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| 1 | 无患子属植物的化学成分及生物活性研究进展显示文摘本文对近30年来无患子属植物的化学成分和生物活性研究进展进行了综述,为该属植物的进一步开发利用提供参考。无患子属植物的化学成分主要包括挥发油、三萜皂苷、倍半萜苷类化合物等,这些化合物具有抑菌、抗肿瘤、保肝和表面活性等多方面的生物活性。 | 徐凯节 次旦扎西 丁立生 | 2013 | 天然产物研究与开发2013，25，2： | 26 |
| 2 | 不同种源无患子的种子品质差异分析显示文摘用与重庆市毗邻的四川和云南的5个地方即会理、仁和、盐边、大姚以及永仁的无患子作为供试材料,研究了它们间的种子品质差异.试验结果表明:四川会理种源在无患子皂苷含量、皂苷纯度、种子质量以及生长等测定指标上均极显著地优于其它种源,性状表现最为卓越,可作为重庆市的备选优良种源. | 辜夕容 | 2009 | 西南大学学报(自然科学版)2009，31，6： | 18 |
| 3 | 无患子三萜皂苷研究进展显示文摘无患子是一种集工业、药用、观赏、生态于一体的多功能综合利用价值极高的经济树种,近年来,由于其具有较高的商业价值和药理活性,受到了广泛的重视。迄今文献中报道的无患子中分离鉴定的三萜皂苷类化合物有71种,具有抗菌、抗肿瘤、保护心脑血管、保护肝脏、抗生育、杀虫等多种生物活性和良好的非离子表面活性作用,在医药、食品保健、日化和农业等领域应用前景广阔。本文对其皂苷的种类、提取与分离及其应用进行了综述,以期为今后无患子的研究、开发与利用提供参考。 | 徐圆圆 贾黎明 陈仲 高媛 | 2018 | 化学通报2018，81，12： | 15 |
| 4 | 无患子皂苷的提取、类型及药理活性显示文摘无患子是重要的资源植物,其含有丰富的皂苷种类和多样化的药理活性。本文概述了无患子皂苷的提取介质、提取条件和提取效果;综述了其皂苷的结构类型,侧链种类、连接部位、连接方式和产生的植体部位,以及抗菌、灭螺、杀虫、消炎、抗肿瘤、保肝、杀精活性,为无患子皂苷的深入研究和开发奠定基础。 | 李芳 霍光华 叶亚建 陈明辉 | 2012 | 天然产物研究与开发2012，24，B12： | 8 |
| 5 | 无患子皂苷生物活性及应用研究进展显示文摘本文综述了无患子皂苷生物活性和在医药、日化、农业领域应用研究进展,为综合开发利用无患子这一古老而传统的药用植物提供科学依据。 | 唐青涛 马忠华 黄苑玲 翟旭峰 廖伟玲 黄泽华 | 2007 | 天然产物研究与开发2007，19，B11： | 7 |
| 6 | 锌-α_2-糖蛋白(ZAG)在雄性大鼠生殖系统中表达差异的研究显示文摘目的探讨(研究)锌-α 2-糖蛋白(ZAG)在成年雄性SD大鼠生殖系统中的表达情况。方法应用商品化试剂盒分别抽提RNA和蛋白质,利用实时荧光定量PCR(Realtime PCR)和免疫印迹(Westernblot)的方法研究ZAG在SD大鼠生殖系统各器官中的表达情况。结果雄性SD大鼠生殖系统各器官中均有ZAG蛋白的存在,不同组织表达有一定的差异,尤其是在尾部附睾及附睾脂肪组织中表达较高,其它组织相对较低。结论大鼠生殖系统中ZAG主要分布在尾部附睾及附睾脂肪组织。通过对ZAG蛋白在雄性SD大鼠生殖系统表达差异的研究,有助于进一步了解该蛋白在雄性生殖系统中的生物学功能。 | 赵文珍 刘悦 冯京生 丁之德 | 2010 | 中国男科学杂志2010，24，1： | 5 |
| 7 | 体质量指数与精液常规参数及精浆中ZAG含量的相关性研究显示文摘目的分析体质量指数(BMI)对精液常规参数及精浆中锌-α2-糖蛋白(ZAG)水平的影响。方法收集2015年1月至2016年12月在该院人类精子库捐精的志愿者共154例为研究对象。依据BMI,分为正常组[BMI:(21.06±1.07)kg/m2]60例、超重组[BMI:(23.84±0.60)kg/m2]41例及肥胖组[BMI:(26.57±1.78)kg/m2]53例,同时采集血液和精液。精液常规分析后,分离精浆,运用酶联免疫吸附试验(ELISA)分别进行精浆、血浆ZAG水平的检测。结果与正常组比较,肥胖组精子前向运动百分率(PR)和精浆ZAG水平均性降低(P<0.05)。各组精液体积、精子浓度差异无统计学意义(P>0.05),PR、精浆ZAG水平差异有统计学意义(P<0.05)。此外,PR与BMI呈负相关(r=-0.325,P<0.01),精浆ZAG与BMI呈负相关(r=-0.165,P<0.05),PR与精浆ZAG水平呈正相关(r=0.320,P<0.01)。结论 BMI增加导致的精子活力降低可能与精浆ZAG水平下降有关,推测精浆中ZAG水平可作为肥胖/超重患者精液活动力的有效参考指标。 | 黄静 万凌 孙大光 杨继高 计垣 陈玲 王红 周小燕 | 2018 | 重庆医学2018，47，13： | 4 |
| 8 | Antifertility effect of ethanolic extract of Amalakyadi churna in male albino mice显示文摘Aim: To evaluate the antifertility activity of the ethanolic extract of Amalakyadi churna by oral administra-tion in male albino mice. Methods: The ethanol extract of Amalakyadi churna at the dose of 250 mg/kg and 400 mg/kg body weight was administered orally for 30 days to adult male mice. On day 31, the mice were sacrificed and the testis and accessory reproductive organs were removed and weighed. The organs were processed for biochemical estimation and histological work. Results: Treatment with Amalakyadi chuma resulted in decrease in the weights of testis and accessory reproductive organs. The diameters of testis, seminiferous tubules and Leydig cell nucleus were decreased. The spermatogenic elements, like spermatogonia, spermatocytes and spermatids in the testis were