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| 1 | Multi-epitope vaccines: a promising strategy against tumors and viral infections显示文摘Immune responses play a critical role in fighting tumors and viral infections.An antigenic epitope is a basic unit that elicits either a cellular or a humoral immune response.A multi-epitope vaccine composed of a series of or overlapping peptides is therefore an ideal approach for the prevention and treatment of tumors or viral infections.1,2,3,4,5 Although some multi-epitope vaccines have entered phase I clinical trials,for example,EMD640744 in patients with advanced solid tumors,6 designing efficacious multi-epitope vaccines remains a great challenge.An ideal multi-epitope vaccine should be designed to include epitopes that can elicit CTL,Th and B cells and induce effective responses against a targeted tumor or virus(Figure 1). | Lifang Zhang | 2018 | Cellular & Molecular Immunology2018，15，2： | 8 |
| 2 | 基于流感病毒血凝素茎部结构域的通用疫苗研究进展显示文摘流感病毒因其变异快、传播速度快、感染性和致病性强等特点严重威胁着人类健康,通用流感疫苗的制备迫在眉睫,流感病毒血凝素茎部结构域因其保守性和诱导广泛保护性免疫的潜能,成为通用疫苗的研究重点,本文就流感病毒血凝素茎部通用疫苗的最新研究进展进行综述。 | 杨新燕 沃恩康 张儒轩 方迪 刘亚辉 郭潮潭 | 2018 | 医学研究杂志2018，47，3： | 2 |
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