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| 1 | Importance of incorporating systemic cerebroarterial hemodynamics into computational modeling of blood flow in intracranial aneurysm显示文摘The importance of properly treating boundary conditions (BCs) in numerical simulation of hemodynamics in intracranial aneurysm (IA) has been increasingly recognized. In this study, we constructed three types of computational model for each IA to investigate how the outcome of numerical simulation is affected by the treatment of BCs. The first type of model (i.e., Type-A model) was obtained by applying 3-D hemodynamic modeling to the entire cerebral arterial network, with its solution being taken as the reference for evaluating the performance of the other two types of model (i.e., Type-B and Type-C models) in which 3-D modeling was confined to the aneurysm region. In addition, patient-specific 1-D models of the cerebral arterial network were developed to provide hemodynamic information for setting the inflow/outflow BCs of the 3-D models. Numerical tests on three IAs revealed that prescribing the outflow BCs of a localized 3-D aneurysm model based on 1-D model-simulated outflow division (i.e., Type-B model) instead of imposing the free outflow BC on all outlets (i.e., Type-C model) helped to improve the fidelity of the simulation of intra-aneurysmal hemodynamics, but could not guarantee a complete reproduction of the reference solution obtained by the Type-A model. Moreover, it was found that the outcome of hemodynamic simulation was more sensitive to the treatment of BCs when an aneurysm was located at arterial bifurcation rather than sidewall. These findings highlight the importance of taking into account systemic cerebroarterial hemodynamics in computational modeling of hemodynamics in IAs, especially those located at bifurcations. | Zhi-qiang Zhang Li-jian Xu Rong Liu Xiao-sheng Liu Bing-Zhao Fu-you Liang | 2020 | Journal of Hydrodynamics2020，32，3： | 3 |
| 2 | Evaluation of the hemolysis and fluid dynamics of a ventricular assist device under the pulsatile flow condition显示文摘When the rotary blood pumps are used as ventricular assist devices,the pump flow rate will have a pulsatile component even at a constant impeller rotational speed due to the remaining beating of the natural heart.However,previous studies on the in vitro hemolysis evaluation of a rotary blood pump have always been conducted under steady states and this pulsation was not taken into account.In this study,the hemolysis in a centrifugal blood pump is evaluated under the pulsatile flow condition in vitro.The required time-varying flow rate is obtained by conducting a system simulation of the pump-assisted cardiovascular system,and realized by controlling a pulsation unit in the experiments.The results of our tests indicate a significant increase in hemolysis under the pulsatile flow condition compared with the non-pulsatile condition.To reveal the flow characteristics responsible for the higher hemolysis,transient computational fluid dynamic simulations are then performed.This study suggests that traditional hemolysis evaluation under the steady states may not fully represent the hemolytic performance in the clinical use.For the ventricular assist pumps at the design stage,eliminating the concern about the extra hemolysis under the pulsatile condition will be helpful for the subsequent in vivo experiments. | Huan Li Zhe Gou Feng Huang Xiao-dong Ruan Wen-wei Qian Xin Fu | 2019 | Journal of Hydrodynamics2019，31，5： | 1 |
| 3 | 中孕期胎儿鼻骨回声缺失及发育不良在染色体异常筛查方面的临床应用显示文摘目的:探析中孕期胎儿鼻骨回声缺失及发育不良在染色体异常筛查方面的临床效果及其价值。方法:回顾分析本院于2017年1月~2019年1月行超声检出的60例中孕期鼻骨回声缺失及发育不良胎儿的临床资料,分析胎儿鼻骨回声缺失与发育不良的染色体异常检出结果及其超声图像特征。结果:13例鼻骨发育异常合并结构畸形,9例染色体异常;15例鼻骨发育异常合并其他超声软指标阳性,5例染色体异常;32例单纯鼻骨发育异常胎儿,1例21-三体染色体异常。10例21-三体胎儿中,3例发育不良,7例双侧鼻骨缺失。结论:中孕期胎儿鼻骨回声缺失及发育异常是检出染色体异常的重要参考依据,联合检测结构畸形、超声软指标等可进一步提高产前胎儿染色体异常的筛查率,有助于避免21-三体综合征或其他染色体异常胎儿出生。 | 赵冬冰 | 2021 | 中国医疗器械信息2021，27，14： | 0 |
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