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| 1 | FoxM1 affects adhesive,migratory,and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2显示文摘Forkhead box protein M1(FoxM1)is an important transcription factor involved in various pathological processes including tumor metastasis.The changes of adhesive,migratory,and invasive abilities are considered as crucial events in tumor metastasis progression.In this study,we aimed to investigate the correlation between FoxM1 and retinoblastoma(Rb)metastasis and to explore the detailed mechanism.Wound healing,cell adhesion,and invasion assays showed that FoxM1 overexpression induced epithelial-mesenchymal transition in Y-79 cells and inhibited adhesion and subsequently promoted metastasis of Y-79 cells,while FoxM1 knockdown showed the opposite effects.A luciferase reporter assay and chromatin immunoprecipitation assay provided evidence that FoxM1 promoted matrix metalloproteinase 2(MMP2)transcription by directly binding to and promoting MMP2 promoter.MMP2 knockdown by siRNA transfection attenuated cell metastasis of Y-79 cells induced by FoxM1 overexpression.Furthermore,the FoxM1-binding site mapped between-1167 and-1161 bp of the MMP2 promoter was identified.Our results suggested that the FoxM1-MMP2 axis plays an important role in Rb metastasis,which may be a novel target for designing therapeutic regimen to control Rb metastasis. | Xue Zhu Mengxi Yu Ke Wang Wenjun Zou Ling Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 1 |
| 2 | 膀胱癌患者癌组织ABCC4、miR506-3-p表达水平及临床意义显示文摘目的检测膀胱癌患者ATP结合盒转运蛋白C4(ABCC4)和微小RNA-506-3p(miR-506-3p)的表达水平,并探讨其与患者预后的关系。方法选取2015年5月至2017年5月该院收治的78例膀胱癌患者作为研究对象,术中收集所有患者膀胱癌组织及癌旁组织(距离癌组织边缘≥3 cm)。采用免疫印迹法或实时荧光定量PCR技术检测各组织ABCC4蛋白、mRNA及miR-506-3p的表达水平,分析ABCC4蛋白和miR-506-3p表达的相关性、靶向调控关系,以及二者与膀胱癌患者临床病理特征、术后4年总生存率的关系;COX回归分析影响膀胱癌患者预后的危险因素。结果膀胱癌组织ABCC4蛋白和mRNA的表达水平均明显高于癌旁组织(P<0.05),而膀胱癌组织miR-506-3p的表达水平明显低于癌旁组织(P<0.05)。膀胱癌组织中ABCC4蛋白与miR-506-3p表达呈负相关(P<0.05),且miR-506-3p可靶向调控ABCC4;膀胱癌组织ABCC4蛋白的表达水平与肿瘤分期、肿瘤最大径和是否发生淋巴结转移有关(P<0.05),miR-506-3p表达水平与肿瘤分期有关(P<0.05)。ABCC4蛋白高表达组患者总生存率明显低于低表达组(P<0.05),miR-506-5p高表达组总生存率明显高于低表达组(P<0.05);肿瘤分期及膀胱癌组织ABCC4蛋白、miR-506-3p表达是影响膀胱癌患者预后的独立危险因素(P<0.05)。结论ABCC4在膀胱癌组织中表达上调,而miR-506-3p在膀胱癌组织中表达下调,且二者呈负相关。ABCC4、miR-506-3p均具有作为膀胱癌预后标志物和治疗靶点的潜力。 | 廖高源 何超 刘攀 | 2023 | 国际检验医学杂志2023，44，20： | 0 |
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