re-duced significantly as well as the sperm count in cauda epididymis. There was a significant reduction in the protein,glycogen, DNA and RNA contents and the activity of acid phosphatase in the testis of extract treated mice compared with the control. The cholesterol content and the alkaline phophatase activity were increased significantly in treated mice. Conclusion: Amalakyadi churna extract arrests spermatogenesis in male mice without noticeable side effects.(Asian J Andro12003 Sep; 5: 247-250) | Y.N.Seetharam H.Sujeeth G.Jyothishwaran Arvind Barad G.Sharanabasappa B.Umareddy M.B.Vijaykumar Saraswati B.Patil | 2003 | Asian Journal of Andrology2003，5，3： | 3 |
| 9 | Effect of Semecarpus anacardium fruits on reproductive function of male albino rats显示文摘Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·kg^-l·day^-1, 200 mg·kg^-l·day^-1 and 300 mg·kg^-1·day^-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. Thes perm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids.The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion:S. anacardium fruit extract causes spermatogenic arrest in albino rats. ( Asian J Androl 2003 Jun; 5: 121-124) | Arti Sharma Pramod Kumar Verma V.P.Dixit | 2003 | Asian Journal of Andrology2003，5，2： | 3 |
| 10 | 锌-α2-糖蛋白(ZAG)在SD大鼠附睾管中表达的研究显示文摘目的:探讨锌-α2-糖蛋白(ZAG)在成年雄性SD大鼠附睾管中的表达情况。方法:分别抽提附睾头、体、尾部精子和附睾液中的蛋白质,利用免疫印迹的方法研究ZAG在SD大鼠附睾管各段中的表达情况。结果:附睾头、体、尾部中的精子和附睾液中均有ZAG蛋白的存在,表达有一定的差异,附睾头部至尾部中的精子和附睾液表达逐渐增加。结论:ZAG主要分布在附睾尾部的精子和进一步的附睾液中,为后续的功能研究奠定了必要的基础。 | 赵文珍 何颖红 杨勇琴 王云涛 | 2014 | 中国社区医师(医学专业)2014，16，13： | 2 |
| 11 | Effect of Stephania hernandifolia leaf extract on testicular activity in rats显示文摘Aim: The testicular inhibitory effect of the aqueous fraction of methanol extract of Stephania hernandifolia leaf was studied in male Wistar rats. Methods: The supernatent and the precipitate part of aqueous fractions of the methanol extract of the leaf were gavaged separately to rat at a similar dose of 200 mg/mL per 100 g body weight per day for 28 days. After cessation of treatment, various observations were conducted. Results: In both treated groups, there were significant decreases in the relative weights of the sex organs, the testicular key androgenic enzymes activities, the plasma level of testosterone, the number of different germ cells at stage VII of seminiferous epithelial cell cycle and the seminiferous tubular diameter in comparison to the controls. Neither of the parts had somatic, renal and hepatic toxicity. This study suggested that the active molecules present in the aqueous fraction of methanol extract of Stephania hernandifolia leaves might be steroids as indicated by thin layer chromatography using specific staining substance for steroid molecules. Conclusion: In rats, the aqueous fraction of methanol extract of the S. hernandifolia leaves possesses certain testis-inhibitory substances, which may be steroid-like agents. ( Asian J Androl 2003 Jun; 5:125-129 ) | D.Jana R.Maiti D.Ghosh | 2003 | Asian Journal of Andrology2003，5，2： | 2 |
