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| 1 | 中药及其外用制剂调控细胞因子促创面愈合的研究进展显示文摘创伤、外科手术、急性疾病或慢性疾病引起的伤口延迟愈合或不愈,以及增生的瘢痕,给患者的生理健康、心理和家庭经济造成了沉重的负担。如何加速创面愈合及获得满意的美学效果是临床亟待解决的问题。创面愈合包括止血、炎症、增殖和重塑过程,该过程涉及多种细胞因子参与。近年来,中药通过调控细胞因子对加速创面愈合,抑制疤痕形成等机制得到了逐步阐明,为中药在临床创伤的疗效提供了科学依据。该文重点回顾和总结了中药有效成分、提取物及其外用制剂通过调节细胞因子在创面愈合炎症、增殖、重塑阶段发挥的治疗作用及起效机制,并对未来的研究及应用提出建议与展望,以期为中药用于加速创面愈合等研究与应用提供依据与参考。 | 杨露 张永萍 彭丽华 | 2021 | 中国中药杂志2021，46，20： | 13 |
| 2 | 糖尿病足溃疡创面愈合的现代敷料显示文摘糖尿病足溃疡(DFU)创面持续不愈合是导致糖尿病足患者截肢甚至死亡的重要原因,敷料应用是治疗DFU的关键部分。现代敷料应用于DFU创面取得了一定进展,近期较高质量证据推荐采用新的循证治疗方式,如蔗糖八硫酸盐敷料等。该文对近10年现代敷料的种类、特征和研究进展进行介绍。 | 曹瑛 林钰敏 薛耀明 | 2021 | 中华糖尿病杂志2021，13，5： | 3 |
| 3 | A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy显示文摘Liposome could form a long-term drug reservoir in the skin for sustained drug release,which is beneficial to improving efficacy and alleviating adverse effects.Thus,it has become a better option for anti-alopecia drugs delivery.However,cholesterol used as the fluidity buffer in conventional liposomes is a precursor for testosterone biosynthesis,which could convert to dihydrotestosterone,resulting in hair follicle damage and potentiating hair loss.To overcome the limitations,in this study we prepared a cholesterol-free liposome(PPD-Lip)using protopanaxadiol(PPD)instead of cholesterol to avoid the biosynthesis of testosterone which is adverse to alopecia therapy.PPD-Lip also worked as an active ingredient to facilitate hair growth by promoting dermal papilla cells proliferation and migration,upregulating mRNA levels of hair growth-related positive regulators,and accelerating angiogenesis in vitro.Meanwhile,it promoted hair regrowth in telogen and androgenetic alopecia mice models in vivo.In addition,our study showed that as the liposomal vehicle,PPD-Lip loaded with dutasteride exerted a stronger efficacy in the treatment of androgenetic alopecia and such a strategy could extend to other anti-alopecia agents.To the best of our knowledge,being easy for clinical transformation,the PPD-based liposomal delivery system provides a promising and multifunctional alternative platform for the delivery of alopecia treatment agents. | Xuefei Zhang Shuxuan Li Yating Dong Hehui Rong Junke Zhao Haiyan Hu | 2022 | Nano Research2022，15，10： | 0 |
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