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| 1 | 基于亚甲基蓝制备的抗还原、抗聚集和抗DNA干扰的光动力治疗碳点显示文摘光动力疗法(PDT)是一种重要的癌症治疗手段,亚甲基蓝(MB)作为一种有效的光敏剂被广泛应用于光动力治疗.然而,MB在体内由于聚集以及与DNA结合而导致减色效应.同时,MB在实体瘤的低氧环境中容易被还原为无色的还原态leucoMB,从而丧失光动力能力.因此,我们以MB作为碳源,制备碳点MB-CDs.MBCDs不仅继承了MB的PDT能力,而且表现出良好的生物相容性和低毒性.重要的是,MB-CDs具有出色的抗还原、抗聚集和抗DNA干扰的能力,并且MB-CDs在体外和体内均表现出良好的PDT活性,仅用590 nm LED光源照射一次,即可使肿瘤体积减小到原始体积的20%以下. | 徐宁 谷泉泳 杜健军 葛浩英 龙飒然 孙文 樊江莉 彭孝军 | 2021 | Science China Materials2021，64，9： | 2 |
| 2 | Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications显示文摘Carbon dots(CDs)have become popular nanomaterials in biomedical and agricultural fields.Herein we synthesized multifunctional CDs which showed anti-cancer and anti-fungal activities.The low cytotoxicity,stable fluorescence and high photothermal conversion efficiency enable the CDs with imagingguided photothermal therapy.The CDs also exhibited intrinsic anti-fungal activity even at a low concentration,i.e.,40 mg·L^(-1) of CDs induced 20%mortality in cucumber downy mildew.Moreover,the largeπ-conjugated nanostructure and the richness of amino and hydroxyl groups make them a powerful delivery platform for flumorph(a fungicide)with a high loading efficiency of 47.18%.Meanwhile,the heat converted from the light can accelerate the release of flumorph from CDs,and thus efficiently kill fungus. | Shaojing Zhao Li Huang Yong Xie Bin Wang Feng Wang Minhuan Lan | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
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