共被期刊论文引用了2次
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| 1 | A cell-permeable green fluorescent probe for dsDNA显示文摘The sensitive and selective detection of nucleic acids is important for basic research and many applied fields. Herein, a novel green DEAB-TO-1 was designed and synthesized. DEAB-TO-1 shows significant fluorescence enhancement(800-fold) when bound to ctDNA and a distinct selectivity for dsDNA over RNA(5.9 times). Moreover, the limit of detection is 0.57 ng/ml. It is live-cell-permeant DNA intecalator,indicating a promising candidate for nucleus-specific imaging and a good counter-stain compatibility with other dyes. | Dandan Ma Tao Liu Qichao Yao Xiaojun Peng | 2018 | Science China Chemistry2018，61，4： | 1 |
| 2 | Real-time observation of dynamic heterogeneity of gold nanorods on plasma membrane with darkfield microscopy显示文摘The plasma membrane possesses a complicated structure, on which the protein clusters are randomly but orderly distributed to maintain the regular morphology and function of cells. Investigating the detailed dynamic behaviors of nanoparticles(NPs) on cytomembrane is of great importance to understand cellular mechanisms and advance the bio-nano technologies for drug delivery, photothermal therapy, immunotherapy, etc. In this work, to study the dynamic heterogeneous interactions between NPs and cell membrane with high resolution, we established a simple method to efficiently track the translational and rotational diffusion of individual gold nanorods(AuNRs) on cell membranes. This method is based on that an anisotropic AuNR appears as a colored spot under a darkfield microscope(DFM) equipped with a color camera. While obtaining its lateral position, the polar angle of the AuNR can be calculated simultaneously from intensity difference between the R and G channels. Careful analysis shows that the lateral motion of single AuNRs do not follow normal Brownian diffusion, which could be attributed to their hop diffusion in the dynamically varying picket-fence structure of the live cell membrane. Furthermore, 4 different rotationtranslation patterns of the AuNR are observed due to spatiotemporal heterogeneity of the cytomembrane. This simple but robust method for simultaneously obtaining the location and orientation of anisotropic plasmonic nanoparticles could be further applied to the analysis of complicated biological and biomedical processes. | Feng Ge Jianfeng Xue Zonghua Wang Bin Xiong Yan He | 2019 | Science China Chemistry2019，62，8： | 1 |
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