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| 1 | Motion direction prediction through spike timing based on micro Capsnet networks显示文摘Neural activity extraction and neural decoding from neural signals are an important part of critical components of brain-computer interface systems.With the development of brain-computer interface technology,the demand for precise external control and nervous activities in macaque monkey during unilateral hand grasp has increased the complexity of control and neural decoding,which puts forward higher requirements for the accuracy and stability of feature extraction and neural decoding.In this study,a micro Capsnet network architecture that consists of a few network layers,a vector feature structure,and optimization network parameters,is proposed to decrease the computing time and complexity,decrease artificial debugging,and improve the decoding accuracy.Compared with KNN,SVM,XGBOOST,CNN,Simple RNN,and LSTM,the algorithm in this study improves the decoding accuracy by 98.03%,and achieves state-of-the-art accuracy and stronger robustness.Furthermore,the proposed algorithm can further enhance the control accuracy in the brain-computer interface. | ZHANG HuaLiang LIU Ji WANG BaoZeng DAI Jun LIAN JinLing KE Ang ZHAO YuWei ZHOU Jin WANG ChangYong | 2022 | Science China(Technological Sciences)2022，65，11： | 1 |
| 2 | Transcranial direct current stimulation inhibits epileptic activity propagation in a large-scale brain network model显示文摘Transcranial direct current stimulation(tDCS)is a noninvasive technique that uses constant,low-intensity direct current to regulate brain activities.Clinical studies have shown that cathode-tDCS(c-tDCS)is effective in reducing seizure frequency in patients with epilepsy.Due to the heterogeneity and patient specificity of seizures,patient-specific epilepsy networks are increasingly important in exploring the regulatory role of c-tDCS.In this study,we first set the left hippocampus,parahippocampus,and amygdala as the epileptogenic zone(EZ),and the left inferior temporal cortex and ventral temporal cortex as the initial propagation zone(PZ)to establish a large-scale epilepsy network model.Then we set tDCS cathode locations according to the maximum average energy of the simulated EEG signals and systematically study c-tDCS inhibitory effects on the propagation of epileptic activity.The results show that c-tDCS is effective in suppressing the propagation of epileptic activity.Further,to consider the patient specificity,we set specific EZ and PZ according to the clinical diagnosis of 6 patients and establish patient-specific epileptic networks.We find that c-tDCS can suppress the propagation of abnormal activity in most patient-specific epileptic networks.However,when the PZ is widely distributed in both hemispheres,the treatment effect of c-tDCS is not satisfactory.Hence,we propose dual-cathode tDCS.For epilepsy models with a wide distribution of PZ,it can inhibit the propagation of epileptiform activity in other nodes except EZ and PZ without increasing the tDCS current strength.Our results provide theoretical support for the treatment of epilepsy with tDCS. | YU Ying FAN YuBo HAN Fang LUAN GuoMing WANG QingYun | 2023 | Science China(Technological Sciences)2023，66，12： | 0 |
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