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| 1 | Biomarkers vs imaging in the early detection of hepatocellular carcinoma and prognosis显示文摘Hepatocellular carcinoma (HCC) is the 5th most frequently diagnosed cancer in the world, according to the World Health Organization. The incidence of HCC is between 3/100000 and 78.1/100000, with a high incidence reported in areas with viral hepatitis B and hepatitis C, thus affecting Asia and Africa predominantly. Several international clinical guidelines address HCC diagnosis and are structured according to the geographical area involved. All of these clinical guidelines, however, share a foundation of diagnosis by ultrasound surveillance and contrast imaging techniques, particularly computed tomography, magnetic resonance imaging, and sometimes contrast-enhanced ultrasound. The primary objective of this review was to systematically summarize the recent published studies on the clinical utility of serum biomarkers in the early diagnosis of HCC and for the prognosis of this disease. | Lavinia Alice Balaceanu | 2019 | World Journal of Clinical Cases2019，7，12： | 7 |
| 2 | 二维剪切波弹性成像联合血清学指标对原发性肝细胞癌切除术后短期复发的预测价值显示文摘目的观察二维剪切波弹性成像(2D-SWE)联合血清学指标对原发性肝细胞癌(HCC)切除术后短期复发的预测价值。方法回顾性分析2019年4月至2021年6月在皖南医学院弋矶山医院收治的94例HCC切除术患者为研究对象(观察组),另同期选择健康体检者的33例为对照组。检测患者2D-SWE值、血清肝纤维化4因子指数(FIB-4)、血小板计数(PLT)、丙氨酸氨基转移酶(ALT)以及谷草转氨酶(AST),并计算天门冬氨酸氨基转移酶/血小板比值指数(APRI)值、谷丙转氨酶-血小板比值指数(BPRI),对比两组患者2D-SWE、BPRI、FIB-4以及APRI表达水平,根据94例原发性肝细胞癌患者切除术后3个月内复发情况将其分为复发组(23例)和非复发组(71例),采用相关性分析2D-SWE值、BPRI、FIB-4以及APRI表达水平与患者术后短期复发的相关性,采用ROC曲线下面积(AUC)评估上述指标联合检测对HCC切除术患者复发的诊断效能。结果两组患者年龄、性别、居住地、BMI、文化程度、吸烟史、饮酒史、高血压、糖尿病史、高血脂等一般资料对比差异无统计学意义(P>0.05);观察组患者2D-SWE值低于对照组,而BPRI、FIB-4以及APRI表达水平高于对照组(P<0.05);复发组患者2D-SWE值低于非复发组,而BPRI、FIB-4以及APRI表达水平高于非复发组(P<0.05);2D-SWE值与HCC患者术后3个月内复发呈负相关(r=-0.386,P<0.001),BPRI、FIB-4以及APRI与HCC患者术后3个月内复发呈正相关(分别为r=0.609,P<0.001;r=0.459,P<0.001;r=0.622,P<0.001);2D-SWE联合BPRI、FIB-4以及APRI对HCC患者术后3个月内AUC高于单独检测。结论2D-SWE联合BPRI、FIB-4以及APRI与HCC患者术后3个月内复发呈正相关,各指标均对HCC患者术后复发具有较好的诊断效能,且4种指标联合检测的效能优于单个指标检测。 | 方云艳 | 2022 | 右江民族医学院学报2022，44，6： | 0 |
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