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| 1 | 干细胞-3D支架复合物在伤口敷料中的应用显示文摘大面积创伤或难治性创面的临床治疗十分棘手,寻找合适的伤口敷料对伤口愈合十分重要。干细胞可分泌表达伤口愈合所必需的多种细胞因子,并能在三维(3D)支架材料中较长时间地生长增殖,维持其应有的结构和功能。将干细胞-3D支架复合物以湿润的敷料形式移植于皮肤创面,可显著提高干细胞移植效率,缩短伤口愈合时间,并能减轻瘢痕形成。干细胞-支架复合物或许可成为良好的伤口敷料。该文主要就伤口敷料的选择及干细胞-3D支架复合物作为伤口敷料的研究现状进行综述,旨在为干细胞-3D支架复合物的临床应用提供依据。 | 刘凤琴 王淞 | 2021 | 国际外科学杂志2021，48，5： | 1 |
| 2 | 肝样细胞模型在药物性肝损伤研究中的进展显示文摘肝样细胞由胚胎干细胞、诱导多能干细胞、外周血单核细胞或其他成体细胞等非肝脏来源的细胞在不同诱导培养条件下逐步分化而成,其形态类似于原代肝细胞,具备合成、摄取、分泌和药物代谢等功能,是体外预测和评估药物性肝损伤的理想细胞模型。不同来源的肝样细胞在研究药物代谢和毒性方面各有优缺点,改进诱导策略和培养体系有助于获得功能更加成熟的肝样细胞。 | 高广周 陈思文 万军 | 2022 | 中华消化杂志2022，42，1： | 1 |
| 3 | Induced pluripotent stem cells as an innovative model to study drug induced pancreatitis显示文摘Drug-induced pancreatitis is a gastrointestinal adverse effect concerning about 2%of drugs.The majority of cases are mild to moderate but severe episodes can also occur,leading to hospitalization or even death.Unfortunately,the mechanisms of this adverse reaction are still not clear,hindering its prevention,and the majority of data available of this potentially life-threatening adverse effect are limited to case reports leading to a probable underestimation of this event.In particular,in this editorial,special attention is given to thiopurine-induced pancreatitis(TIP),an idiosyncratic adverse reaction affecting around 5%of inflammatory bowel disease(IBD)patients taking thiopurines as immunosuppressants,with a higher incidence in the pediatric population.Validated biomarkers are not available to assist clinicians in the prevention of TIP,also because of the inaccessibility of the pancreatic tissue,which limits the possibility to perform dedicated cellular and molecular studies.In this regard,induced pluripotent stem cells(iPSCs)and the exocrine pancreatic differentiated counterpart could be a great tool to investigate the cellular and molecular mechanisms underlying the development of this undesirable event.This particular type of stem cells is obtained by reprogramming adult cells,including fibroblasts and leukocytes,with a set of transcription factors known as the Yamanaka’s factors.Maintaining unaltered the donors’genetic heritage,iPSCs represent an innovative model to study the mechanisms of adverse drug reactions in individual patients’tissues not easily obtainable from human probands.Indeed,iPSCs can differentiate under adequate stimuli into almost any somatic lineage,opening a new world of opportunities for researchers.Several works are already available in the literature studying liver,central nervous system and cardiac cells derived from iPSCs and adverse drug effects.However,to our knowledge no studies have been performed on exocrine pancreas differentiated from iPSCs and drug-induced pancreatitis,so far.Hence,in this editorial we focus specifically on the description of the study of the mechanisms of TIP by using IBD patient-specific iPSCs and exocrine pancreatic differentiated cells as innovative in vitro models. | Elena Genova Gabriele Stocco Giuliana Decorti | 2021 | World Journal of Gastroenterology2021，27，35： | 0 |
| 4 | 组织工程与修复重建技术在小儿外科的应用进展显示文摘儿童创伤、畸形、肿瘤、炎症等疾病可导致组织缺损,给组织工程与修复重建外科带来新的挑战。在过去30年里,组织工程与修复重建技术在小儿外科领域得到了长足发展。组织工程在皮肤、骨与软骨、肌腱、血管、肝脏、肾脏、膀胱、神经等领域应用广泛,相关器官的修复重建领域也有新的研究进展。各种新技术在种子细胞、生物材料和组织构建中的应用是组织工程与修复重建发展的基础,但应用到儿童群体,需要考虑其特殊性,如持续生长发育、免疫器官的逐步成熟、重建组织的再血管化及如何达到功能重建等。此外,有关组织工程与修复重建的伦理学问题也亟需解决。本文将介绍组织工程与修复重建技术在小儿外科领域的应用进展。 | 赵卫华 朱光辉 | 2020 | 临床小儿外科杂志2020，19，11： | 0 |
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