficients were calculated.To further explore the anti-atherosclerosis mechanism of Tiaozhi Tongmai Granules,the network pharmacology was used to construct the herb-compound-target network.Results:The size of the aortic lipid plaque in the Chinese herb group and Atorvastatin group were smaller compared with the model group on the 16th week.Compared with the model group on the 16th week,the BODIPY and LC3 colocalization rate,the BODIPY and LAMP1 colocalization rate of the Chinese herb group and Atorvastatin group all presented significant increase in the aortic plaque(P<.001),showing that Tiaozhi Tongmai Granules could enhance autophagosome activity in the macrophage.In the herb-compound-target network,17 active compounds and 27 targets were obtained through literature searching and using LHRI&DAVID Bioinformatics.It was found that 23 targets were correlated with the macrophage.Some of them participated in macrophage inflammatory response,and the other targets could promote/inhibit phagocytosis of the macrophage.It was hypothesized that the active compounds of Tiaozhi Tongmai Granules were acting on these targets and having y the biological effects.Conclusions:In the progression stage of atherosclerosis,Tiaozhi Tongmai Granules can still make the macrophage have higher autophagosome activity,and play a role of anti-atherogenesis. | Chenglong Zheng Qing Sun Lu Zhang Shuwen Guo Min Zheng Yan Tang Jiangong Wu Jiani Wu Wenchen Liu Zhaoduo Su Xi Chen | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 2 |
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