| 12 | Clinical trial of Butea superba, an alternative herbal treatmentfor erectile dysfunction显示文摘Aim: To study the effect of Butea superba on erectile dysfunction (ED) in Thai males. Methods: A 3-month randomized double-blind clinical trial was carried out in volunteers with ED, aged 30 years-70 years, to evaluate the therapeutic effect of the crude preparation of Butea superba tubers on ED. Results: There was a significant upgrading in 4 of the 5 descriptive evaluations of the IIEF-5 questionnaire. Estimation of the sexual record indicated that 82.4 % of the patients exhibited noticeable improvement. Haematology and blood chemistry analysis revealed no apparent change. Conclusion: The plant preparation appears to improve the erectile function in ED patients without apparent toxicity. ( Asian J Andro12003 Sep; 5: 243-246) | W.Cherdshewasart N.Nimsakul | 2003 | Asian Journal of Andrology2003，5，3： | 2 |
| 13 | Antispermatogenic and hormonal effects of Crotalaria junceaLinn. seed extracts in male mice显示文摘Aim:To evaluate the antifertility activity of various extracts of Crotalaria juncea seeds in male mice.Methods:Adult male mice were gavaged the petroleum ether,benzene and ethanol extracts of C.juncea seeds,25mg.(100g)^-1·day1 for 30 days.On day 31 the animals were sacrificed by cervical dislocation and the testes,epididymis,vas deferens,seminal vesicles,prostate gland,bulbourethral gland and levator ani were dissected out and weighed.The organs were processed for biochemical and histological examination.Results:In petroleum ether,benzene and ethanol extracts treated rats,there was a decrease in the weights of testis and accessory reproductive organs.The diameters of the testis and seminiferous tubules were decreased.Spermatogonia,spermatocytes and spermatids in the testis and the sperm count in cauda epididymis were also decreased. There was a significant reduction in the protein and glycogen contents and an increase in the cholesterol content in the testis,epididymis and vas deferens.Of the 3 extracts,the ethanol extract appeared to be the most potent in antispermatogenic activity.When the ethanol extract was tested in immature male mice,there was an antiandrogenic effect as the weights of accessory organs were reduced.Conclusion:The various extracts of C.juncea seeds arrest spermatogenesis and are likely to have an antiandrogenic activity.(Asian J Androl 2004 Mar,6:67-70) | B. Vijaykumar I. Sangamma A. Sharanabasappa Saraswati B. Patil | 2004 | Asian Journal of Andrology2004，6，1： | 1 |
| 14 | 浸种处理下无患子苗期生长差异分析显示文摘以普通母树上采摘的无患子种子为试验材料,对其进行9种不同的浸种处理,即不同温度的温水(40℃、50℃、60℃)、不同浓度CuSO_4+H_2SO_4(20%、30%、40%)溶液和HCl溶液(3%、5%、8%),探讨不同浸种方式和水平对无患子幼苗生长的影响。结果表明:温水浸种处理下无患子幼苗的生长表现较好,40℃温水浸种明显提高幼苗苗高的生长,50℃浸种处理次之;60℃温水浸种处理对提高无患子幼苗地径生长速度在9组浸种处理中表现效果最为良好;CuSO_4+H_2SO_4溶液和HCl溶液对无患子的苗期生长影响差异显著。综合比较,温水是促进无患子幼苗生长的最佳浸种处理方法。 | 余建友 | 2016 | 南方林业科学2016，44，6： | 1 |
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