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| 1 | 生物可降解医用镁合金体内外降解行为研究进展显示文摘作为新一代医用可降解生物材料,镁合金凭借其良好的生物相容性、独特的降解性、优异的力学传递性,被誉为'革命性的医用金属材料'。然而,镁合金耐蚀性能较差,存在降解过快以及降解不均匀等现象。本文从微合金化、热加工工艺、塑性变形工艺以及表面改性4种处理方式全面介绍了目前改善镁合金降解性能的研究进展,并对比了不同工艺处理方式下医用镁合金的体内外降解速率和降解模式,揭示了镁合金不同工艺处理条件下的组织演变、膜层特性对Cl~-的膜层破坏机制及三维降解形貌的影响规律,建立起在模拟液中不同工艺条件与镁合金腐蚀降解速率的关联数据分析模型,最后指出从多角度解析微观结构对镁合金降解性能的作用机制,构建微观组织对镁合金降解寿命预测模型是未来该领域的研究重点。 | 田亚强 赵冠璋 刘芸 张源 郑小平 陈连生 | 2021 | 材料工程2021，49，5： | 6 |
| 2 | 含铜钛合金调控巨噬细胞极化的研究进展显示文摘含铜钛合金作为一种新型抗菌材料,具有良好的生物学性能和机械性能,有望广泛应用于临床骨外科和口腔种植等领域。巨噬细胞是合金植入人体后介导免疫反应的主要细胞,并且直接影响合金长期服役的稳定性。含铜钛合金由于铜的添加,赋予了合金抗菌性能,一方面促进巨噬细胞吞噬和杀灭细菌,另一方面促进巨噬细胞极化激活,表达多种细胞因子,引发体内炎症反应。然而,目前关于含铜钛合金调控巨噬细胞极化的类型尚无定论,铜离子调控巨噬细胞极化的机制仍未统一。本文对已发表的关于含铜钛合金调控巨噬细胞极化的研究进行总结,分别从材料类型、表面处理、加工方式和细胞的培养方式、培养密度等方面,对相关文献进行综述,并且对医用含铜钛合金的应用进行了展望,希望通过改变含铜钛合金的性能,如加工方式或表面处理等,调控巨噬细胞的极化方向,以期为医用含铜钛合金的设计及临床应用提供参考。 | 娄静扬 耿欣荣 高慧萌 范东阳 赵昕 王强 | 2022 | 口腔疾病防治2022，30，5： | 1 |
| 3 | Biomechanical Analysis of Personalised 3D-Printed Clavicle Plates of Different Materials to Treat Midshaft Clavicle Fractures显示文摘This study was aimed at comparing the biomechanical performance of personalised 3D-printed clavicle plates of different materials to treat midshaft clavicle fractures with the finite element(FE)method.The FE model of a fractured clavicle with a personalised 3D-printed clavicle plate and screws was constructed.Three types of materials were simulated,including stainless steel,titanium alloy,and magnesium alloy.Two loading conditions(axial compression and inferior bending)were applied at the distal end of the clavicle to simulate arm abduction.Plate stiffness,peak stress,and bone strain at the clavicle fracture site were measured and compared.The stiffness of the stainless steel clavicle plate was significantly greater than that of the titanium alloy clavicle plate.The stiffness of the magnesium alloy clavicle plate was similar to that of the intact clavicle;peak stress of the magnesium alloy clavicle plate was the lowest;thus,it had less stress-shielding effects on bone formation.The magnesium alloy clavicle plate was more likely to form bone by distributing proper strain at the clavicle fracture site.According to the influence of different materials on the tensile strength,magnesium alloy clavicle plates might be preferred owing to their bionic stiffness in the treatment of patients with a low risk of falling.For patients who engage in contact sports,a titanium alloy clavicle plate might be more suitable. | 程荣山 蒋子昂 DIMITRIOU Dimitriou 龚伟华 蔡宗远 | 2021 | Journal of Shanghai Jiaotong university(Science)2021，26，3： | 0 |
| 4 | Glycerol solutions of highly concentrated biomineral counter-ions towards water-responsive mineralization: Demonstration on bacterial cellulose and its application in hard tissue repair显示文摘Mineralization has found widespread use in the fabrication of composite biomaterials for hard tissue regeneration.The current mineralization processes are mainly carried out in neutral aqueous solutions of biomineral counter-ions(a pair of cation and anion that form the corresponding minerals at certain conditions),which are stable only at very low concentrations.This typically results in inefficient mineralization and weak control over biomineral formation.Here,we find that,in the organic solvent glycerol,a variety of biomineral counter-ions(e.g.,Ca/PO_(4),Ca/CO_(3),Ca/SO_(4),Mg/PO_(4),or Fe/OH)corresponding to distinct biominerals at significantly high concentrations(up to hundreds-fold greater than those of simulated body fluid(SBF))are able to form translucent and stable solutions(mineralizing solution of highly concentrated counter-ions(MSCIs)),and mineralization can be triggered upon them with external solvents(e.g.,water or ethanol).Furthermore,with pristine bacterial cellulose(BC)membrane as a model,we demonstrate an effective and controllable mineralization performance of MSCIs on organic substrates.This approach not only forms the homogeneous biominerals on the BC fibers and in the interspaces,but also provides regulations over mineralization rate,mineral content,phase,and dopants.The resulting mineralized BC membranes(MBCs)exhibit high cytocompatibility and favor the proliferation of rat bone marrow mesenchymal stem cells(rBMSC).Following this,we prepare a mineralized bone suture(MBS)from MBC for non-weight bearing bone fixation,which then is tested on a rabbit median sternotomy model.It shows firm fixation of the rabbit sternum without causing discernible toxicity or inflammatory response.This study,by extending the mineralization to the organic solution system of highly concentrated counter-ions,develops a promising strategy to design and build targeted mineral-based composites. | Yunfei Zhao Xiaohao Liu Zhi Zhou Chaobo Feng Nan Luo Jiajun Yan Shuo Tan Yang Lu Feng Chen Bing-Qiang Lu Shisheng He | 2024 | Nano Research2024，17，3： | 0 |
| 5 | Research progress on corrosion behaviors and biocompatibility of rare-earth magnesium alloys in vivo and in vitro显示文摘As yet,Mg alloys acting as the medical implants have drawn extensive attention,due to their spontaneous degrada bility,effective load-transmissibility and the excellent biocompatibility,particularly in bone tissue reconstruction and vascular radial-support.Regrettably,they were inevitably affected by the tension/compression-torsion,dynamic erosion and corrosion fatigue under complex service conditions,which lead to premature failure of implantation-materials.Micro-alloying addition is an effective way to delay the rapid degradation,especially in rare-earth micro-composite addition.It can not only reduce intensities of galvanic-corrosion by refining the grain sizes and adjusting the Volta-potentials distribution of the precipitates,but also modify the compositions and biocompatibility of the degradation products.Moreover,the higher compress tress on the surface can improve the stability and densification of the film layer,which enhanced the corrosion resistance.Thus,the latest research progress about in vivo/vitro degradation behavio rs and bioco mpatibility of rare-earth Mg alloys is reviewed;The internal relationships between rare-earth elements,phase features and degradation behaviors of Mg alloys are summarized.Moreover,the effects of rare-earth addition on the film-characteristics are deeply explained,and the induced mechanisms of rare earth elements on the biocompatibility are revealed. | Yuan Zhang Yun Liu Ruining Zheng Yaqi Zheng Liansheng Chen | 2023 | Journal of Rare Earths2023，41，12： | 0 |
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