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1The [4+2] Cycloaddition of 2-Pyrone in Total Synthesis显示文摘Diels-Alder reaction is one of the most important reactions in organic synthesis and has witnessed great achievements in total syntheses of complex natural products.In this review,we will focus on the [4+2] cycloaddition that utilizes 2-pyrone as the diene component.Major advances of its applications in the total syntheses of natural products in the past fifty years will be discussed here.Quan Cai 2019Chinese Journal of Chemistry2019,37,9:3
2Rapid Access to Oxabicyclo[2.2.2 ]octane Skeleton through Cu(I)- Catalyzed Generation and Trapping of Vinyl-o-quinodimethanes (Vinyl-0-QDMs)显示文摘Summary of main observation and conclusion A Cu(I)-catalyzed three-component reaction of terminal enynals/enynones,diazo compounds,and al kenes has been developed.With this method,a series of oxabicyclo[2.2.2]octanes were effectively synthesized in high yields under mild reaction condi-tions.This transformation is proposed to proceed through trapping of the cyclic vinyl-o-quinodimethanes(vinyI-o-QDMs)species,which were generated from terminal enynals/enynones and diazo compounds by alkenes.The obvious advantages of wide substrate scopes,mild reaction conditions,and high seteroselectivity and atom eficiency make this reaction highly appealing for construction of highly rigid[2.2.2]octane skeleton.Hejiang Luo Chuan He Huanfeng Jiang Shifa Zhu 2020Chinese Journal of Chemistry2020,38,10:0
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