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| 1 | AAV9-Jumonji对慢性心力衰竭犬心脏肾素-血管紧张素-醛固酮系统活性的影响显示文摘目的:观察AAV9-Jumonji对慢性心力衰竭犬心脏,肾素-血管紧张素-醛固酮系统(RAAS)活性的影响,探讨其改善慢性心力衰竭的作用机制。方法:以杂种犬为研究对象,随机分为对照(control)组,心力衰竭(CHF)组,AAV9-Jumonji+心力衰竭(AAV9-Jumonji+CHF)组;超声心动图检查平均动脉压(mean artery pressure,MAP)和LVEF变化;酶联免疫法检测各组犬血清中ACE2、Ang II和collagen I的含量;q PCR和Western blot法检测各组犬心室肌组织中ACE2、Ang II和collagen I mRNA和蛋白的表达。结果:CHF造模后(第28天),与control组比较,CHF组与AAV9-Jumonji+CHF组MAP和LVEF明显降低(P<0.05);注射AAV9-Jumonji 14 d后(第42天),与control组比较,CHF组MAP和LVEF明显降低(P<0.05),与CHF组比较,AAV9-Jumonji+CHF组MAP和LVEF明显升高(P<0.05);与control组比较,CHF组犬血清中AngⅡ和collagen I含量均升高(P<0.05),ACE2含量降低(P<0.05);与CHF组比较,AAV9-Jumonji+CHF组犬血清中AngⅡ和collagen I含量均降低(P<0.05),ACE2含量升高(P<0.05);与control组比较,CHF组犬心室肌中AngⅡ和collagen I mRNA和蛋白表达均上调(P<0.01),ACE2 mRNA和蛋白表达下调(P<0.01);与CHF组比较,AAV9-Jumonji+CHF组犬心室肌中AngⅡ和collagen I mRNA和蛋白表达均下调(P<0.05),ACE2 mRNA和蛋白表达上调(P<0.05)。结论AAV9-Jumonji抑制慢性心力衰竭犬心脏RAAS活性的增强,从而显著改善慢性心力衰竭犬心功能。 | 吴雷琪 李鸣远 阿里旦·艾尔肯 孙娟 | 2019 | 心肺血管病杂志2019，38，12： | 1 |
| 2 | JMJD family proteins in cancer and inflammation显示文摘The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth.It is believed that various factors collectively contribute to cancer,and there is no one single explanation for tumorigenesis.Epigenetic changes such as the dysregulation of enzymes modifying DNA or histones are actively involved in oncogenesis and inflammatory response.The methylation of lysine residues on histone proteins represents a class of post-translational modifications.The human Jumonji C domain-containing(JMJD)protein family consists of more than 30 members.The JMJD proteins have long been identified with histone lysine demethylases(KDM)and histone arginine demethylases activities and thus could function as epigenetic modulators in physiological processes and diseases.Importantly,growing evidence has demonstrated the aberrant expression of JMJD proteins in cancer and inflammatory diseases,which might serve as an underlying mechanism for the initiation and progression of such diseases.Here,we discuss the role of key JMJD proteins in cancer and inflammation,including the intensively studied histone lysine demethylases,as well as the understudied group of JMJD members.In particular,we focused on epigenetic changes induced by each JMJD member and summarized recent research progress evaluating their therapeutic potential for the treatment of cancer and inflammatory diseases. | Wang Manni Xue Jianxin Hong Weiqi Chen Siyuan Shi Huashan | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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