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1Ullmann-Ma Reaction:Development,Scope and Applications in Organic Synthesis显示文摘Copper-catalyzed cross-couplings of aryl halides and nucleophiles,traditionally called Ullmann-type coupling reactions,were initially reported by Ullmann et al.from 1901-1929.A seminal report in 1998 by Ma et al.from Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences revealed an accelerating effect caused by amino acids,which brought Ullmann-type coupling reactions into a ligand-accelerating era.From 1999 to the first 10 years of 2000s,the first-generation ligands were developed by many researchers and promoted Ullmann-type coupling reactions of aryl iodides and bromides under relatively mild conditions.Amino acid ligands,developed by Ma and coworkers,are one class of the most important first-generation ligands.In the second 10 years of 2000s,Ma et al.led the discovery of second-generation ligands for copper-catalyzed cross-coupling reactions.Two great breakthroughs have been realized by using second-generation oxalic diamide and related amide ligands,with aryl chlorides as general coupling partner and with low catalyst loadings.Now copper-catalyzed cross coupling reactions of aryl halides and nucleophiles with amino acids or oxalic diamides and related amides as ligands are recognized as Ullmann-Ma reactions and have found extensive applications in organic synthesis.Qian Cai Wei Zhou 2020Chinese Journal of Chemistry2020,38,8:3
2Cu/Picolinamides-Catalyzed Coupling of (Hetero) aryl Halides with Secondary Phosphine Oxides and Phosphite显示文摘Some 4-hydroxy-picolinic acid derived amides were revealed as more efficient ligands for Cu-catalyzed coupling of(hetero)aryl halides with secondary phosphine oxides and phosphites.Only 3—5 mol%CuI and ligands were required to ensure coupling with a number of(hetero)aryl bromides and iodides to complete at 120 ℃ in 10—20 h.Chao Fang Bangguo Wei Dawei Ma 2021Chinese Journal of Chemistry2021,39,11:0
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