共被期刊论文引用了2次
您的检索式：您选中1篇文献正在查看引证文献汇总
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptome Analysis Identifies SenZfp536,a Sense LncRNA that Suppresses Self-renewal of Cortical Neural Progenitors显示文摘Long non-coding RNAs(lncRNAs)regulate transcription to control development and homeostasis in a variety of tissues and organs.However,their roles in the development of the cerebral cortex have not been well elucidated.Here,a bioinformatics pipeline was applied to delineate the dynamic expression and potential cis-regulating effects of mouse lncRNAs using transcriptome data from 8 embryonic time points and sub-regions of the developing cerebral cortex.We further characterized a sense lncRNA,SenZfp536,which is transcribed downstream of and partially overlaps with the protein-coding gene Zfp536.Both SenZfp536 and Zfp536 were predominantly expressed in the proliferative zone of the developing cortex.Zfp536 was cis-regulated by SenZfp536,which facilitates looping between the promoter of Zfp536 and the genomic region that transcribes SenZfp536.Surprisingly,knocking down or activating the expression of SenZfp536 increased or compromised the proliferation of cortical neural progenitor cells(NPCs),respectively.Finally,overexpressing Zfp536 in cortical NPCs reversed the enhanced proliferation of cortical NPCs caused by SenZfp536 knockdown.The study deepens our understanding of how lncRNAs regulate the propagation of cortical NPCs through cis-regulatory mechanisms. | Kuan Tian Andi Wang Junbao Wang Wei Li Wenchen Shen Yamu Li Zhiyuan Luo Ying Liu Yan Zhou | 2021 | Neuroscience Bulletin2021，37，2： | 0 |
| 2 | 组蛋白去甲基化酶KDM2B在疾病发生过程中的功能研究显示文摘KDM2B(Lysine-specific demethylase 2B)是组蛋白去甲基化酶家族的一员,能够特异性地使组蛋白H3K36me2、H3K4me3和H3K79me位点去甲基化。KDM2B能够参与多种细胞活动,如细胞衰老、细胞分化、细胞增殖、细胞凋亡和干细胞的自我更新等,进而在多种疾病包括肿瘤、炎症和神经性疾病中发挥重要作用。本文对KDM2B在多种疾病发生发展过程中的功能和机制进行了综述。 | 杜鸿斌 刘琳琳 孙梦莹 王丹宇 赵春玲 田春艳 | 2020 | 生命的化学2020，40，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员