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| 1 | 大戟属植物二萜化学成分和药理活性研究新进展显示文摘目的:了解大戟属植物中二萜化学成分和药理活性的国内外研究最新状况。方法:查阅国内外有关大戟属植物研究的文献,了解上述两方面的基本情况。结果与讨论:2019年以来,国内外学者对大戟属植物进行大量研究,发现了97种新的二萜成分。药理研究表明,一些种及二萜成分在逆转P-糖蛋白介导的多药耐药性、细胞毒性、脂肪酶抑制活性、抗病毒和抗炎等方面具有显著的活性。开展大戟属植物二萜成分研究,对开发新的药用活性成分及资源利用具有重要意义。 | 杨舜伊 袁纯红 陈业高 | 2020 | 中国野生植物资源2020，39，6： | 5 |
| 2 | Discovery of Highly Oxidized Abietane Diterpenoids from the Roots of Euphorbia fischeriana with Anti-tumor Activities显示文摘Four previously undescribed ent-abietane diterpenoids(1—4),along with eleven known analogues(5—15),were isolated from the roots of wild Euphorbia fischeriana.Their gross structures were determined via extensive spectroscopic data,and the absolute configurations were elucidated by means of single-crystal X-ray diffraction analysis,Rh2(OCOCF3)4-induced CD spectrum and ECD calculations.Their cervical carcinoma inhibition activities counteract HeLa cells were screened by MTT assay,and the structure-activity relationships were further examined.The results demonstrated that 2(IC50 value at 3.75μmol/L)was more potent than cisplatin.The underlying mechanism study revealed that 2 could distinctly induce apoptosis accompanied by increasing reactive oxygen species(ROS)production,Ca^(2+)influx and decreasing mitochondrial membrane potential.Furthermore,signal pathways including MAPKs/AKT might play a significant role in 2-induced cervical cancer cells death. | Jiang-Chun Wei Yu-Ning Gao Dong-Dong Wang Xiao-Yu Zhang San-Peng Fan Te-Ri-Gen Bao Xiao-Xu Gao Gao-Sheng Hu An-Hua Wang Jing-Ming Jia | 2021 | Chinese Journal of Chemistry2021，39，11： | 2 |
| 3 | 元胡止痛滴丸联合间苯三酚治疗顺产后宫缩痛80例效果观察显示文摘目的探讨元胡止痛滴丸联合间苯三酚在顺产后宫缩痛中的应用效果。方法选取2021年7月至2023年3月赣州市赣县区人民医院收治的80例顺产后宫缩痛产妇,按随机数字表法分为两组,各40例。对照组予以常规治疗,观察组加用元胡止痛滴丸联合间苯三酚治疗,持续治疗2~3 d。比较两组临床疗效、疼痛缓解情况、疼痛发作情况、阴道流血情况及不良反应情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组产后24 h、产后48 h时视觉模拟评分(VAS)[(2.82±0.34)分、(1.23±0.25)分]低于对照组[(3.18±0.45)分、(1.78±0.31)分],差异有统计学意义(P<0.05);观察组宫缩痛持续时间[(0.35±0.08)h/次]短于对照组[(0.47±0.11)h/次],发作次数[(1.15±0.26)次/天]少于对照组[(1.68±0.35)次/天],差异有统计学意义(P<0.05);两组阴道流血量、不良反应相比,均差异无统计学意义(P>0.05)。结论元胡止痛滴丸联合间苯三酚可提高顺产后宫缩痛产妇镇痛效果,减轻宫缩痛,促进产后康复,且不会增加产后出血量,安全可靠。 | 刘玉华 罗小慧 陈晴梅 | 2023 | 药品评价2023，20，5： | 0 |
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