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| 1 | An Intramolecular Charge Transfer and Aggregation Induced Emission Enhancement Fluorescent Probe Based on 2-Phenyl-1,2,3-triazole for Highly Selective and Sensitive Detection of Homocysteine and Its Application in Living Cells显示文摘Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application potentiality.What's more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/glutathione.The detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 min.APTC has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for Hcy.Finally,the mechanism was studied using 1H NMR titration experiments and mass spectrometry. | Yicheng Chu Zhengfeng Xie Daijiao Zhuang Yongshuang Yue Yuhua Yue Wei Shi Shun Feng | 2019 | Chinese Journal of Chemistry2019，37，12： | 5 |
| 2 | Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells显示文摘Cyclooxygenase-2(COX-2)has been used as an excellent traceable biomarker,and exists maximally in Golgi apparatus(Cancer cells).Celecoxib(CCB)is a selective inhibitor for COX-2,and has been used as one of non-steroidal anti-inflammatory drug.Herein we report the conjugation of nile blue(NB)with CCB via a six-carbon linkage to form a fluorescence probe NB-C6-CCB for the detection of COX-2.NB-C6-CCB displays strong fluorescence with the emission peak centered at near-infrared wavelength(700 nm)in tumor cells or tumor tissues with high expression of COX-2.Importantly,NB-C6-CCB can discriminate cancer cells(MCF-7)fluorescence intensity from normal ones(COS-7)in the co-culture medium under confocal microscope.Subcellular localization of the NBC6-CCB preferentially points to the Golgi apparatus and increases the fluorescent intensity.The competitive analysis(with CCB)and Native-PAGE analysis confirmed that NB-C6-CCB shows selective binding affinity towards COX-2 enzyme.Competitive analysis with CCB(flow cytometry assay)revealed the fluorescence intensity fluctuation due to pretreatment of CCB with different concentrations,indicating that the NB-C6-CCB is a precise or sensitive probe for the COX-2.Tumor tissue(depth:500μm),organs and mice imaging tests show excellent nearinfrared visualization,specific localization and identification of tumors. | Bhaskar Gurram Miao Li Jiangli Fan Jingyun Wang Xiaojun Peng | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 1 |
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