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| 1 | 维持性血液透析患者全血微量元素与慢性肾脏病相关性瘙痒症程度的关联分析显示文摘目的探讨维持性血液透析(maintenance hemodialysis,MHD)患者全血微量元素和慢性肾脏病相关性瘙痒症(chronic kidney disease-associated pruritus,CKD-aP)程度的关系。方法采用单中心横断面研究方法,纳入2019年9月在暨南大学附属广州红十字会医院血液净化中心长期规律治疗的患者为研究对象,记录患者人口学资料、实验室指标和临床数据,测定透析前锰、锌、铜、硒、铅等微量元素全血含量水平。采用Dirk R Kuypers评分法评估MHD患者皮肤瘙痒情况,依据评分结果将患者分为无瘙痒组、轻度瘙痒组、中度瘙痒组和重度瘙痒组,并分析各组患者临床特征,最后通过有序Logistic回归分析影响MHD患者CKD-aP程度的相关因素。结果共纳入121例患者,其中无瘙痒组45例,轻度瘙痒组59例、中度瘙痒组12例、重度瘙痒组5例;轻度瘙痒组和重度瘙痒组的男性比例高于女性比例,中度瘙痒组中的女性比例高于男性(P<0.05);瘙痒程度越高,组中患者的C反应蛋白水平越高(P<0.05);尽管各全血微量元素水平在不同瘙痒程度各组中差异无统计学意义,但在单变量分析中,全血锰和较高的瘙痒程度相关,其他的微量元素均与瘙痒程度无关。校正了混杂因素后,多变量有序多分类Logistic回归分析结果显示MHD患者较低的全血锰与较高的皮肤瘙痒程度独立相关(P<0.05)。结论较低的全血锰可能在MHD患者CKD-aP中起了重要作用。 | 鲍敏锐 刘云 许世林 谭荣韶 邹得娥 梁威锋 黎淑婷 陈文璇 刘岩 钟小仕 | 2021 | 临床肾脏病杂志2021，21，8： | 5 |
| 2 | Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway显示文摘Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2(UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD rats.These results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress. | Jian Guan Miao Zhao Chao He Xue Li Ying Li Jie Sun Wei Wang Ya-Li Cui Qing Zhang Bai-Yan Li Guo-Fen Qiao | 2019 | Neuroscience Bulletin2019，35，1： | 5 |
| 3 | Chronic Intracerebroventricular Infusion of Metformin Inhibits Salt-Sensitive Hypertension via Attenuation of Oxidative Stress and Neurohormonal Excitation in Rat Paraventricular Nucleus显示文摘Metformin(MET), an antidiabetic agent, also has antioxidative effects in metabolic-related hypertension.This study was designed to determine whether MET has anti-hypertensive effects in salt-sensitive hypertensive rats by inhibiting oxidative stress in the hypothalamic paraventricular nucleus(PVN). Salt-sensitive rats received a highsalt(HS) diet to induce hypertension, or a normal-salt(NS)diet as control. At the same time, they received intracerebroventricular(ICV) infusion of MET or vehicle for 6 weeks. We found that HS rats had higher oxidative stress levels and mean arterial pressure(MAP) than NS rats. ICV infusion of MET attenuated MAP and reduced plasma norepinephrine levels in HS rats. It also decreased reactive oxygen species and the expression of subunits of NAD(P)H oxidase, improved the superoxide dismutase activity,reduced components of the renin-angiotensin system, and altered neurotransmitters in the PVN. Our findings suggest that central MET administration lowers MAP in saltsensitive hypertension via attenuating oxidative stress,inhibiting the renin-angiotensin system, and restoring the balance between excitatory and inhibitory neurotransmitters in the PVN. | Xiao-Jing Yu Ya-Nan Zhao Yi-Kang Hou Hong-Bao Li Wen-Jie Xia Hong-Li Gao Kai-Li Liu Qing Su Hui-Yu Yang Bin Liang Wen-Sheng Chen Wei Cui Ying Li Guo-Qing Zhu Zhi-Ming Yang Yu-Ming Kang | 2019 | Neuroscience Bulletin2019，35，1： | 5 |
| 4 | Recent Progress in Understanding the Mechanisms of Pain and Itch:the Second Special Issue显示文摘In 2012,we published the first special issue on mechanisms of pain and itch in Neuroscience Bulletin,which covered the peripheral,central,and glial mechanisms of pain and itch[1-5].In the last 5 years,the field has seen tremendous progress in the molecular and functional characterization of primary sensory neurons[6,7],neurocircuits of pain and itch[8-10],immune and glial modulation of pain and | Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 5 |
| 5 | 推广和实施慢性病自我管理健康教育的应用前景显示文摘随着我国现代化社会经济的飞速发展,社会环境与空气质量、经济及生活压力等日益加剧,慢性非传染性疾病(以下简称慢性病)患病率逐渐提高。慢性病发病时间长便会对患者的身心健康造成很大影响,严重降低患者生活质量。随着我国医疗事业的飞速发展,人们更加注重自身健康问题,健康教育已成为临床护理工作中必不可少的内容,而期间提高患者自我管理能力尤为关键。 | 魏晓龙 | 2018 | 慢性病学杂志2018，18，10： | 3 |
| 6 | 当归苦参丸止痒功效的初步机制探究显示文摘目的:探究当归苦参丸改善急性、慢性瘙痒的药效作用,为当归苦参丸的止痒作用及临床用药提供科学依据。方法:采用4-氨基吡啶(4-aminopyridine,4-AP)、右旋糖酐-40(dextran-40)致昆明种小鼠急性瘙痒模型,观察不同剂量当归苦参丸的止痒作用;采用Compound 48/80(C48/80)致小鼠皮肤瘙痒模型,观察不同剂量当归苦参丸对肥大细胞脱颗粒诱发的小鼠瘙痒的干预作用;采用二甲苯致小鼠急性炎症模型,观察不同剂量当归苦参丸的抗炎作用;采用MC903建立特应性皮炎慢性瘙痒模型,观察不同剂量当归苦参丸的抗慢性瘙痒作用。结果:当归苦参丸可改善4-AP和右旋糖酐-40致小鼠急性瘙痒,抑制4-AP小鼠血清中组胺(histamine,HIS)、白三烯B4(leukotriene B4,LTB4)表达;可改善C48/80诱发的瘙痒,抑制肥大细胞脱颗粒和HIS、类胰蛋白酶的表达;可降低二甲苯刺激的小鼠耳肿胀度及提高耳肿胀度抑制率;可改善MC903诱发的特应性皮炎慢性瘙痒,抑制血清中IgE、HIS、TSLP、IL-4、IL-13、IL-33和耳片匀浆中HIS、TSLP、IL-4、IL-13、IL-33的表达水平。结论:当归苦参丸可改善急性、慢性瘙痒,有助于科学性地指导临床用药,提高患者的接受度。 | 谭伟 刘燕娇 邓世俊 王睿睿 饶高雄 张丽娟 张祎 | 2023 | 中国医院药学杂志2023，43，16： | 0 |
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